Dissociating the effects of distraction and proactive interference on object memory through tests of novelty preference [0.03%]
通过新颖性偏爱测试将注意力分散和前瞻式干扰对物体记忆的影响分开
K Landreth,U Simanaviciute,J Fletcher et al.
K Landreth et al.
Encoding information into memory is sensitive to distraction while retrieving that memory may be compromised by proactive interference from pre-existing memories. These two debilitating effects are common in neuropsychiatric conditions, but...
Reducing voltage-dependent potassium channel Kv3.4 levels ameliorates synapse loss in a mouse model of Alzheimer's disease [0.03%]
降低阿尔茨海默病小鼠模型中电压依赖性钾通道Kv3.4的水平可减轻突触丢失
Jie Yeap,Chaitra Sathyaprakash,Jamie Toombs et al.
Jie Yeap et al.
Synapse loss is associated with cognitive decline in Alzheimer's disease, and owing to their plastic nature, synapses are an ideal target for therapeutic intervention. Oligomeric amyloid beta around amyloid plaques is known to contribute to...
Modelling falls in Parkinson's disease and normal ageing in mice using a complex motor task [0.03%]
利用复杂运动任务在小鼠中建立帕金森病和正常衰老中的跌倒模型
Megan G Jackson,Laura J Brennan,Emily J Henderson et al.
Megan G Jackson et al.
Falls resulting from multifactorial deficits are common in both normal ageing and Parkinson's disease. Resultant injuries can lead to increased hospitalisation and excess mortality. As the disease progresses, gait and balance deficits are r...
A systematic review of studies investigating the acute effects of N-methyl- D-aspartate receptor antagonists on behavioural despair in normal animals suggests poor predictive validity [0.03%]
一项系统性综述：N-甲基-D天冬氨酸受体拮抗剂急性作用于正常动物的行为绝望反应预测价值较低
Martin Viktorov,Matthew P Wilkinson,Victoria C E Elston et al.
Martin Viktorov et al.
The ability of the N-methyl-D-aspartate receptor antagonist ketamine to induce a rapid and sustained antidepressant effect has led to a surge in pre-clinical studies investigating underlying mechanisms and seeking novel treatments. Animal m...
Climate crisis and ecological emergency: Why they concern (neuro)scientists, and what we can do [0.03%]
气候危机与生态紧急状况：它们为何关乎（神经）科学家，我们能做些什么
Charlotte L Rae,Martin Farley,Kate J Jeffery et al.
Charlotte L Rae et al.
Our planet is experiencing severe and accelerating climate and ecological breakdown caused by human activity. As professional scientists, we are better placed than most to understand the data that evidence this fact. However, like most othe...
Emotion-driven problem behaviour: The predictive utility of positive and negative urgency [0.03%]
受情绪驱动的问题行为：积极冲动和消极冲动的预测效用
Christopher Willie,Peter Richard Gill,Robert Teese et al.
Christopher Willie et al.
Impulsive urgency describes the tendency to act rashly when experiencing extreme emotions. This Australian study aimed to investigate the predictive utility of impulsivity, including impulsive urgency (positive and negative), across a range...
Emotion-related impulsivity: Testing a model of arousal effects on cognitive control [0.03%]
情绪冲动性：测试警觉对认知控制的影响的模型
Jennifer G Pearlstein,Sheri L Johnson,James W Madole et al.
Jennifer G Pearlstein et al.
The trait-based tendency to respond rashly to emotions is robustly tied to many forms of psychopathology and poor behavioural outcomes, including aggression and suicidality. Researchers have found associations between response inhibition an...
No evidence for trait- and state-level urgency moderating the daily association between negative affect and subsequent alcohol use in two college samples [0.03%]
两项大学样本中负面情绪与随后饮酒之间日常关联的特质型和状态型冲动性调节作用的证据不足
Jonas Dora,Megan E Schultz,Yuichi Shoda et al.
Jonas Dora et al.
It remains unclear whether the negative reinforcement pathway to problematic drinking exists, and if so, for whom. One idea that has received some support recently is that people who tend to act impulsively in response to negative emotions ...
Factors in the neurodevelopment of negative urgency: Findings from a community-dwelling sample [0.03%]
来自社区留居样本的神经发育中负面紧迫感的因素发现
Casey L Evans,Kayle S Sawyer,Sarah A Levy et al.
Casey L Evans et al.
This study investigated neuroanatomic, genetic, cognitive, sociodemographic and emotional underpinnings of the Negative Urgency subscale of the Urgency, Premeditation, Perseverance, Sensation-Seeking and Positive Urgency Impulsive Behavior ...
Individual differences in theta-band oscillations in a spatial memory network revealed by electroencephalography predict rapid place learning [0.03%]
空间记忆网络中个体差异的θ频段脑电振荡预测快速空间学习
Markus Bauer,Matthew G Buckley,Tobias Bast
Markus Bauer
Spatial memory has been closely related to the medial temporal lobe and theta oscillations are thought to play a key role. However, it remains difficult to investigate medial temporal lobe activation related to spatial memory with non-invas...