Dual crisis: environmental and economic unsustainability in NHS dry eye prescribing [0.03%]
双重危机：NHS干眼处方的环境和经济不可持续性
Jack Ao,Saaeha Rauz,Anat Galor et al.
Jack Ao et al.
Randomised, double-masked trial to compare the efficacy, safety and immunogenicity of the biosimilar aflibercept FYB203 with reference aflibercept in patients with neovascular age-related macular degeneration [0.03%]
与原研产品对比，评价阿柏西普生物类似药FYB203治疗湿性年龄相关性黄斑变性的有效性和安全性多中心、随机、双盲III期临床试验
Sigrid Balser,Björn Capsius,Rahul Hole et al.
Sigrid Balser et al.
Objective: Biosimilars are helping to reduce the cost burden of treatment and widen patient access to therapies. This multicentre trial compared the efficacy, safety and immunogenicity of the biosimilar aflibercept FYB203...
Randomized Controlled Trial
BMJ open ophthalmology. 2026 Jan 5;11(1):e002398. DOI:10.1136/bmjophth-2025-002398 2026
Réjane Mairesse,Marianne Lepetit,Charlotte Dubucs et al.
Réjane Mairesse et al.
Objective: The purpose of this study was to describe reports of congenital eye anomalies entered in the international pharmacovigilance database, with a particular focus on medications associated with this type of anomaly...
Phase 1 dose-escalation study of IBI324, a VEGF-A/Ang-2 bispecific antibody, for the treatment of diabetic macular oedema [0.03%]
伊布司替尼(IBI324，VEGF-A/ Ang-2双特异性抗体)治疗糖尿病性黄斑水肿I期剂量递增研究
Zilin Wang,Junran Sun,Kun Liu et al.
Zilin Wang et al.
Objective: To evaluate the safety, tolerability and preliminary efficacy of IBI324, a vascular endothelial growth factor-A/angiopoietin-2 bispecific antibody, in participants with diabetic macular oedema (DME). ...
Modelling direct healthcare costs for screening and treatment of retinopathy of prematurity among infants born at gestational age [0.03%]
极低胎龄儿早产视网膜病变筛查与治疗的直接医疗费用测算模型
Chatarina Löfqvist,Shambhavi Sharma,Ann Hellström et al.
Chatarina Löfqvist et al.
Objective: Sweden has a long-standing tradition of actively managing infants born extremely preterm at 22-23 weeks' gestational age. This study analyses screening and treatment pathways for retinopathy of prematurity (ROP...
Gas versus GaslEss surgery for full thickness Macular hole (GEM): study protocol for a randomised, assessor-masked, surgical feasibility study [0.03%]
气体与无气化玻璃体切割手术治疗全层黄斑孔的可行性研究方案：一项随机、评估者盲法外科手术试验
George S P Murphy,Hatem A Wafa,Maryrose Tarpey et al.
George S P Murphy et al.
Introduction: Pars plana vitrectomy with intravitreal gas tamponade has been the standard treatment for full-thickness macular holes (FTMHs) for the last 30 years. Gas tamponade has multiple drawbacks: it results in very ...
Violet light-transmitting intraocular lens increases choroidal thickness: 1-year prospective, randomised controlled trial [0.03%]
一种可透紫光的房水通道型人工晶状体增加脉络膜厚度：一项为期一年的前瞻性随机对照试验
Erisa Yotsukura,Hidemasa Torii,Ken Hayashi et al.
Erisa Yotsukura et al.
Aims: To compare the changes in ocular parameters after implantation of two types of intraocular lenses (IOLs) following cataract surgery. One IOL transmits violet light (VL), and the other does not. ...
Randomized Controlled Trial
BMJ open ophthalmology. 2025 Dec 10;10(1):e002441. DOI:10.1136/bmjophth-2025-002441 2025
Establishing non-inferiority margins in myopia management contact lens trials with an active control [0.03%]
使用活性控制的近视管理隐形眼镜试验中非劣效性边界的建立
Ravi Chandra Bakaraju,Daniel Tilia
Ravi Chandra Bakaraju
The myopia control field stands at an ethical crossroads. Withholding proven soft contact lens interventions in control arms of myopia management trials is increasingly viewed as ethically questionable and operationally challenging, particu...
Evaluating the diagnostic reasoning of large language models in complex neuro-ophthalmological cases: a comparative analysis of GPT-o1 Pro, GPT-4o, Gemini, Grok 2 and DeepSeek [0.03%]
大型语言模型在复杂神经眼科病例诊断推理中的评估：GPT-o1 Pro、GPT-4o、Gemini、Grok 2和DeepSeek的比较分析
Fang-Fang Zhao,Hu Zhan-Chi,Jia-Jian Liang et al.
Fang-Fang Zhao et al.
Purpose: This study aims to evaluate and compare the diagnostic reasoning of five large language models (LLMs) in complex neuro-ophthalmological cases. We assessed the performance of GPT-o1 Pro, GPT-4o, Google Gemini, Gro...
Comparative Study
BMJ open ophthalmology. 2025 Dec 4;10(1):e002185. DOI:10.1136/bmjophth-2025-002185 2025
Impact of complications in adult anterior uveitis in a Finnish single-centre registry study [0.03%]
芬兰单中心登记研究中成人前葡萄膜炎并发症的影响
Aada Leino,Mira Siiskonen,Pasi Ohtonen et al.
Aada Leino et al.
Objective: To analyse ocular complications, their surgical treatments and risk factors in anterior uveitis (AU). Methods and analysis: ...