Studies of postpartum mammary gland involution reveal novel pro-metastatic mechanisms [0.03%]
产后乳腺退行性研究揭示了新的促转移机制
Taylor R Wallace,Sarah E Tarullo,Lyndsey S Crump et al.
Taylor R Wallace et al.
Postpartum involution is the process by which the lactating mammary gland returns to the pre-pregnant state after weaning. Expression of tumor-promotional collagen, upregulation of matrix metalloproteinases, infiltration of M2 macrophages, ...
A non-toxic approach for treatment of breast cancer and its metastases: capecitabine enhanced photodynamic therapy in a murine breast tumor model [0.03%]
一种治疗乳腺癌及其转移的方法：在小鼠乳腺肿瘤模型中采用卡培他滨增强的光动力疗法
Sanjay Anand,Anton Yasinchak,Taylor Bullock et al.
Sanjay Anand et al.
Aim: Breast cancer (BCA) in women is a leading cause of mortality and morbidity; distant metastases occur in ~40% of cases. Here, as an alternative to ionizing radiation therapy and chemotherapy and their associated side ...
Centrosome aberrations and chromosome instability contribute to tumorigenesis and intra-tumor heterogeneity [0.03%]
中心体异常和染色体不稳定性促进肿瘤发生及瘤内异质性生成
Shirley Jusino,Fabiola M Fernández-Padín,Harold I Saavedra
Shirley Jusino
Centrosomes serve as the major microtubule organizing centers in cells and thereby contribute to cell shape, polarity, and motility. Also, centrosomes ensure equal chromosome segregation during mitosis. Centrosome aberrations arise when the...
Using circulating tumor cells to advance precision medicine in prostate cancer [0.03%]
利用循环肿瘤细胞推动前列腺癌的精准医疗
Giuseppe Galletti,Daniel Worroll,David M Nanus et al.
Giuseppe Galletti et al.
The field of CTC enrichment has seen many emerging technologies in recent years, which have resulted in the identification and monitoring of clinically relevant, CTC-based biomarkers that can be analyzed routinely without invasive procedure...
TGF-β Stimulation of EMT Programs Elicits Non-genomic ER-α Activity and Anti-estrogen Resistance in Breast Cancer Cells [0.03%]
TGF-β诱导的上皮间质转化激活了乳腺癌细胞中的非基因组ER-α活性和抗雌激素耐药性
Maozhen Tian,William P Schiemann
Maozhen Tian
Aim: Estrogen receptor-α (ER-α) activation drives the progression of luminal breast cancers. Signaling by transforming growth factor-β (TGF-β) typically opposes the actions of ER-α; it also induces epithelial-mesench...
DNA damage-induced nuclear factor-kappa B activation and its roles in cancer progression [0.03%]
DNA损伤介导的核因子κB活化及其在癌症进展中的作用
Wei Wang,Arul M Mani,Zhao-Hui Wu
Wei Wang
DNA damage is a vital challenge to cell homeostasis. Cellular responses to DNA damage (DDR) play essential roles in maintaining genomic stability and survival, whose failure could lead to detrimental consequences such as cancer development ...
Withania somnifera extract reduces the invasiveness of MDA-MB-231 breast cancer and inhibits cytokines associated with metastasis [0.03%]
Withania somnifera提取物可降低MDA-MB-231乳腺癌细胞的侵袭性并抑制与转移相关的细胞因子
Kamel F Khazal,Donald L Hill
Kamel F Khazal
Aim: The aim was to examine the anti-proliferative effect of a Withania somnifera (WS) root extract in cell cultures and nude mouse xenografts of breast cancer cell line MDA-MB-231. ...