Matthew P Lierz,Allen Enrique D Siapno,Adam Khorasanchi et al.
Matthew P Lierz et al.
Systemic therapy for metastatic renal cell carcinoma (mRCC) has advanced considerably over the past decade. Studies of systemic therapies in the adjuvant, neoadjuvant, and now perioperative settings as solitary, dual, and triplet combinatio...
Divyanshu Aggarwal,Anita Thyagarajan,Ravi P Sahu
Divyanshu Aggarwal
Lung cancer remains one of the most prevalent and lethal malignancies worldwide, characterized by a poor prognosis and high mortality rates. Although therapeutic strategies targeting oncogenic signaling cascades, such as receptor tyrosine k...
The past, present, and future of targeted therapeutic approaches in patients with diffuse pleural mesotheliomas [0.03%]
弥漫性胸膜间皮瘤患者的靶向治疗现状与未来
Michael Offin,Bailey Fitzgerald,Marjorie G Zauderer et al.
Michael Offin et al.
Despite our growing understanding of the genomic landscape of diffuse pleural mesotheliomas (DPM), there has been limited success in targeted therapeutic strategies for the disease. This review summarizes attempts to develop targeted therap...
Chemoprevention of neuroblastoma: progress and promise beyond uncertainties [0.03%]
神经母细胞瘤的化学预防：在不确定性之外的进步与前景
Natarajan Aravindan,Mohan Natarajan,Dinesh Babu Somasundaram et al.
Natarajan Aravindan et al.
Neuroblastoma is the most common extracranial solid tumor in children and comprises one-tenth of all childhood cancer deaths. The current clinical therapy for this deadly disease is multimodal, involving an induction phase with alternating ...
Dissecting molecular mechanisms of immune microenvironment dysfunction in multiple myeloma and precursor conditions [0.03%]
多发性骨髓瘤及其前体疾病免疫微环境功能障碍的分子机制分析
Maria Moscvin,Benjamin Evans,Giada Bianchi
Maria Moscvin
Multiple myeloma (MM) is a disease of clonally differentiated plasma cells. MM is almost always preceded by precursor conditions, monoclonal gammopathy of unknown significance (MGUS), and smoldering MM (SMM) through largely unknown molecula...
Pancreatic cancer: genetics, disease progression, therapeutic resistance and treatment strategies [0.03%]
胰腺癌：遗传学、疾病进展、治疗抵抗及治疗策略
Karnika Singh,Gauri Shishodia,Hari K Koul
Karnika Singh
Pancreatic cancer is a deadly disease and the third-highest cause of cancer-related deaths in the United States. It has a very low five-year survival rate (< 5%) in the United States as well as in the world (about 9%). The current gemcitabi...
Role of epithelial-mesenchymal transition factor SNAI1 and its targets in ovarian cancer aggressiveness [0.03%]
转分化因子SNAI1及其作用靶点在卵巢癌侵袭性中的功能研究
Tise Suzuki,Ashlyn Conant,Casey Curow et al.
Tise Suzuki et al.
Ovarian cancer remains the most lethal gynecologic malignancy in the USA. For over twenty years, epithelial-mesenchymal transition (EMT) has been characterized extensively in development and disease. The dysregulation of this process in can...
Immune responses elicited by ssRNA(-) oncolytic viruses in the host and in the tumor microenvironment [0.03%]
单链RNA(-)肿瘤溶瘤病毒在宿主体内和肿瘤微环境中诱发的免疫反应
Yonina Bykov,Gloria Dawodu,Aryana Javaheri et al.
Yonina Bykov et al.
Oncolytic viruses (OVs) are at the forefront of biologicals for cancer treatment. They represent a diverse landscape of naturally occurring viral strains and genetically modified viruses that, either as single agents or as part of combinati...
Syaza Salleh,Anita Thyagarajan,Ravi P Sahu
Syaza Salleh
Pancreatic ductal adenocarcinoma (PDAC) is currently the fourth most common cause of cancer-related deaths in the United States. It has a poor prognosis and remains a difficulty to treat malignancy. Over the past several decades, significan...
Victoria Jiminez,Nabiha Yusuf
Victoria Jiminez
The pathophysiology of skin cancer is complex, with multiple factors contributing to its development. The proactive treatment of skin cancer has been investigated in the form of chemoprevention of cutaneous malignancies in clinical trials. ...