An explainable AI approach for mapping multivariate regional brain age and clinical severity patterns in Alzheimer's disease [0.03%]
一种用于绘制阿尔茨海默病多变量区域脑年龄和临床严重程度模式的可解释人工智能方法
Gauri Darekar,Taslim Murad,Hui-Yuan Miao et al.
Gauri Darekar et al.
Age is a significant risk factor for mild cognitive impairment (MCI) and Alzheimer's disease (AD) and identifying brain age patterns is critical for comprehending the normal aging and MCI/AD processes. Prior studies have widely established ...
Innovative approach for the qualitative-quantitative assessment of neurodevelopment biomarkers research in placenta tissue using immunohistochemistry digital image analysis [0.03%]
一种用于胎盘组织神经发育生物标志物研究的定性定量创新评估方法——使用免疫组化数字图像分析技术
Caroline Camilo,Luana Martos Vieira,Gisele Rodrigues Gouveia et al.
Caroline Camilo et al.
We aimed to develop and validate a standardized, qualitative-quantitative protocol for digital IHC analysis to assess neurodevelopmental biomarkers in placental tissue. Placental tissues from 60 births were obtained from the Western Region ...
Application of dicentric chromosome assay for evaluation of radioprotective effect [0.03%]
用dicentric染色体检测法评价放射防护效果
Marcela Milanová,Vojtěch Chmil,Aleš Tichý et al.
Marcela Milanová et al.
The dicentric chromosome assay is a well-established biodosimetric method used to assess absorbed ionizing radiation doses by detecting dicentric chromosomal aberrations. Here, we present a detailed, reproducible protocol for applying the d...
Reassessing deep learning (and meta-learning) computer vision as an efficient method to determine taphonomic agency in bone surface modifications [0.03%]
重新评估深度学习（和元学习）计算机视觉在确定骨骼表面修改中的埋藏学行为的有效性方法
Manuel Domínguez-Rodrigo,Gabriel Cifuentes-Alcobendas,Marina Vegara-Riquelme et al.
Manuel Domínguez-Rodrigo et al.
Taphonomic research aims at reconstructing processes affecting the preservation and modification of paleobiological entities. Recent critiques of the reliability of deep learning (DL) for taphonomic analysis of bone surface modifications (B...
An optimized zebrafish obesogenic test protocol with an artificial intelligence-based analysis software for screening obesogens and anti-obesogens [0.03%]
一种优化的斑马鱼肥胖诱导测试方案及其基于人工智能分析软件的筛查方法用于筛选增胖因子及抗肥胖干扰物
Sara Al Kassir,Théo Mercé,Sandra Pedemay et al.
Sara Al Kassir et al.
Obesity is defined as a disease in which abnormal excessive body fat accumulation causes adverse effects on health. One proposed contributing factor to the rise in obesity is the exposure to endocrine disruptors acting as obesogens. Semitra...
A simple, cost-effective, method for creating electronic cigarette vapor condensate [0.03%]
一种简单廉价的生成电子烟油冷凝液的方法
Jennifer M Piechowski,Brian Bagatto
Jennifer M Piechowski
Methods to create electronic cigarette (e-cigarette) vapor condensate are needed for use in e-cigarette vapor exposure studies. There are currently several methods to produce condensate described in the literature, but they are often cost-p...
A prospective cohort study to develop multi-biomarkers panel to define biological ageing in six different cohorts from newborn to oldest adult: a study protocol [0.03%]
一种前瞻性队列研究，开发多种生物标志物集合来定义从新生儿到最高龄成人六种不同队列的生物学衰老：一项研究方案
Prasun Chatterjee,Rashi Jain,Pooja Attri et al.
Prasun Chatterjee et al.
Age-associated disease management depends significantly on chronological age and macro-level clinical data sets. However, the biological age captures bio-physiological deterioration more precisely than the chronological age. Biological agei...
AllerTrans: a deep learning method for predicting the allergenicity of protein sequences [0.03%]
AllerTrans：一种用于预测蛋白质序列过敏性的深度学习方法
Faezeh Sarlakifar,Hamed Malek,Najaf Allahyari Fard
Faezeh Sarlakifar
Allergens are a major concern in determining protein safety, especially with the growing use of recombinant proteins in new medical products. These proteins require a careful allergenicity assessment to guarantee their safety. However, trad...
Cost-effective production of Escherichia coli "GABase" for spectrophotometric determination of γ-aminobutyrate (GABA) levels or glutamate decarboxylase activity [0.03%]
低成本的大肠杆菌"GABase"的制备及其在测定γ-氨基丁酸含量和谷氨酸脱羧酶活性中的应用
Kirsten H Benidickson,Kyle F Symonds,Wayne A Snedden et al.
Kirsten H Benidickson et al.
γ-aminobutyrate (GABA) is a non-proteinogenic amino acid produced by glutamate decarboxylase (GAD) that functions as a vital neurotransmitter in animals, and as an important metabolite and signaling molecule in plants and microbes. "GABase...
Advances and future directions of aptamer-functionalized nanoparticles for point-of-care diseases diagnosis [0.03%]
适配体功能化纳米颗粒的最新研究进展及其在床边疾病诊断中的应用展望
Ilemobayo Victor Fasogbon,Erick Nyakundi Ondari,Deusdedit Tusubira et al.
Ilemobayo Victor Fasogbon et al.
Point-of-care (POC) diagnostics have revolutionized disease detection by enabling rapid, on-site testing without the need for centralized laboratory infrastructure. This review presents recent advances in aptamer-functionalized nanoparticle...