Defense Advanced Research Projects Agency: Comment on 'Engineering biology and the grand challenges: Do we need a new R&D&I model?' [0.03%]
评论：“工程生物学与重大挑战——我们需要新的研究、开发和创新模式吗？” DARPA 的回应
Ilya Klabukov,Olga Krasilnikova
Ilya Klabukov
This comment paper refers to the article published by Gauvreau et al. in Engineering Biology in 2018. Gauvreau et al. discussed various civilian models in the private and public sectors that could boost R&D plus Innovation (R&D&I) progress ...
Reducing metabolic burden in the PACEmid evolver system by remastering high-copy phagemid vectors [0.03%]
通过重塑高拷贝噬菌体辅助质粒载体减轻PACEmid进化系统中的代谢负担
Beth India Davenport,Jure Tica,Mark Isalan
Beth India Davenport
Orthogonal or non-cross-reacting transcription factors are used in synthetic biology as components of genetic circuits. Brödel et al. (2016) engineered 12 such cIλ transcription factor variants using a directed evolution 'PACEmid' system....
Agata Kennedy,Guy Griffin,Paul S Freemont et al.
Agata Kennedy et al.
In synthetic biology, biosensors are routinely coupled with a gene expression system for detecting small molecules and physical signals. We reveal a fluorescent complex, based on the interaction of an Escherichia coli double bond reductase ...
Engineering of optogenetic devices for biomedical applications in mammalian synthetic biology [0.03%]
用于生物医药应用的哺乳动物合成生物学光遗传器件工程化研究进展
Ningzi Guan,Xianyun Gao,Haifeng Ye
Ningzi Guan
Gene- and cell-based therapies are the next frontiers in the field of medicine. Both are transformative and innovative therapies; however, a lack of safety data limits the translation of such promising technologies to the clinic. Improving ...
Angelo C Batista,Paul Soudier,Manish Kushwaha et al.
Angelo C Batista et al.
Over the last decades, cell-free systems have been extensively used for in vitro protein expression. A vast range of protocols and cellular sources varying from prokaryotes and eukaryotes are now available for cell-free technology. However,...
Richard I Kitney,Chueh Loo Poh
Richard I Kitney
Responsible innovation: Its role in an era of technological and regulatory transformation [0.03%]
负责任的创新：技术与监管变革时代的作用
Joyce Tait,Alex Brown,Isabela Cabrera Lalinde et al.
Joyce Tait et al.
In the development of innovative technology products, companies of all sizes are being encouraged to innovate responsibly and regulators are encouraged to adapt their regulatory systems to be smarter, more proportionate and adaptive to the ...
Biologically engineered microbes for bioremediation of electronic waste: Wayposts, challenges and future directions [0.03%]
生物工程微生物修复电子废弃物：路标、挑战和未来方向
Ping Han,Wei Zhe Teo,Wen Shan Yew
Ping Han
In the face of a burgeoning stream of e-waste globally, e-waste recycling becomes increasingly imperative, not only to mitigate the environmental and health risks it poses but also as an urban mining strategy for resource recovery of precio...
The influences of substrates' physical properties on enzymatic PET hydrolysis: Implications for PET hydrolase engineering [0.03%]
基质物理性质对PET酶降解影响的研究及PET酶的改造意义
Rupali Reddy Pasula,Sierin Lim,Farid J Ghadessy et al.
Rupali Reddy Pasula et al.
Plastic pollution in diverse terrestrial and marine environments is a widely recognised and growing problem. Bio-recycling and upcycling of plastic waste is a potential solution to plastic pollution, as these processes convert plastic waste...
Sierin Lim,Travis Bayer
Sierin Lim