Pharmacogenomics in colorectal cancer: current role in clinical practice and future perspectives [0.03%]
结直肠癌中的药物基因组学：在临床实践中的当前作用及未来展望
Francesca Battaglin,Alberto Puccini,Madiha Naseem et al.
Francesca Battaglin et al.
The treatment scenario of colorectal cancer (CRC) has been evolving in recent years with the introduction of novel targeted agents and new therapeutic strategies for the metastatic disease. An extensive effort has been directed to the ident...
B cell infiltration is highly associated with prognosis and an immune-infiltrated tumor microenvironment in neuroblastoma [0.03%]
B细胞浸润与神经母细胞瘤预后及免疫浸润性肿瘤微环境高度相关
Evelien Schaafsma,Chongming Jiang,Chao Cheng
Evelien Schaafsma
Aim: Neuroblastoma is the most common extracranial solid tumor in children. Recent advances in immunotherapy Approaches, including in neuroblastoma, have shown the important role of the immune system in mounting an effect...
Lectin-like transcript 1 as a natural killer cell-mediated immunotherapeutic target for triple negative breast cancer and prostate cancer [0.03%]
清道夫受体-like转录物1作为治疗三阴性乳腺癌和前列腺癌的自然杀伤细胞介导免疫治疗靶点
Yuanhong Sun,Joseph D Malaer,Porunelloor A Mathew
Yuanhong Sun
Breast and prostate cancer are the leading causes of death in females and males, respectively. Triple negative breast cancer (TNBC) does not express the estrogen receptor, progesterone receptor, or human epidermal growth factor receptor 2, ...
William P Schiemann
William P Schiemann
Evaluating different routes of extracellular vesicle administration for cranial therapies [0.03%]
评估外泌体的不同给药途径用于颅内治疗的效果
Pericles Ioannides,Erich Giedzinski,Charles L Limoli
Pericles Ioannides
Aim: Human stem cell-derived extracellular vesicles (EV) provide many advantages over cell-based therapies for the treatment of functionally compromised tissue beds and organ sites. Here we aimed to highlight multiple adm...
Multi-layered control of PD-L1 expression in Epstein-Barr virus-associated gastric cancer [0.03%]
EB病毒相关胃癌PD-L1表达的多层调控
Christos N Miliotis,Frank J Slack
Christos N Miliotis
Gastric cancer (GC) is the fifth most common cancer worldwide. In approximately 10% of GC cases, cancer cells show ubiquitous and monoclonal Epstein-Barr virus (EBV) infection. A significant feature of EBV-associated GC (EBVaGC) is high lym...
Kazuto Harada,Hideo Baba,Jaffer A Ajani
Kazuto Harada
Gastric adenocarcinoma (GAC) is estimated as the fifteenth most common cancer in the USA. Incidence rate has been gradually decreasing, but prognosis remains dismal. For patients with locally advanced GAC (stage > T1B and < T4B), multimodal...
Negative effects of tumor cell nitric oxide on anti-glioblastoma photodynamic therapy [0.03%]
肿瘤细胞一氧化氮对胶质母细胞瘤光动力治疗的负面影响
Albert W Girotti,Jonathan M Fahey,Witold Korytowski
Albert W Girotti
Glioblastomas are highly aggressive brain tumors that can persist after exposure to conventional chemotherapy or radiotherapy. Nitric oxide (NO) produced by inducible NO synthase (iNOS/NOS2) in these tumors is known to foster malignant cell...
Zoya Qureshy,Daniel E Johnson,Jennifer R Grandis
Zoya Qureshy
Aberrant activation of signal transducer and activator of transcription (STAT) proteins is associated with the development and progression of solid tumors. However, as transcription factors, these proteins are difficult to target directly. ...