Maternal obesity and developmental programming of neuropsychiatric disorders: An inflammatory hypothesis [0.03%]
母体肥胖和神经精神疾病的发展编程：一种炎症假说
Jonathan Davis,Erik Mire
Jonathan Davis
Maternal obesity is associated with the development of a variety of neuropsychiatric disorders; however, the mechanisms behind this association are not fully understood. Comparison between maternal immune activation and maternal obesity rev...
Early-life stress and inflammation: A systematic review of a key experimental approach in rodents [0.03%]
早期生活压力与炎症：啮齿类动物关键实验方法的系统性回顾
Ethan G Dutcher,E A Claudia Pama,Mary-Ellen Lynall et al.
Ethan G Dutcher et al.
Repeated maternal separation is the most widely used pre-clinical approach to investigate the relationship between early-life chronic stress and its neuropsychiatric and physical consequences. In this systematic review, we identified 46 stu...
Striatal and hippocampal contributions to flexible navigation in rats and humans [0.03%]
纹状体和海马在大鼠和人类灵活导航中的作用
Christoffer J Gahnstrom,Hugo J Spiers
Christoffer J Gahnstrom
The hippocampus has been firmly established as playing a crucial role in flexible navigation. Recent evidence suggests that dorsal striatum may also play an important role in such goal-directed behaviour in both rodents and humans. Across r...
The role of cytokines in modulating learning and memory and brain plasticity [0.03%]
细胞因子在调节学习记忆和脑可塑性中的作用
Julie-Myrtille Bourgognon,Jonathan Cavanagh
Julie-Myrtille Bourgognon
Cytokines are proteins secreted in the central nervous system by neurons, microglia, astrocytes and infiltrating peripheral immune cells under physiological and pathological conditions. Over the last 20 years, a growing number of reports ha...
Neurophysiological coding of space and time in the hippocampus, entorhinal cortex, and retrosplenial cortex [0.03%]
海马体、内嗅皮质和后顶叶皮质中空间和时间的神经生理编码
Andrew S Alexander,Jennifer C Robinson,Holger Dannenberg et al.
Andrew S Alexander et al.
Neurophysiological recordings in behaving rodents demonstrate neuronal response properties that may code space and time for episodic memory and goal-directed behaviour. Here, we review recordings from hippocampus, entorhinal cortex, and ret...
Spontaneous object-location memory based on environmental geometry is impaired by both hippocampal and dorsolateral striatal lesions [0.03%]
海马和背外侧纹状体损伤均会损害基于环境几何形状的自发物体位置记忆
Steven L Poulter,Yutaka Kosaki,David J Sanderson et al.
Steven L Poulter et al.
We examined the role of the hippocampus and the dorsolateral striatum in the representation of environmental geometry using a spontaneous object recognition procedure. Rats were placed in a kite-shaped arena and allowed to explore two disti...
Gilda E Ennis,Ursula Saelzler,Guillermo E Umpierrez et al.
Gilda E Ennis et al.
Insulin sensitivity, pancreatic β-cell function, fasting glucose, and 2-h post-load glucose were related to cognition in cognitively healthy nondiabetic older adults. Thirty-five adults (⩾65 years) underwent a 2-h oral glucose tolerance t...
Effect of apolipoprotein E polymorphism on cognition and brain in the Cambridge Centre for Ageing and Neuroscience cohort [0.03%]
载脂蛋白E基因多态性对剑桥老年学中心认知和脑的影响
Richard N Henson,Sana Suri,Ethan Knights et al.
Richard N Henson et al.
Polymorphisms in the apolipoprotein E (APOE) gene have been associated with individual differences in cognition, brain structure and brain function. For example, the ε4 allele has been associated with cognitive and brain impairment in old ...
(2 S,6 S)- and (2 R,6 R)-hydroxynorketamine inhibit the induction of NMDA receptor-dependent LTP at hippocampal CA1 synapses in mice [0.03%]
(2 S,6 S)-和(2 R,6 R)-水合羟基诺 ketamine 抑制小鼠海马 CA1 突触中NMDA 体依赖的LTP诱导
Heather Kang,Pojeong Park,Muchun Han et al.
Heather Kang et al.
The ketamine metabolite (2R,6R)-hydroxynorketamine has been proposed to have rapid and persistent antidepressant actions in rodents, but its mechanism of action is controversial. We have compared the ability of (R,S)-ketamine with the (2S,6...
Medial entorhinal cortex lesions induce degradation of CA1 place cell firing stability when self-motion information is used [0.03%]
内侧海马回病变导致CA1房间细胞发射稳定性的下降当使用自我运动信息时
Pierre-Yves Jacob,Tiffany Van Cauter,Bruno Poucet et al.
Pierre-Yves Jacob et al.
The entorhinal-hippocampus network plays a central role in navigation and episodic memory formation. To investigate these interactions, we examined the effect of medial entorhinal cortex lesions on hippocampal place cell activity. Since the...