Effect of apolipoprotein E polymorphism on cognition and brain in the Cambridge Centre for Ageing and Neuroscience cohort [0.03%]
载脂蛋白E基因多态性对剑桥老年学中心认知和脑的影响
Richard N Henson,Sana Suri,Ethan Knights et al.
Richard N Henson et al.
Polymorphisms in the apolipoprotein E (APOE) gene have been associated with individual differences in cognition, brain structure and brain function. For example, the ε4 allele has been associated with cognitive and brain impairment in old ...
(2 S,6 S)- and (2 R,6 R)-hydroxynorketamine inhibit the induction of NMDA receptor-dependent LTP at hippocampal CA1 synapses in mice [0.03%]
(2 S,6 S)-和(2 R,6 R)-水合羟基诺 ketamine 抑制小鼠海马 CA1 突触中NMDA 体依赖的LTP诱导
Heather Kang,Pojeong Park,Muchun Han et al.
Heather Kang et al.
The ketamine metabolite (2R,6R)-hydroxynorketamine has been proposed to have rapid and persistent antidepressant actions in rodents, but its mechanism of action is controversial. We have compared the ability of (R,S)-ketamine with the (2S,6...
Medial entorhinal cortex lesions induce degradation of CA1 place cell firing stability when self-motion information is used [0.03%]
内侧海马回病变导致CA1房间细胞发射稳定性的下降当使用自我运动信息时
Pierre-Yves Jacob,Tiffany Van Cauter,Bruno Poucet et al.
Pierre-Yves Jacob et al.
The entorhinal-hippocampus network plays a central role in navigation and episodic memory formation. To investigate these interactions, we examined the effect of medial entorhinal cortex lesions on hippocampal place cell activity. Since the...
Nichola M Brydges,Jack Reddaway
Nichola M Brydges
Exposure to adverse experiences during development increases the risk of psychiatric illness later in life. Growing evidence suggests a role for the neuroimmune system in this relationship. There is now substantial evidence that the immune ...
Organisation of cingulum bundle fibres connecting the anterior thalamic nuclei with the rodent anterior cingulate and retrosplenial cortices [0.03%]
连接前丘脑核与啮齿动物前扣带和后伞状皮层的cingulum束纤维的组织结构
Emma J Bubb,Andrew J D Nelson,Thomas C Cozens et al.
Emma J Bubb et al.
Despite considerable interest in the properties of the cingulum bundle, descriptions of the composition of this major pathway in the rodent brain have not kept pace with advances in tract tracing. Using complementary approaches in rats and ...
Impaired episodic simulation in a patient with visual memory deficit amnesia [0.03%]
视觉记忆缺陷遗忘症患者的情节模拟受损
Alexander Easton,Jamie P Cockcroft,Kamar E Ameen-Ali et al.
Alexander Easton et al.
For the first time, we assess episodic simulation in a patient with visual memory deficit amnesia, following damage to visual association cortices. Compared to control participants, the patient with visual memory deficit amnesia shows sever...
Mild inflammation causes a reduction in resting-state amplitude of low-frequency fluctuation in healthy adult males [0.03%]
轻微炎症导致健康成年男性静息态低频波动幅度降低
Kristian Stefanov,John McLean,Becky Allan et al.
Kristian Stefanov et al.
Systemic inflammation has been associated with negative mood states and human sickness behaviour. Previous studies have shown an association between systemic inflammation and changes in task-related blood-oxygen-level-dependent activity and...
Alejandra Alonso,Jacqueline van der Meij,Dorothy Tse et al.
Alejandra Alonso et al.
In humans, most of our new memories are in some way or another related to what we have already experienced. However, in memory research, especially in non-human animal research, subjects are often mostly naïve to the world. But we know tha...
Ventral midline thalamus is not necessary for systemic consolidation of a social memory in the rat [0.03%]
腹侧正中丘脑对于大鼠社会记忆的整体巩固不是必需的
Etienne Quet,Jean-Christophe Cassel,Brigitte Cosquer et al.
Etienne Quet et al.
According to the standard theory of memory consolidation, recent memories are stored in the hippocampus before their transfer to cortical modules, a process called systemic consolidation. The ventral midline thalamus (reuniens and rhomboid ...
Lateral entorhinal cortex lesions impair both egocentric and allocentric object-place associations [0.03%]
侧扣带前回损伤损害无论是自我中心还是他者中心的对象地点联系能力
Maneesh V Kuruvilla,David I G Wilson,James A Ainge
Maneesh V Kuruvilla
During navigation, landmark processing is critical either for generating an allocentric-based cognitive map or in facilitating egocentric-based strategies. Increasing evidence from manipulation and single-unit recording studies has highligh...