Extended High-Dose Tofacitinib Induction Improves Clinical Response in Ulcerative Colitis: A Multicenter Cohort Study [0.03%]
溃疡性结肠炎诱导期托法替尼高剂量治疗提高临床缓解率：一项多中心队列研究
R Gilmore,T Pham,R G Fernandes et al.
R Gilmore et al.
Background and aims: Tofacitinib, an oral Janus Kinase (JAK) inhibitor, has demonstrated efficacy for ulcerative colitis (UC) in clinical trials, but the optimal dosing regimen remains unclear. This study aims to assess t...
Outcomes of Clostridium difficile Infection in Patients With Idiopathic Pulmonary Fibrosis: Analysis of the Nationwide Inpatient Sample, 2016-2020 [0.03%]
美国住院患者抽样分析（2016-2020）：难辨梭菌感染在特发性肺纤维化患者中的预后情况
Chun Ho Szeto,Gloria Erazo Montalvan,Chung Yin Tai et al.
Chun Ho Szeto et al.
Background: Idiopathic pulmonary fibrosis (IPF) is a progressive lung disease with poor prognosis. Patients with IPF are frequently exposed to risk factors for Clostridium difficile infection (CDI), such as advanced age, ...
Intestinal Ultrasound Adds Diagnostic Value and Safety to a Dietitian-Led Clinic for Disorders of Gut-Brain Interaction [0.03%]
肠道超声为胃肠脑相互作用障碍的临床营养师诊所增添了诊断价值和安全性
R M Mathias,S L Plush,L E Edwards et al.
R M Mathias et al.
Background: Disorders of gut-brain interaction (DGBI) affect approximately 40% of the global population. Multidisciplinary models incorporating dietetic management are increasingly used, yet objective assessment tools rem...
Gut Microbiota and Extraintestinal Cancers: Mechanistic Insights and Microbiome-Targeted Interventions [0.03%]
肠道微生物群与肠外癌症：机制见解和针对微生物组的干预措施
Rishi Chowdhary,Manjeet Kumar Goyal,Kirti Arora et al.
Rishi Chowdhary et al.
The gut microbiota is a dynamic community of bacteria, viruses, fungi, and archaea that plays a pivotal role in regulating host immunity, metabolism, and systemic homeostasis. Dysbiosis, characterized by an imbalance in the microbial compos...
Comparison of Changes in Biomarkers With Changes in Endoscopic Scores in Patients With Ulcerative Colitis: A Single-Center, Retrospective, Observational Study [0.03%]
溃疡性结肠炎患者生物标志物变化与内镜评分变化的比较：一项单中心回顾性观察研究
Yosuke Yamada,Natsuki Ishida,Tomohiro Takebe et al.
Yosuke Yamada et al.
Aim: Fecal occult blood concentration, fecal calprotectin (FC) level, serum C-reactive protein (CRP) level, and erythrocyte sedimentation rate (ESR) are valuable biomarkers for ulcerative colitis (UC). However, their clin...
Efficacy and Safety of Switching From Intravenous to Subcutaneous Vedolizumab in Japanese Patients With Ulcerative Colitis: A Study Focusing on Injection-Site Reactions [0.03%]
溃疡性结肠炎患者从静脉注射维多珠单抗转换为皮下给药的疗效和安全性：重点关注注射部位反应的研究
Makoto Furuya,Kiichiro Yoza,Takeshi Yonezawa et al.
Makoto Furuya et al.
Background/aims: The subcutaneous (SC) formulation of vedolizumab is available as an alternative to the intravenous (IV) formulation in patients with ulcerative colitis (UC). However, data from Asian patients are limited,...
Oral Microbiome and Constipation: A Causal Link Revealed by Mendelian Randomization [0.03%]
口腔微生物组和便秘：孟德尔随机化揭示的因果关系
Ziyi Zhao,Jinlian Ling,Jiashu Chen
Ziyi Zhao
Background: Constipation affects approximately 15.3% of the global population. While the gut microbiome's role in constipation has been studied, the causal relationship between the oral microbiome and constipation remains...
Gastric Microbiome Alterations in Sepsis-Related Gastrointestinal Bleeding: Two Case Reports and Literature Review [0.03%]
脓毒症相关消化道出血患者胃微生物群的改变：2例报告及文献复习
Fangjie Fu,Chen Zhang,Zhengying Xu et al.
Fangjie Fu et al.
Sepsis, characterized by life-threatening organ dysfunction resulting from an uncontrolled response to infection, can impact various systems of the body, including the digestive system. Prior research has identified sepsis as a significant ...
Loss of Response to Anti-Tumor Necrosis Factor Alpha Therapy in Patients With Inflammatory Bowel Disease: A Real-World Comparison of Combination Therapy Versus Monotherapy [0.03%]
炎症性肠病患者抗肿瘤坏死因子α治疗无应答的现状研究：联合疗法与单药疗法的比较
Faris Chater,Maja Kopczynska,Mahdi Saeidinejad et al.
Faris Chater et al.
Objectives: The success of anti-TNFα agents has changed the landscape of treatment for inflammatory bowel diseases (IBD). One major limitation to this success is the secondary loss of response (sLOR) phenomenon. Combinat...
Artificial Intelligence-Driven Colonoscopy: A Systematic Review and Network Meta-Analysis on System Performance for Colorectal Neoplasia Detection [0.03%]
基于人工智能的结肠镜检查：结直肠肿瘤检测系统性能的系统评价和网状meta分析
F N U Eman,F N U Gyaneshwari,Raveena Kumari et al.
F N U Eman et al.
Background: Colorectal cancer (CRC) is a major global health issue, with adenomatous polyps as the main precursors. Standard colonoscopy is the gold standard, but its effectiveness is limited by operator variability and m...