A Phase II study of avenciguat, a novel soluble guanylate cyclase activator, in patients with systemic sclerosis: Study design and rationale of the VITALISScE™ study [0.03%]
Avenciguat（一种新型可溶性鸟苷酸环化酶激活剂）用于系统性硬化症患者的II期研究：VITALISScE™ 研究的设计与原理
Dinesh Khanna,Jeska de Vries-Bouwstra,Anna-Maria Hoffmann-Vold et al.
Dinesh Khanna et al.
Introduction: Systemic sclerosis is a rare autoimmune connective tissue disease characterised by (1) microvasculopathy; (2) immune dysregulation; and (3) progressive fibrosis of the skin and internal organs. Soluble guany...
An evaluation of autonomic and gastrointestinal symptoms, and gastric emptying, in patients with systemic sclerosis [0.03%]
系统性硬化症患者自主神经和胃肠道症状以及胃排空的评估
Michael Hughes,Elizabeth Harrison,Ariane L Herrick et al.
Michael Hughes et al.
Objective: Assessment of gastrointestinal and autonomic symptoms in patients with systemic sclerosis, and possible associations with gastric emptying rate. ...
Design of CONQUEST, a novel, randomized, placebo-controlled, Phase 2b platform clinical trial to investigate new treatments for patients with early active systemic sclerosis with interstitial lung disease [0.03%]
CONQUEST试验设计：一项针对早期活动性系统性硬化症间质性肺病患者的新药的随机、安慰剂对照、平台二期临床试验
Dinesh Khanna,Luke B Evnin,Shervin Assassi et al.
Dinesh Khanna et al.
Objective: Safe, effective therapies are urgently needed for patients with systemic sclerosis. However, clinical trial recruitment is challenging given the limited number of people with systemic sclerosis and further rest...
Peer mentoring program through a digital platform for people with systemic sclerosis: A feasibility study [0.03%]
基于数字平台的硬皮病患者同伴辅导项目可行性研究
Yen T Chen,Nirali Shah,Mary Alore et al.
Yen T Chen et al.
Objective: People with systemic sclerosis (SSc or scleroderma), a rare chronic autoimmune disease, often face significant physical and emotional challenges. Peer mentoring, where someone with similar lived experiences off...
Efficacy and safety of digital nerve block for pain management during sharp debridement of digital ulcers in systemic sclerosis: A prospective observational study [0.03%]
数字溃疡锐性清创术期间系统性硬化症患者数字神经阻滞镇痛的有效性和安全性：前瞻性观察研究
Riccardo Bixio,Francesca Mastropaolo,Francesca Nava et al.
Riccardo Bixio et al.
Introduction: Systemic sclerosis (SSc) is a chronic autoimmune disease characterized by fibrosis and vascular abnormalities, often leading to the development of digital ulcers (DUs). DUs are painful and debilitating, sign...
What are Juvenile-onset systemic sclerosis providers thoughts, experiences, and reasons for autologous stem cell transplant? Result of a multinational survey [0.03%]
儿童期系统性硬化症自体干细胞移植提供者的思想、经历和原因的多国调查结果
Ivan Foeldvari,Samantha Branton,Suzanne C Li et al.
Ivan Foeldvari et al.
Objective: Juvenile-onset systemic sclerosis (jSSc) is a rare and life-threatening disease with no formal studies evaluating the indications for, access to, or benefits of autologous stem cell transplantation (ASCT). As a...
Prevalence, causes, and clinical associations of anemia in patients with systemic sclerosis: A cohort study [0.03%]
系统性硬化病患者贫血的流行率、原因及临床特征：队列研究
Benoit Gachet,Mathieu Jouvray,Vincent Koether et al.
Benoit Gachet et al.
Background: Anemia is considered a risk factor of severity in systemic sclerosis. Yet, limited data are available on the frequency and causes of anemia in systemic sclerosis. The objectives of our study were to determine ...
Troponin I levels in systemic sclerosis patients with myocardial involvement [0.03%]
系统性硬化病合并心肌病变患者的肌钙蛋白I水平
Eva M Hoekstra,Sophie Ie Liem,Saad Ahmed et al.
Eva M Hoekstra et al.
Objectives: Troponin I has been suggested as a more specific diagnostic biomarker for myocardial involvement in systemic sclerosis than the frequently used troponin T. The aim of this study is to evaluate the additive val...
Can machine learning assist in systemic sclerosis diagnosis and management? A scoping review [0.03%]
机器学习能协助系统性硬化症的诊断和管理吗？一项范围综述
Eric P McMullen,Rajan S Grewal,Kyle Storm et al.
Eric P McMullen et al.
This scoping review aims to summarize the existing literature on how machine learning can be used to impact systemic sclerosis diagnosis, management, and treatment. Following Preferred Reporting Items for Systematic reviews and Meta-Analyse...
De-Arne Samm,Aimee Macoustra,Rhiannon Crane et al.
De-Arne Samm et al.
Background and aims: Systemic sclerosis is a debilitating inflammatory condition synonymous with gastrointestinal symptoms which have the potential to impact dietary intake and nutritional status. This study aimed to desc...