A window of opportunity trial evaluating intratumoral injection of Copaxone® in patients with percutaneously accessible tumors [0.03%]
Copaxone®瘤内注射治疗可经皮注射肿瘤患者的Ⅱ期临床试验
Joaquina C Baranda,Ghulam Rehman Mohyuddin,Andrés M Bur et al.
Joaquina C Baranda et al.
Background: This window of opportunity trial evaluated the safety of intratumoral Copaxone® and profiled immune markers in biopsies before and after treatment. ...
Plasma proteomes of acute myeloid leukemia patients treated with transfusions reveal signatures of inflammation and hemostatic dysregulation [0.03%]
接受输血治疗的急性髓系白血病患者的血浆蛋白质组显示炎症和止血失调的标志物
Eva R Smit,Diana Muñoz Sandoval,Iris C Kreft et al.
Eva R Smit et al.
Background: Bone marrow aplasia is a common feature in acute myeloid leukemia (AML) patients during their remission induction treatment, and is associated with potential complications such as bleeding, infection and anemi...
Plasma galectin-9 levels correlate with blood monocyte turnover and predict simian/human immunodeficiency virus disease progression [0.03%]
血浆半乳糖凝集素9水平与血液单核细胞周转及.simian/人类免疫缺陷病毒疾病进展预测有关
Laurent Zablocki-Thomas,Amir Ardeshir,Naofumi Takahashi et al.
Laurent Zablocki-Thomas et al.
Background: Late-stage human immunodeficiency virus (HIV) infection is typically characterized by low CD4 + T-cell count. We previously showed that profound changes in the monocyte turnover (MTO) rate in rhesus macaques i...
The combined treatment with ketogenic diet and metformin slows tumor growth in two mouse models of triple negative breast cancer [0.03%]
一种酮体生饮食和二甲双胍联合治疗可减缓三阴性乳腺癌小鼠模型的肿瘤生长
Karen Schmidt,Amber Thatcher,Albert Grobe et al.
Karen Schmidt et al.
Background: Many tumors contain hypoxic microenvironments caused by inefficient tumor vascularization. Hypoxic tumors have been shown to resist conventional cancer therapies. Hypoxic cancer cells rely on glucose to meet t...
Organizational aspects of tissue engineering clinical translation: insights from a qualitative case study [0.03%]
组织工程临床转化的组织方面：定性案例研究的启示
Renan Gonçalves Leonel da Silva,Larry Au,Alessandro Blasimme
Renan Gonçalves Leonel da Silva
Background: Tissue engineering is a multidisciplinary field that combines principles from cell biology, bioengineering, material sciences, medicine and surgery to create functional and viable bioproducts that can be used ...
Animesh Acharjee
Animesh Acharjee
Characterization of lamina propria remodeling in pediatric eosinophilic esophagitis using second harmonic generation microscopy [0.03%]
二次谐波生成显微镜在儿童嗜酸性食管炎固有层重建表征中的应用研究
Ezekiel J Haugen,Andrea K Locke,Hernán Correa et al.
Ezekiel J Haugen et al.
Eosinophilic esophagitis (EoE) is a chronic inflammatory condition characterized by an intense infiltration of eosinophils into the esophageal epithelium. When not adequately controlled, eosinophilic inflammation can lead to changes in comp...
Accessing and utilizing clinical and genomic data from an electronic health record data warehouse [0.03%]
从电子健康记录数据仓库中获取和利用临床基因组数据
Cosby G Arnold,Brandon Sonn,Frederick J Meyers et al.
Cosby G Arnold et al.
Electronic health records (EHRs) and linked biobanks have tremendous potential to advance biomedical research and ultimately improve the health of future generations. Repurposing EHR data for research is not without challenges, however. In ...
Circulating neutrophil extracellular trap (NET)-forming 'rogue' neutrophil subset, immunotype [DEspR + CD11b +], mediate multi-organ failure in COVID-19- an observational study [0.03%]
一项观察性研究：COVID-19 中循环的 NET 形成“异常”中性粒细胞亚群[ DEspR+CD11b+]介导多器官功能障碍
Victoria L M Herrera,Nicholas A Bosch,Judith J Lok et al.
Victoria L M Herrera et al.
Background: Cumulative research show association of neutrophils and neutrophil extracellular traps (NETs) with poor outcomes in severe COVID-19. However, to date, there is no curative intent therapy able to block neutroph...
Oncolytic virus-based suicide gene therapy for cancer treatment: a perspective of the clinical trials conducted at Henry Ford Health [0.03%]
基于溶瘤病毒的自杀基因癌症治疗：亨利·福特医疗中心开展的临床试验透视观点论文
Shivani Thoidingjam,Sushmitha Sriramulu,Svend Freytag et al.
Shivani Thoidingjam et al.
Gene therapy manipulates or modifies a gene that provides a new cellular function to treat or correct a pathological condition, such as cancer. The approach of using gene manipulation to modify patient's cells to improve cancer therapy and ...