Exploring the toxicity mechanisms and detoxification methods of Rhizoma Paridis [0.03%]
重楼毒性的机制及解毒研究进展
Sun Jianwei,Zhang Guowen,Zhang Yan et al.
Sun Jianwei et al.
Although there has been research on the toxicity of Rhizoma Paridis (Chong Lou), a systematic and comprehensive evaluation, as well as targeted strategies for mitigating its toxicity, remains lacking. This review aims to provide a thorough ...
Retraction of "Down-regulation of miR-539 indicates poor prognosis in patients with pancreatic cancer" [0.03%]
撤回：“胰腺癌患者中miR-539表达下调与预后不良相关”
Haibo Yu,Hongliang Song,Zhongwu Ma et al.
Haibo Yu et al.
[This retracts the article DOI: 10.1515/biol-2018-0059.]. © 2025 the author(s), published by De Gruyter.
Lipoxin A4 improves myocardial ischemia/reperfusion injury through the Notch1-Nrf2 signaling pathway [0.03%]
lipoxin a4通过 notch1-nrf2信号通路改善心肌缺血再灌注损伤
Xueyun Yan,Anbang Chen,Yuanqi Gong et al.
Xueyun Yan et al.
This study investigates the mechanism by which lipoxin A4 (LXA4) attenuates myocardial ischemia/reperfusion injury (MIRI). Using a rat MIRI model, we evaluated coronary flow, histopathology, cardiac enzymes (cTnI/CK-MB), oxidative stress ma...
Genetic variants in VWF exon 26 and their implications for type 1 Von Willebrand disease in a Saudi Arabian population [0.03%]
沙特阿拉伯人群中VWF外显子26的基因变异及其对1型血管性血友病的影响
Faisal M Alzahrani,Asma A Al Faris,Layla A Bashawri et al.
Faisal M Alzahrani et al.
Von Willebrand disease (VWD) is one of the most common bleeding disorders, stemming from irregularities in the Von Willebrand factor (VWF). Globally, type 1 VWD (VWD1) is the most prevalent form, characterized by decreased levels of VWF in ...
High levels of EPHB2 expression predict a poor prognosis and promote tumor progression in endometrial cancer [0.03%]
EPHB2高表达预示子宫内膜癌预后不良并促进肿瘤进展
Yanlai Xiao,Jian Wang,Xiangzhai Zhao et al.
Yanlai Xiao et al.
Endometrial cancer (EC) exhibits increasing incidence and mortality, necessitating novel prognostic biomarkers and therapeutic targets. This study systematically investigates EPHB2 as a potential biomarker through comprehensive bioinformati...
Knockdown of SHP-2 delays renal tubular epithelial cell injury in diabetic nephropathy by inhibiting NLRP3 inflammasome-mediated pyroptosis [0.03%]
SHP-2敲低通过抑制NLRP3炎性小体介导的细胞焦亡来延缓糖尿病肾病中的肾小管上皮细胞损伤
Panli Tian,Yanli Ma,Tao Shang
Panli Tian
Src homology phosphotyrosyl phosphatase 2 (SHP-2) has been implicated in the pathogenesis of diabetic nephropathy (DN), while pyroptosis, an inflammatory form of programmed cell death, has also been associated with disease progression. Howe...
Efficacy and mechanism of escin in improving the tissue microenvironment of blood vessel walls via anti-inflammatory and anticoagulant effects: Implications for clinical practice [0.03%]
escapes通过抗炎和抗凝作用改善血管壁组织微环境的有效性和机制：对临床实践的意义
Linyin Yan,Yu Zhang,Yanqiang Li et al.
Linyin Yan et al.
Escin, a natural medicinal saponin, has garnered significant attention in recent years for its pharmacological effects in various diseases. Though the structure and pharmacodynamic targets of escin are documented, reviews on its efficacy an...
Merkel cell carcinoma: Clinicopathological analysis of three patients and literature review [0.03%]
Merkel细胞癌的临床病理分析及文献复习三例
Ting Xu,Xue Meng,Shuai Luo et al.
Ting Xu et al.
To investigate the clinicopathological features of three patients with Merkel cell carcinoma (MCC). The clinicopathological features, immunophenotypes, diagnosis and differential diagnosis, treatment, and prognosis of the three patients wit...
Advances in cancer immunotherapy and future directions in personalized medicine [0.03%]
癌症免疫治疗进展及精准医疗未来方向
Yixuan Wang
Yixuan Wang
Cancer immunotherapy has revolutionized oncologic treatment by harnessing and reprogramming the immune system to target malignant cells. This review provides a comprehensive picture of modern approaches to immunotherapy-based treatment stra...
PSME2 exacerbates ulcerative colitis by disrupting intestinal barrier function and promoting autophagy-dependent inflammation [0.03%]
PSME2通过破坏肠屏障功能并促进自噬依赖性炎症从而加重溃疡性结肠炎
Min Li,Jing Chen,Shimeng Xu et al.
Min Li et al.
The immunoproteasome regulatory component proteasome activator subunit beta (PSME2) plays a crucial role in immune regulation, yet its impact on intestinal barrier integrity in ulcerative colitis (UC) remains unclear. This study aimed to el...