Establishing non-inferiority margins in myopia management contact lens trials with an active control [0.03%]
使用活性控制的近视管理隐形眼镜试验中非劣效性边界的建立
Ravi Chandra Bakaraju,Daniel Tilia
Ravi Chandra Bakaraju
The myopia control field stands at an ethical crossroads. Withholding proven soft contact lens interventions in control arms of myopia management trials is increasingly viewed as ethically questionable and operationally challenging, particu...
Evaluating the diagnostic reasoning of large language models in complex neuro-ophthalmological cases: a comparative analysis of GPT-o1 Pro, GPT-4o, Gemini, Grok 2 and DeepSeek [0.03%]
大型语言模型在复杂神经眼科病例诊断推理中的评估：GPT-o1 Pro、GPT-4o、Gemini、Grok 2和DeepSeek的比较分析
Fang-Fang Zhao,Hu Zhan-Chi,Jia-Jian Liang et al.
Fang-Fang Zhao et al.
Purpose: This study aims to evaluate and compare the diagnostic reasoning of five large language models (LLMs) in complex neuro-ophthalmological cases. We assessed the performance of GPT-o1 Pro, GPT-4o, Google Gemini, Gro...
Comparative Study
BMJ open ophthalmology. 2025 Dec 4;10(1):e002185. DOI:10.1136/bmjophth-2025-002185 2025
Impact of complications in adult anterior uveitis in a Finnish single-centre registry study [0.03%]
芬兰单中心登记研究中成人前葡萄膜炎并发症的影响
Aada Leino,Mira Siiskonen,Pasi Ohtonen et al.
Aada Leino et al.
Objective: To analyse ocular complications, their surgical treatments and risk factors in anterior uveitis (AU). Methods and analysis: ...
Drug-induced immune-mediated uveitis: a real-world pharmacovigilance analysis using FAERS and JADER databases [0.03%]
基于FAERS和JADER数据库的药物诱发免疫介导性葡萄膜炎的药物流行病学研究
Shanshan Xu,Zhihui Song,Yiman Li et al.
Shanshan Xu et al.
Purpose: To analyse drug-associated immune-mediated uveitis (IMU) risk using large-scale pharmacovigilance data. Methods: We conducted ...
Associations between estimated glucose disposal rate and age-related ocular diseases in cardiovascular-kidney-metabolic syndrome stages 0-3: a large prospective cohort study [0.03%]
心血管-肾脏-代谢综合征0～3期估算葡萄糖处置速率与年龄相关性眼病的关联：一项大型前瞻性队列研究
Linge Jian,Zhiqian Huang,Jiao Qi et al.
Linge Jian et al.
Objective: This study investigated the relationship between estimated glucose disposal rate (eGDR) and the risk of age-related ocular diseases, including macular degeneration, glaucoma, cataracts, diabetic retinopathy (DR...
Enhancing AI-based diabetic retinopathy diagnosis through universal cross-camera image adaptation [0.03%]
基于AI的糖尿病视网膜病变诊断的跨相机图像适配方法研究
Sanil Joseph,Xiaotian Chen,Chi Liu et al.
Sanil Joseph et al.
Objective: To evaluate the effectiveness of a deep learning-based style adaptation strategy in improving the diagnostic accuracy and cross-camera generalisability of artificial intelligence (AI) for detecting diabetic ret...
Automated quantification of retinal non-perfusion areas in ultra-widefield SS-OCTA image of patient with retinal vascular diseases by NP-Unet model [0.03%]
基于NP-Unet模型的超广角扫频型光学 coherence tomography angiography图像视网膜缺血区自动化定量评估方法研究
Yanjie Zhu,Yuting Liao,Jianying Pan et al.
Yanjie Zhu et al.
Purpose: Retinal non-perfusion areas (NPAs) are a crucial biomarker for assessing the degree of retinal ischaemia of patients with retinal vascular diseases. Accurate identification of NPA is useful for assessing therapeu...
Evaluating continuous curvilinear capsulorhexis proficiency via video analysis [0.03%]
通过视频分析评估连续圆曲形囊膜切开术的熟练度
Jing Dong,Yating Xu,Hongda Gong et al.
Jing Dong et al.
Purpose: Continuous curvilinear capsulorhexis (CCC) quality affects posterior capsule opacification and visual outcomes after cataract surgery. We developed a novel metric, the Capsulotomy Proficiency Index (CPI), to obje...
Defocus Incorporated Multiple Segments (DIMS) spectacle lenses versus 0.01% atropine for myopia control: a randomised trial in children from Central Europe [0.03%]
儿童散焦离散分段(r.d.f.)眼镜与0.01%阿托品控制屈光不正的随机临床试验欧洲中心地区的儿童
Emilia Wnękowicz-Augustyn,Edward Wylęgała,Martyna Kobielnik et al.
Emilia Wnękowicz-Augustyn et al.
Background/aims: The global increase in childhood myopia underscores the need for effective control strategies. This study compares the effectiveness of Defocus Incorporated Multiple Segments (DIMS) spectacle lenses versu...
Randomized Controlled Trial
BMJ open ophthalmology. 2025 Nov 11;10(1):e002329. DOI:10.1136/bmjophth-2025-002329 2025
Comparative outcomes of aflibercept biosimilars and reference aflibercept in nAMD: a systematic review and meta-analysis [0.03%]
阿柏西普生物仿制药与原研药治疗nAMD的临床结局比较：系统评价和meta分析
Korolos Sawires,Harrish Nithianandan,Sohel Somani
Korolos Sawires
Objective: To evaluate the literature-pooled functional, anatomical and safety outcomes of aflibercept biosimilars compared with reference aflibercept for neovascular age-related macular degeneration (nAMD). ...