Apolipoprotein E isoform does not influence trans-synaptic spread of tau pathology in a mouse model [0.03%]
载脂蛋白E亚型不影响tau病理异质性扩散（小鼠模型）
Caitlin Davies,Jane Tulloch,Ellie Yip et al.
Caitlin Davies et al.
A key hallmark of Alzheimer's disease (AD) is the accumulation of hyperphosphorylated tau in neurofibrillary tangles. This occurs alongside neuroinflammation and neurodegeneration. Pathological tau propagates through the AD brain in a defin...
Teriflunomide treatment outcomes in multiple sclerosis: A Portuguese real-life experience [0.03%]
特立氟胺治疗多发性硬化患者的疗效：葡萄牙的真实世界经验
Carla Cecília Nunes,Pedro Abreu,Filipe Correia et al.
Carla Cecília Nunes et al.
Teriflunomide is an oral disease-modifying therapy for relapsing-remitting multiple sclerosis patients. A decline in physical and cognitive functions, which negatively impacts their quality of life (QoL), is observed in relapsing-remitting ...
Identifying applications of virtual reality to benefit the stroke translational pipeline [0.03%]
识别虚拟现实的优势以造福卒中转化链式反应
Matan Bone,Maham Malik,Siobhan Crilly
Matan Bone
As a leading cause of mortality and morbidity, stroke and its management have been studied extensively. Despite numerous pre-clinical studies identifying therapeutic targets, development of effective, specific pharmacotherapeutics remain li...
Kate Baker
Kate Baker
Septotemporal variation in modulation of synaptic transmission, paired-pulse ratio and frequency facilitation/depression by adenosine and GABAB receptors in the rat hippocampus [0.03%]
腺苷和GABAB受体在大鼠海马中的时相特异性调节突触传递的配对脉冲比率和频率强化/抑制作用
Maria A Samara,George D Oikonomou,George Trompoukis et al.
Maria A Samara et al.
Short-term synaptic plasticity represents a fundamental mechanism in neural information processing and is regulated by neuromodulators. Here, using field recordings from the CA1 region of adult rat hippocampal slices, we show that excitator...
Dissociating reward sensitivity and negative urgency effects on impulsivity in the five-choice serial reaction time task [0.03%]
奖赏敏感性和负性冲动效应在五选连续反应时任务中对冲动行为的分离研究
Chiara Toschi,Mona El-Sayed Hervig,Thiago Burghi et al.
Chiara Toschi et al.
Negative urgency describes the tendency for rash and impulsive behaviour during negative emotional states and has been linked to a number of psychiatric disorders. However, there has been limited research on negative urgency as an explanato...
Regulation of glutamate transport and neuroinflammation in a term newborn rat model of hypoxic-ischaemic brain injury [0.03%]
新生鼠缺氧缺血性脑损伤时谷氨酸转运及神经炎症的调节机制研究
Silvia Pregnolato,Hemmen Sabir,Karen Luyt et al.
Silvia Pregnolato et al.
In the newborn brain, moderate-severe hypoxia-ischaemia induces glutamate excitotoxicity and inflammation, possibly via dysregulation of candidate astrocytic glutamate transporter (Glt1) and pro-inflammatory cytokines (e.g. Tnfα, Il1β, Il...
Dissociating the effects of distraction and proactive interference on object memory through tests of novelty preference [0.03%]
通过新颖性偏爱测试将注意力分散和前瞻式干扰对物体记忆的影响分开
K Landreth,U Simanaviciute,J Fletcher et al.
K Landreth et al.
Encoding information into memory is sensitive to distraction while retrieving that memory may be compromised by proactive interference from pre-existing memories. These two debilitating effects are common in neuropsychiatric conditions, but...
Reducing voltage-dependent potassium channel Kv3.4 levels ameliorates synapse loss in a mouse model of Alzheimer's disease [0.03%]
降低阿尔茨海默病小鼠模型中电压依赖性钾通道Kv3.4的水平可减轻突触丢失
Jie Yeap,Chaitra Sathyaprakash,Jamie Toombs et al.
Jie Yeap et al.
Synapse loss is associated with cognitive decline in Alzheimer's disease, and owing to their plastic nature, synapses are an ideal target for therapeutic intervention. Oligomeric amyloid beta around amyloid plaques is known to contribute to...
Modelling falls in Parkinson's disease and normal ageing in mice using a complex motor task [0.03%]
利用复杂运动任务在小鼠中建立帕金森病和正常衰老中的跌倒模型
Megan G Jackson,Laura J Brennan,Emily J Henderson et al.
Megan G Jackson et al.
Falls resulting from multifactorial deficits are common in both normal ageing and Parkinson's disease. Resultant injuries can lead to increased hospitalisation and excess mortality. As the disease progresses, gait and balance deficits are r...