Tissue-specific DNA isolation from dissected millipedes for nanopore sequencing [0.03%]
用于纳米孔测序的解剖马陆的组织特异性DNA分离
Elena Cruz,William Wittstock,Bruce A Snyder et al.
Elena Cruz et al.
There are approximately 12,000 described species within the class Diplopoda. Only five species, falling within 4 of 16 described orders, have fully sequenced genomes. No whole genomes are available for incredibly diverse families like Xysto...
Optimization of computational ancestry inference for use in cancer cell lines [0.03%]
计算推断在癌症细胞系中使用的谱系祖先的优化方法
Matthew S Chang,Katherine A Martinez,Chayil C Lattimore et al.
Matthew S Chang et al.
Cancer cell lines have provided invaluable preclinical mechanistic data for cancer health disparities research. Although there are several studies that detail ancestry inference methods using microarray data, there are none that provide inv...
Convolutional-LSTM approach for temporal catch hotspots (CATCH): an AI-driven model for spatiotemporal forecasting of fisheries catch probability densities [0.03%]
基于卷积长短时记忆网络的渔获时空概率密度预测模型：以渤海为例
Altair Agmata,Svanur Guðmundsson
Altair Agmata
Efficient fisheries management is crucial for sustaining both marine ecosystems and the economies that heavily depend on them, such as Iceland. Current fishing practices involve decisions informed by a combination of personal experience, cu...
KD_MultiSucc: incorporating multi-teacher knowledge distillation and word embeddings for cross-species prediction of protein succinylation sites [0.03%]
基于多教师知识蒸馏和词嵌入的跨物种蛋白质琥珀酰化位点预测方法
Thi-Xuan Tran,Thi-Tuyen Nguyen,Nguyen-Quoc-Khanh Le et al.
Thi-Xuan Tran et al.
Protein succinylation is a vital post-translational modification (PTM) that involves the covalent attachment of a succinyl group (-CO-CH2-CH2-CO-) to the lysine residue of a protein molecule. The mechanism underlying the succinylation proce...
Kanon Maruyama,Hodaka Fujii
Kanon Maruyama
Cells respond to environmental stresses such as cold and osmotic stresses. These stresses induce signal transduction pathways in cells. However, the molecular mechanisms activated by cold and osmotic stresses in higher eukaryotes remain elu...
Rough microsomes isolated from snap-frozen canine pancreatic tissue retain their co-translational translocation functionality [0.03%]
快速冻结狗胰腺组织的粗微粒体保留其共翻译转运功能
Marianne Croonenborghs,Marijke Verhaegen,Eva Pauwels et al.
Marianne Croonenborghs et al.
Proteins are essential for life in all organisms: they mediate cell signaling and cell division and provide structure/motility to cells and tissues. All proteins are synthesized on cytoplasmic ribosomes as unfolded precursors that need to f...
Ana Paula Carvalho Reis,Giovanna Azevedo Celestrino,Talita Souza Siqueira et al.
Ana Paula Carvalho Reis et al.
The skin is the largest organ in the body and is the site for a diverse set of diseases. Yet, given the complexity of the cutaneous tissue, there is a limited availability of data in the literature on skin proteomics. Here, we proposed an a...
Neuro293: A REST-knockout HEK-293 cell line enables the expression of neuron-restricted genes for the high-throughput testing of human neurobiology and the biochemistry of neuronal proteins [0.03%]
神经元REST敲除HEK-293细胞系可高通量表达神经元特异性基因，用于人类神经生物学和神经蛋白生化的研究
Joshua T Moses,Fahad B Shah,Nicholas M McVay et al.
Joshua T Moses et al.
Efficient interrogation of neurobiology remains bottlenecked by obtaining mature neurons. Immortalized cell lines still require lengthy differentiation periods to obtain neuron-like cells, which may not efficiently differentiate and are cha...
Enhancing leptospirosis screening using a deep convolutional neural network with microscopic agglutination test images [0.03%]
基于微观凝集试验图像的深度卷积神经网络钩端螺旋体筛查改进方法研究
Murnihayati Hassan,Siti Nur Zawani Rosli,Natasya Amirah Mohamed Tahir et al.
Murnihayati Hassan et al.
Leptospirosis poses substantial challenges to global public health. In Malaysia, leptospirosis is endemic, with annual cases peaking during the monsoon season. The microscopic agglutination test (MAT) is the gold-standard serological method...
DrugPipe: Generative artificial intelligence-assisted virtual screening pipeline for generalizable and efficient drug repurposing [0.03%]
药物重定位的通用且高效的生成式人工智能辅助虚拟筛选工作流程DrugPipe
Phuc Pham,Viet Thanh Duy Nguyen,Kyu Hong Cho et al.
Phuc Pham et al.
Drug repurposing presents a promising strategy to accelerate drug discovery by identifying new therapeutic uses for existing compounds, particularly for diseases with limited or no effective treatment options. We introduce DrugPipe, a 'Gene...