Genetically modified animals as models of neurodevelopmental conditions: A review of systematic review reporting quality [0.03%]
基因修饰动物作为神经发育状况模型的系统评价报告质量综述
Emma Wilson,Gillian Currie,Malcolm Macleod et al.
Emma Wilson et al.
Using genetically modified animals to model neurodevelopmental conditions helps better our understanding of biology underlying these conditions. Animal research has unique characteristics not shared with clinical research, meaning systemati...
Reflecting on 50 years of long-term potentiation: Insights from the Royal Society's LTP50 conference [0.03%]
第50届皇家学会LTP大会上的长期增强作用研讨会心得
Rufus Mitchell-Heggs,Dorothy Tse
Rufus Mitchell-Heggs
On November 20-21 2023, the Royal Society in London hosted a landmark scientific meeting led by Professor Wickliffe C Abraham, Professor Timothy VP Bliss, Professor Graham L Collingridge, and Professor Richard GM Morris. The conference, com...
Not all plaques are created equal: Uncovering a unique molecular signature in Alzheimer's disease [0.03%]
痴呆症 plaque分子标志物研究取得进展
Kristjan Holt,Emily Payne,Tara L Spires-Jones
Kristjan Holt
Although neuritic plaques - comprised of aggregated fibrils of the misfolded protein, amyloid β (Aβ) - have formed a central focus of Alzheimer's disease (AD) research for decades, it is now well understood that plaque burden alone is a p...
Children aged 5-13 years show adult-like disgust avoidance, but not proto-nausea [0.03%]
5至13岁的儿童表现出类似成人的回避厌恶，但没有初步恶心反应
Sameer N B Alladin,Dani Berry,Evgeniya Anisimova et al.
Sameer N B Alladin et al.
Disgust is a vital emotion in the avoidance of illness. Human adults across cultures show disgust towards sources of potential contamination or pathogens, and elect to avoid their ingestion or even to look at them. Stomach rhythms appear to...
Brain mechanisms of temporal processing in impulsivity: Relevance to attention-deficit hyperactivity disorder [0.03%]
冲动性时间处理的脑机制：注意缺陷多动障碍的相关性
Eleanor White,Jeffrey W Dalley
Eleanor White
In this article, we critique the hypothesis that different varieties of impulsivity, including impulsiveness present in attention-deficit hyperactivity disorder, encompass an accelerated perception of time. This conceptualisation provides i...
Does theta synchronicity of sensory information enhance associative memory? Replicating the theta-induced memory effect [0.03%]
感觉信息的theta同步性是否能增强联想记忆？重复theta诱导的记忆效应实验
Fatih Serin,Danying Wang,Matthew H Davis et al.
Fatih Serin et al.
The binding of information from different sensory or neural sources is critical for associative memory. Previous research in animals suggested that the timing of theta oscillations in the hippocampus is critical for long-term potentiation, ...
A multimodal approach connecting cortical and behavioural responses to the visual continuity illusion [0.03%]
连接视皮层和行为对视觉连续性错觉的多模态方法
Matthew C D Bailey,Johann F du Hoffmann,Jeffrey W Dalley
Matthew C D Bailey
In their recently published study, Gil, Valente and Shemesh combined behaviour, functional magnetic resonance imaging, electroencephalography and causal interventions to establish and validate a cortical processing substrate underlying the ...
Unscheduled changes in pre-clinical stroke model housing contributes to variance in physiological and behavioural data outcomes: A post hoc analysis [0.03%]
关于卒中模型饲养的意外变化导致生理和行为数据结果差异的事后分析
Aisling McFall,Delyth Graham,Stuart A Nicklin et al.
Aisling McFall et al.
Ischaemic stroke presents a significant problem worldwide with no neuroprotective drugs available. Many of the failures in the search for neuroprotectants are attributed to failure to translate from pre-clinical models to humans, which has ...
Sex-dependence of synaptic depression induced by activation of metabotropic glutamate receptors in rat hippocampus [0.03%]
大鼠海马中代谢型谷氨酸受体激活诱导的突触抑制具有性别差异性
Liam T Ralph,John Georgiou,Graham L Collingridge et al.
Liam T Ralph et al.
The modulation of synaptic efficacy by group I metabotropic glutamate receptors is dysregulated in several neurodevelopmental and neurodegenerative disorders impacting cognitive function. The progression and severity of these and other diso...
Unveiling coding of prediction and sharpening of perceptual features through multivariate pattern analysis [0.03%]
基于多变量模式分析的预测编码和感知特征锐化的大脑表征研究
Sung-Mu Lee,Petar Raykov,Andrea Greve
Sung-Mu Lee
A recent study by Blank, Alink and Büchel, uses multivariate neuroimaging to investigate how the human brain processes the strength of face-related expectations and explores whether these expectations are represented in the same regions th...