Christine Happel,Aniruddha Ganguly,Danilo A Tagle
Christine Happel
The discovery that all cells secrete extracellular vesicles (EVs) to shuttle proteins and nucleic acids to recipient cells suggested they play an important role in intercellular communication. EVs are widely distributed in many body fluids,...
Mouse tumor susceptibility genes identify drug combinations for multiple myeloma [0.03%]
小鼠肿瘤易感基因识别多发性骨髓瘤的药物组合方案
Shuling Zhang,Wendy DuBois,Ke Zhang et al.
Shuling Zhang et al.
Long-term genetic studies utilizing backcross and congenic strain analyses coupled with positional cloning strategies and functional studies identified Cdkn2a, Mtor, and Mndal as mouse plasmacytoma susceptibility/resistance genes. Tumor inc...
Guofeng Xie,Jean-Pierre Raufman
Guofeng Xie
Due to the lack of effective treatments, advanced colorectal cancer (CRC) remains a leading cause of cancer death in the United States. Emerging evidence supports the observation that muscarinic receptor (MR) signaling plays a critical role...
M E Heft Neal,C T Haring,J E Mann et al.
M E Heft Neal et al.
Unresectable recurrent or metastatic head and neck cancer is an incurable disease with survival of approximately 12 months. Head and neck tumors exhibit numerous derangements in the tumor microenvironment that aid in immune evasion and may ...
Loss of the Krüppel-like factor 4 tumor suppressor is associated with epithelial-mesenchymal transition in colorectal cancer [0.03%]
Krüppel样因子4肿瘤抑制子的丢失与结直肠癌上皮间质转化有关
Kimberley C Agbo,Jessie Z Huang,Amr M Ghaleb et al.
Kimberley C Agbo et al.
Aim: Colorectal cancer (CRC) is the third leading cancer-related cause of death due to its propensity to metastasize. Epithelial-mesenchymal transition (EMT) is a multistep process important for invasion and metastasis of...
A new view of the mammary epithelial hierarchy and its implications for breast cancer initiation and metastasis [0.03%]
乳腺上皮层次结构的全新观点及其对乳腺癌发生和转移的影响
Lindsey J Anstine,Ruth Keri
Lindsey J Anstine
The existence of mammary epithelial stem cell (MaSC) populations capable of mediating mammary gland development and homeostasis has been established for over a decade. A combination of lineage tracing and mammary gland transplantation studi...
Cellular plasticity and metastasis in breast cancer: a pre- and post-malignant problem [0.03%]
乳腺癌的细胞可塑性和转移：恶性之前和之后的问题
Jacob M Smigiel,Sarah E Taylor,Benjamin L Bryson et al.
Jacob M Smigiel et al.
As a field we have made tremendous strides in treating breast cancer, with a decline in the past 30 years of overall breast cancer mortality. However, this progress is met with little affect once the disease spreads beyond the primary site....
Histone Chaperone FACT and Curaxins: Effects on Genome Structure and Function [0.03%]
组蛋白伴侣FACT和cura化药物：对基因组结构与功能的影响
Han-Wen Chang,Ekaterina V Nizovtseva,Sergey V Razin et al.
Han-Wen Chang et al.
The histone chaperone FACT plays important roles in essentially every chromatin-associated process and is an important indirect target of the curaxin class of anti-cancer drugs. Curaxins are aromatiс compounds that intercalate into DNA and...
Jeremy C Borniger
Jeremy C Borniger
Cancer is a systemic disease. In order to fully understand it, we must take a holistic view on how cancer interacts with its host. The brain monitors and responds to natural and aberrant signals arriving from the periphery, particularly tho...
Two sides to colon cancer: mice mimic human anatomical region disparity in colon cancer development and progression [0.03%]
结肠癌的两面性：小鼠模拟人类结肠癌发病和发展的解剖区域差异性
Jessica Felton,Kunrong Cheng,Aaron C Shang et al.
Jessica Felton et al.
Aim: Strong evidence reveals important differences between cancers in the proximal vs. distal colon. Animal models of metastatic colon cancer are available but with varying degrees of reproducibility and several important...