Hayley M Sabol,Jesus Delgado-Calle
Hayley M Sabol
Multiple myeloma (MM) is a hematologic cancer characterized by uncontrolled growth of malignant plasma cells in the bone marrow and currently is incurable. The bone marrow microenvironment plays a critical role in MM. MM cells reside in spe...
Anna Tessari,Shimaa H A Soliman,Arturo Orlacchio et al.
Anna Tessari et al.
Non-small cell lung cancer (NSCLC) remains the leading cause of cancer-related deaths in the Western world. Despite progress made with targeted therapies and immune checkpoint inhibitors, the vast majority of patients have to undergo chemot...
Diverse roles of bitter melon (Momordica charantia) in prevention of oral cancer [0.03%]
苦瓜(Momordica charantia)在预防口腔癌中的多种作用
Subhayan Sur,Ratna B Ray
Subhayan Sur
Oral squamous cell carcinoma (OSCC) is one of the common lethal malignancies which is increasing rapidly in the world. Increasing risks from alcohol and tobacco habits, lack of early detection markers, lack of effective chemotherapeutic age...
Targeting transcriptional regulators for treatment of anaplastic thyroid cancer [0.03%]
转录调节因子在治疗甲状腺未分化癌中的应用研究
Woo Kyung Lee,Sheue-Yann Cheng
Woo Kyung Lee
Dysregulation of genes perpetuates cancer progression. During carcinogenesis, cancer cells acquire dependency of aberrant transcriptional programs (known as "transcription addiction") to meet the high demands for uncontrolled proliferation....
Giovanna Tosato,Jing-Xin Feng,Hidetaka Ohnuki et al.
Giovanna Tosato et al.
Genetic and epigenetic lesions within hematopoietic cell populations drive diverse hematological malignancies. Myelodysplastic syndromes (MDS) are a group of myeloid neoplasms affecting the hematopoietic stem cells characterized by recurren...
Identification of CYP 2A6 inhibitors in an effort to mitigate the harmful effects of the phytochemical nicotine [0.03%]
鉴定CYP 2A6抑制剂以减轻植物化学物质尼古丁的危害作用
Navneet Goyal,Jayalakshmi Sridhar,Camilla Do et al.
Navneet Goyal et al.
Aim: In this study, our goal was to study the inhibition of nicotine metabolism by P450 2A6, as a means for reduction in tobacco use and consequently the prevention of smoking-related cancers. Nicotine, a phytochemical, i...
Leelamine suppresses cMyc expression in prostate cancer cells in vitro and inhibits prostate carcinogenesis in vivo [0.03%]
Leelamine在体外抑制前列腺癌细胞的cMyc表达并在体内抑制前列腺癌的发生
Krishna B Singh,Eun-Ryeong Hahm,Shivendra V Singh
Krishna B Singh
Aim: Leelamine (LLM) inhibits growth of human prostate cancer cells but the underlying mechanism is not fully understood. The present study was undertaken to determine the effect of LLM on cMyc, which is overexpressed in ...
Nivedita Nag,Samikshan Dutta
Nivedita Nag
Prostate cancer (PCa) is the leading cause of cancer death in men. With more therapeutic modalities available, the overall survival in PCa has increased significantly in recent years. Patients with relapses after advanced secondgeneration a...
Burden of chronic diseases among sarcoma survivors treated with anthracycline chemotherapy: results from an observational study [0.03%]
接受蒽环类药物化疗的肉瘤幸存者中慢性疾病负担的观察性研究结果
Laurence H Baker,Philip S Boonstra,Denise K Reinke et al.
Laurence H Baker et al.
Aim: Cardiovascular disease is a leading cause of mortality among long-term cancer survivors treated with large total doses of doxorubicin. An increase in coronary artery disease (CAD) among childhood cancer survivors by ...