Association Between Hepatic Steatosis and Deterioration of Metabolic Health in Obese Individuals: A 12-Year Follow-Up of the Tehran Lipid and Glucose Study [0.03%]
Tehran Lipid and Glucose研究中肥胖者肝脂肪变性与代谢健康恶化的关联：12年随访结果
Behnaz Abiri,Mohammad Nikoohemmat,Maryam Mahdavi et al.
Behnaz Abiri et al.
Background: Uncertainty surrounds the relationship between metabolic decline and fatty liver disease. The purpose of this study was to evaluate the effect of hepatic steatosis (HS) on the transition from metabolically hea...
Associations of Multimarkers of Metabolic Malnutrition and Inflammation With All-Cause Mortality and Their Interplay With Thyroid Function [0.03%]
代谢性营养不良和炎症多重标志物与全因死亡率的关联及其与甲状腺功能的相互作用
Setor K Kunutsor,Reyhaneh Rikhtehgaran,Yanning Xu et al.
Setor K Kunutsor et al.
Introduction: The metabolic vulnerability index (MVX)-a composite biomarker reflecting metabolic malnutrition and inflammation-has been linked to increased mortality risk in populations with cardiovascular disease. Thyroi...
Hepato-Renal Protective Potential of Dimethyl Fumarate in Alloxan-Induced Diabetic Mice Model by Modulating of Sirt1, Nrf2 and Inflammatory Genes Expressions [0.03%]
二甲基富马酸通过调节Sirt1，Nrf2和炎症基因表达对alloxan诱导的糖尿病小鼠肝肾保护潜力的研究
Parisa Saberi-Hasanabadi,Fatemeh Shaki,Mohammad Karami et al.
Parisa Saberi-Hasanabadi et al.
Aim: Despite advances in diabetes treatments, the effects of this disease have not yet been adequately reversed or prevented in patients. Therefore, development of more effective medication-assisted treatments in this fie...
Effects of Cardamom on Neuroinflammation, Learning and Memory in Mice Fed a Cafeteria Diet [0.03%]
肉豆蔻对西式膳食模式喂养小鼠神经炎症和学习记忆能力的影响
Anfal Al-Dalaeen,Nour Batarseh,Sally Atawneh
Anfal Al-Dalaeen
Background: The consumption of a cafeteria diet is described as deleterious to cognitive performance, potentially due to inducing inflammation in the brain. Cardamom, a potent antioxidant, may benefit brain health. In the...
Targeting the NEK7/NLRP3 Inflammasome Axis: Synergistic Protection of Intravitreal MCC950 and Systemic Metformin Against Diabetic Retinopathy in Rats [0.03%]
靶向NEK7/NLRP3炎性小体轴：MCC950和口服二甲双胍联合玻璃体内注射对糖尿病大鼠视网膜病变的协同保护作用
Kexuan Ren,Xiaofeng Li
Kexuan Ren
Objective: Diabetic retinopathy (DR) is characterised by chronic neuroinflammation where the NLRP3 inflammasome plays a pivotal role. This study investigated the therapeutic potential and underlying mechanism of combining...
A Nationwide Danish Comparative Effectiveness Study of GLP-1 RA, SGLT2i and DPP-4i Treatment on Risk of Stroke, Myocardial Infarction and Mortality in Type 2 Diabetes [0.03%]
丹麦全国范围内针对2型糖尿病患者使用GLP-1受体激动剂、SGLT2抑制剂和DPP-4抑制剂治疗的有效性比较研究：对卒中、心肌梗死和死亡风险的影响
Sidsel Hastrup,Jakob N Hedegaard,Grethe Andersen et al.
Sidsel Hastrup et al.
Aims: Cardiovascular outcome trials have demonstrated that glucagon-like peptide-1 receptor agonists (GLP-1 RA) and sodium-glucose cotransporter 2 inhibitors (SGLT2i) reduce the risk of major adverse cardiovascular events...
Comparative Study
Endocrinology, diabetes & metabolism. 2026 Jan;9(1):e70165. DOI:10.1002/edm2.70165 2026
Association Between the Triglycerides-to-High-Density Lipoprotein-Cholesterol (TG/HDL-C) Ratio and Chronic Kidney Disease: A Systematic Review and Meta-Analysis of Observational Studies [0.03%]
甘油三酯与高密度脂蛋白胆固醇比值与慢性肾脏病相关性的系统评价和meta分析
Mansour Bahardoust,Sheida Shokohyar,Ali Delpisheh et al.
Mansour Bahardoust et al.
Background: The relationship between the triglycerides-to-high-density lipoprotein cholesterol (TG/HDL-C) ratio and the risk of developing chronic kidney disease (CKD) remains unclear, as CKD is a major health challenge w...
Socioeconomic Inequalities and Type 2 Diabetes Comorbidities: A Systematic Review and Meta-Analysis on Observational Studies [0.03%]
基于观察性研究的系统回顾和荟萃分析：社会经济差距与2型糖尿病伴发疾病的关系
Mansour Bahardoust,Sheida Shokohyar,Farzad Maleki et al.
Mansour Bahardoust et al.
Background: Previous studies have reported inconsistent findings regarding the relationship between socioeconomic status (SES) inequalities and comorbidities in patients with diabetes mellitus (DM). This systematic review...
Tirzepatide and Cardiovascular Outcomes: A Narrative Review of Mechanisms, Efficacy and Implications for Heart Failure Management [0.03%]
tirzepatide与心血管结局：机制、疗效及对心力衰竭管理的意义的叙述性回顾
Hamza A Abdul-Hafez,Ameer Awashra,Sosana Bdir et al.
Hamza A Abdul-Hafez et al.
Background: Tirzepatide, a dual GIP/GLP-1 receptor agonist, offers a novel cardiometabolic strategy beyond glycemic control with important implications for heart failure care. By producing potent, sustained weight reducti...