Semaglutide use linked to lower COVID-19 and influenza severity with better renal outcomes after pandemic or seasonal infection [0.03%]
司美格鲁肽的使用与大流行或季节性感染后的新冠肺炎和流感严重程度降低及更好的肾脏结局相关
Robert Matson,A J Venkatakrishnan,Karthik Murugadoss et al.
Robert Matson et al.
Respiratory viral infections continue to impose a large burden of hospitalization, organ failure and death, particularly among older adults and people with cardiometabolic disease. Whether prior semaglutide exposure is associated with lower...
Investigating the efficacy of skin swabbing as a minimally invasive method of genetic sampling from Indian amphibians [0.03%]
调查皮肤拭擦作为从印度两栖动物中采集遗传样本的微创方法的有效性
G Vaibhavi,C K Aravind,Shashank K Borkar et al.
G Vaibhavi et al.
Amphibians are facing an unprecedented extinction crisis; 41% of the species are currently on the verge of extinction, making them among the most threatened vertebrates. One of the integral components in amphibian conservation is genetic re...
Co-culture of bone marrow-derived macrophages with aged primary myoblasts [0.03%]
骨髓源性巨噬细胞与老龄原代肌管的共培养
Ryan Arsenault,Anthony Ziadeh,Alexander Green et al.
Ryan Arsenault et al.
Skeletal muscle regeneration depends on the coordinated activity of multiple cell populations within the muscle stem cell niche, most prominently macrophages, which undergo dynamic phenotypic transitions essential to tissue repair. Aging di...
EEG-based AI-BCI wheelchair advancement: Transformer-based learning with motor imagery for brain computer interface [0.03%]
基于EEG的AI-BCI轮椅技术进步：使用运动想象的Transformer学习在脑机接口中的应用
Bipul Thapa,Biplov Paneru,Bishwash Paneru et al.
Bipul Thapa et al.
This article presents an artificial intelligence integrated approach to brain-computer interface-based wheelchair development, utilizing a motor imagery right-left-hand movement mechanism for control. The system is designed to simulate whee...
Selective elimination of donor bacteria to analyze plasmid reactions during conjugative transfer [0.03%]
选择性消除供菌以分析接合转移过程中质粒的反应
Meng Wen,Emma Mettouchi,Alejandra López Sánchez et al.
Meng Wen et al.
Bacterial conjugation is an important means of horizontal gene transfer in which DNA is transferred from a donor to a recipient cell by direct cell-to-cell contact. Dissemination of antibiotic resistance in bacteria is very often driven by ...
A simple suspension culture method for generating human iPSC-derived liver organoids [0.03%]
一种简单的人多能干细胞来源肝类器官的悬浮培养方法
Ryosuke Morozumi,Mawo Kinoshita,Ryo Takahashi et al.
Ryosuke Morozumi et al.
Human liver in vitro models are indispensable for toxicity studies requiring metabolic competence. However, widely used two-dimensional hepatocyte-derived cell lines exhibit limited drug-metabolizing capacity, whereas primary human hepatocy...
Auditable large language model curation of clinical notes refines glucagon-like peptide-1 initiation, persistence ascertainment, and compounding use beyond prescription records [0.03%]
可审计的大语言模型对临床笔记的管理完善了胰高血糖素样肽-1的启动、持续确认和复合使用，超出了处方记录范围
Gowtham Varma,Karthik Murugadoss,Mathews E Kurian et al.
Gowtham Varma et al.
Real-world benefit from incretin-based therapies depends on actual treatment initiation and sustained exposure, yet structured prescription records may capture prescribing intent rather than confirmed use. Using a large federated, de-identi...
Enhanced drug-disease association prediction through representation learning on similarity networks [0.03%]
基于相似网络的表示学习增强的药物-疾病关联预测方法
Duc-Hau Le
Duc-Hau Le
Drug repositioning has emerged as a promising strategy for accelerating therapeutic discovery by identifying novel indications for existing drugs. Recent graph representation learning methods have shown encouraging performance for drug-dise...
Transmission electron microscopy of cultured cells: Optimized protocols for ultrastructural studies and post-embedding immunogold labeling [0.03%]
透射电镜观察培养细胞：亚细胞结构的研究及免疫电镜的优化方法
Anna Richert,Robert Lenartowski,Jolanta Nowak et al.
Anna Richert et al.
Nanometer-scale localization of specific proteins within cells is essential for understanding their roles in diverse physiological and pathological cellular processes. Such high-resolution localization of protein epitopes can be achieved by...
Cannabinoid GPCRs, ectopic olfactory GPCRs and TRP channels: a prespecified baseline-edit-rescue framework for testing higher-order membrane-conditioned integration [0.03%]
cannabinoid G 蛋白偶联受体、异位嗅觉G蛋白偶联受体和瞬态感受器电位通道：用于测试更高阶的膜条件整合的预设基线编辑救援框架
Erhan Yarar
Erhan Yarar
Cell membranes are not mere platforms for signalling proteins; they can shape how receptor inputs are assembled into local responses. In membrane-rich microdomains, receptor identification and pathway mapping do not reveal the logic of a me...