Xiangbing Meng,Shujie Yang,Jun Zhang et al.
Xiangbing Meng et al.
Alternative splicing is a major contributor to transcriptome and proteome diversity in eukaryotes. Comparing to normal samples, about 30% more alternative splicing events were recently identified in 32 cancer types included in The Cancer Ge...
hnRNP E1 at the crossroads of translational regulation of epithelial-mesenchymal transition [0.03%]
hnRNP E1在上皮间质转化的翻译调控中起着承上启下的作用
Simon Grelet,Philip H Howe
Simon Grelet
The epithelial-mesenchymal transition (EMT), in which cells undergo a switch from a polarized, epithelial phenotype to a highly motile fibroblastic or mesenchymal phenotype is fundamental during embryonic development and can be reactivated ...
Stem cells, immortality, and the evolution of metastatic properties in breast cancer: telomere maintenance mechanisms and metastatic evolution [0.03%]
乳腺癌的干细胞、永生与转移特性进化：端粒维持机制和转移性进化
Nathaniel J Robinson,Derek J Taylor,William P Schiemann
Nathaniel J Robinson
Breast cancer is the most significant cause of cancer-related death in women around the world. The vast majority of breast cancer-associated mortality stems from metastasis, which remains an incurable disease state. Metastasis results from ...
The IncRNA BORG: A novel inducer of TNBC metastasis, chemoresistance, and disease recurrence [0.03%]
长链非编码RNA BORG通过调节肿瘤细胞的上皮间质转化促进三阴性乳腺癌转移、耐药及复发
Alex J Gooding,Kimberly A Parker,Saba Valadkhan et al.
Alex J Gooding et al.
Although greater than 90% of breast cancer-related mortality can be attributed to metastases, the molecular mechanisms underpinning the dissemination of primary breast tumor cells and their ability to establish malignant lesions in distant ...
Autophagy in breast cancer metastatic dormancy: Tumor suppressing or tumor promoting functions? [0.03%]
自噬在乳腺癌转移性休眠中的作用：抑瘤还是促瘤？
Alyssa La Belle Flynn,William P Schiemann
Alyssa La Belle Flynn
Breast cancer is the second leading cause of cancer-associated death in women in the United States, with more than 90% of those deaths attributed to metastasis. Breast cancer metastasis is incurable and possesses few treatment options and a...
Janice L Farlow,Andrew C Birkeland,Paul L Swiecicki et al.
Janice L Farlow et al.
Head and neck squamous cell carcinoma (HNSCC) has a large global burden of disease and poor survival outcomes. Recent targeted therapies and immunotherapies have been explored in HNSCC, but there has been limited translation to clinical pra...
AF1q inhibited T cell attachment to breast cancer cell by attenuating Intracellular Adhesion Molecule-1 expression [0.03%]
AF1q通过抑制细胞内粘附分子-1表达抑制T细胞与乳腺癌细胞的结合
Jino Park,Jae Yeon Hwang,Alexandra Thore et al.
Jino Park et al.
Aim: To investigate whether AF1q, overexpressed in metastatic cells compared with the primary tumor cells, plays a pivotal role in breast cancer metastasis. ...
A review of the effects of healthcare disparities on the experience and survival of ovarian cancer patients of different racial and ethnic backgrounds [0.03%]
种族和族裔背景不同的卵巢癌患者在治疗过程中遭遇的医疗差异对其经历和生存率影响综述
Matthew Kaufman,Ana Cruz,Janese Thompson et al.
Matthew Kaufman et al.
Ovarian cancer (OC) is a serious condition that often presents at advanced stages and has high mortality rates, with the current mode of early-stage screening lacking sensitivity and specificity. OC often presents asymptomatically, which re...
ESR1 alterations and metastasis in estrogen receptor positive breast cancer [0.03%]
雌激素受体阳性乳腺癌中的ESR1突变和转移
Jonathan T Lei,Xuxu Gou,Sinem Seker et al.
Jonathan T Lei et al.
Endocrine therapy is essential for the treatment of patients with estrogen receptor positive (ER+) breast cancer, however, resistance and the development of metastatic disease is common. Understanding how ER+ breast cancer metastasizes is c...
Metabolic alterations and the potential for targeting metabolic pathways in the treatment of multiple myeloma [0.03%]
代谢改变及针对代谢途径治疗多发性骨髓瘤的潜力
Dustin Rizzieri,Barry Paul,Yubin Kang
Dustin Rizzieri
Metabolism is defined as the collection of complex biochemical processes that living cells use to generate energy and maintain their growth and survival. Metabolism encompasses the synthesis and breakdown of glucose, fatty acids, and amino ...