Two rare cancers of the exocrine pancreas: to treat or not to treat like ductal adenocarcinoma? [0.03%]
两种罕见的胰腺外分泌癌：像导管腺癌一样治疗还是不治疗？
Nebojsa Skorupan,Shadin Ghabra,J Alberto Maldonado et al.
Nebojsa Skorupan et al.
Pancreatic cancer is an aggressive malignancy with increasing incidence. Pancreatic ductal adenocarcinoma (PDAC) accounts for > 90% of pancreatic cancer diagnoses, while other exocrine tumors are much rarer. In this review, we have focused ...
Promising therapeutic potential of tumor suppressor microRNAs for malignant pleural mesothelioma [0.03%]
肿瘤抑制微小RNA在恶性胸膜间皮瘤中的治疗潜力
Shivani Dixit,Agnes Y Choi,Anand Singh et al.
Shivani Dixit et al.
Malignant pleural mesothelioma (MPM) is an aggressive and recalcitrant surface neoplasm that defies current multimodality treatments. MicroRNAs (miRNAs) are small noncoding RNAs that epigenetically regulate multiple gene networks and cellul...
Chronic activation of MUC1-C in wound repair promotes progression to cancer stem cells [0.03%]
伤口修复中MUC1-C的慢性活化促进向癌症干细胞进展
Donald W Kufe
Donald W Kufe
The mucin 1 (MUC1) gene emerged in mammals to afford protection of barrier epithelial tissues from the external environment. MUC1 encodes a transmembrane C-terminal (MUC1-C) subunit that is activated by loss of homeostasis and induces infla...
Sridhar Pinnamaneni,Timothy A Damron
Sridhar Pinnamaneni
Proximal humeral reconstructive options following radical resection of proximal humeral primary and metastatic bone malignancies have evolved over time. With the relatively recent advent of the reverse total shoulder (RTSA), this technique ...
Current and emerging therapies for first line treatment of metastatic clear cell renal cell carcinoma [0.03%]
转移性透明细胞肾癌一线治疗的现行和新兴疗法
Michael T Serzan,Michael B Atkins
Michael T Serzan
The therapeutic landscape for advanced clear cell renal cell carcinoma (ccRCC) is rapidly evolving with improved knowledge of the biology of disease leading to the incorporation of a variety of antiangiogenic agents and immunotherapies. In ...
Shashank Kumar,Sanjay Gupta
Shashank Kumar
Epithelial-mesenchymal transition: a hallmark in pancreatic cancer stem cell migration, metastasis formation, and drug resistance [0.03%]
上皮间充质转化：胰腺癌干细胞迁移，转移形成和药物抵抗的标志
Ahmad R Safa
Ahmad R Safa
Metastasis, tumor progression, and chemoresistance are the major causes of death in patients with pancreatic ductal adenocarcinoma (PDAC). Tumor dissemination is associated with the activation of an epithelial-to-mesenchymal transition (EMT...
Letting go of the physical exam: embracing telehealth solutions to oncology [0.03%]
放手体格检查：拥抱肿瘤学的远程医疗解决方案
Michael J Overman
Michael J Overman
Osteolytic effects of tumoral estrogen signaling in an estrogen receptor-positive breast cancer bone metastasis model [0.03%]
在雌激素受体阳性乳腺癌骨转移模型中肿瘤雌激素信号的溶骨作用
Julia N Cheng,Jennifer B Frye,Susan A Whitman et al.
Julia N Cheng et al.
Aim: Estrogen receptor α-positive (ER+) subtypes of breast cancer have the greatest predilection for forming osteolytic bone metastases (BMETs). Because tumor-derived factors mediate osteolysis, a possible role for tumor...
Development of a Functional Assessment of Chronic Illness Therapy item library and primary symptom list for the assessment of patient-reported adverse events associated with immune checkpoint modulators [0.03%]
慢性疾病治疗功能评估项目库及主要症状清单的发展，用于评估与免疫检查点调节剂相关的患者报告不良事件
Kimberly A Webster,Mary L O&#x;Connor,Aaron R Hansen et al.
Kimberly A Webster et al.
Aim: To develop a comprehensive item library of patient-reported, immunotherapy-related adverse events (irAEs) that draws from and expands on the Functional Assessment of Chronic Illness Therapy (FACIT) Measurement System...