What's new in molecular genetic pathology 2026: emerging biomarkers for personalized cancer therapies [0.03%]
Umberto Maccio
Umberto Maccio
New and emerging biomarkers and current molecular assays for the most prevalent and lethal cancers worldwide-breast, lung, prostate, and colorectal cancer-are described. Notably, HER2-low breast cancer and HER2-mutated non-small cell lung c...
Deep learning-driven immunohistochemical analysis of renal lymphatics for chronic kidney disease: bioinformatic and histopathological study [0.03%]
基于深度学习的肾淋巴管免疫组化分析在慢性肾脏疾病中的应用：生物信息学和病理学研究
Xin Xu,YanPing Lin,Guangchang Pei et al.
Xin Xu et al.
Background: Renal lymphatic vessel density is clinically relevant in kidney disease but is still assessed by slow, subjective visual estimation. We evaluated a weakly supervised, attention-based multiple-instance learning...
Cutaneous soft tissue tumors in the 5th edition of the World Health Organization classification of skin tumors: key updates and new entities [0.03%]
世界卫生组织皮肤肿瘤分类第5版的软组织肿瘤：关键更新和新实体
Joon Hyuk Choi
Joon Hyuk Choi
The 5th edition of the World Health Organization (WHO) classification of skin tumors introduces a dedicated chapter on cutaneous soft tissue tumors, providing a comprehensive, standardized reference with updated diagnostic criteria that dir...
Can micro-CT distinguish between solid lung tumors? A comparative evaluation including solid adenocarcinoma, non-keratinizing squamous cell carcinoma, and carcinoid tumor [0.03%]
微CT能区分实性型肺癌吗？包括肺腺癌、非角化鳞癌和类癌的比较评价
Selim Sevim,Serpil Dizbay Sak,Kaan Orhan et al.
Selim Sevim et al.
Background: Some pulmonary carcinomas display a solid pattern, and immunohistochemistry is commonly used for tumor differentiation. Micro-computed tomography (micro-CT), with its ability to produce detailed three-dimensio...
3-Dimensional reconstruction reveals frequent intraluminal growth of submucosal veins in surgically resected pT1 colorectal cancers [0.03%]
三维重建显示手术切除的pT1期结直肠癌黏膜下静脉向腔内生长很常见
Jihyun Park,Mi-Ju Kim,Yeon Wook Kim et al.
Jihyun Park et al.
Background: Although venous invasion (VI) is associated with distant metastasis and observed in >50% of pT2-4 colorectal cancers (CRCs), the role of VI in pT1 CRCs is not well-defined. ...
Progastrin, annexin A2, and tumor-associated macrophages in gastric adenocarcinoma [0.03%]
胃腺癌中的促胃泌素、肌动蛋白交联因子A2和肿瘤相关巨噬细胞
Konstantinos Christofidis,Rodanthi Fioretzaki,Stylianos Mavropoulos Papoudas et al.
Konstantinos Christofidis et al.
Background: Gastric adenocarcinoma is a major cause of cancer mortality worldwide, and reliable biomarkers remain insufficient. This study investigates the immunohistochemical expression of progastrin (hPG) and annexin A2...
Correlation between HER2 gene copy number and immunohistochemistry categories in HER2-negative breast cancer: diagnostic utility for differentiating HER2-null, ultralow, and low tumors [0.03%]
HER2阴性乳腺癌中HER2基因拷贝数与免疫组化分型的相关性：区分HER2阴性，超低和低HER2肿瘤的诊断价值
Min Chong Kim,Young Kyung Bae
Min Chong Kim
Background: The recent recognition of human epidermal growth factor receptor 2 (HER2)-low and HER2-ultralow breast cancers (BCs) has expanded the therapeutic relevance of HER2 testing in the antibody-drug conjugate era. H...
Prevalence of HER2-ultralow breast cancer in South Korea: a multicenter study by reassessment of HER2-zero cases [0.03%]
韩国HER2超低表达乳腺癌的流行率：通过重新评估HER2阴性病例的多中心研究
Min Chong Kim,Eun Yoon Cho,Hee Jin Lee et al.
Min Chong Kim et al.
Background: This study aimed to determine the prevalence of human epidermal growth factor receptor 2 (HER2)-ultralow breast cancer among cases initially classified as HER2 immunohistochemistry (IHC) 0 and assess interobse...
Multicenter evaluation of the PASS score as a negative predictive tool and the impact of inter-observer variability in pheochromocytoma and paraganglioma risk stratification [0.03%]
PASS评分的多中心评估及其在嗜铬细胞瘤和副神经节瘤风险分层中的阴性预测价值及观察者间差异的影响分析
Sungyeon Jung,Hye-Ri Shin,Su-Jin Shin et al.
Sungyeon Jung et al.
Background: The Pheochromocytoma of the Adrenal Gland Scaled Score (PASS) is widely used for risk stratification in pheochromocytoma and paraganglioma (PPGL), but its clinical utility is limited by inter-observer variabil...
Mutational status of non-invasive follicular thyroid neoplasm with papillary-like nuclear features (NIFTP): molecular analysis should be performed for NIFTPs with nuclear score 3 [0.03%]
非侵袭性乳头状核特征甲状腺滤泡肿瘤(NIFTP)的突变状态:应对核评分为3分的NIFTP进行分子分析
Ayaka Sako,Mitsuyoshi Hirokawa,Michiko Matsuse et al.
Ayaka Sako et al.
Background: The classification of non-invasive follicular thyroid neoplasm with papillary-like nuclear features (NIFTP) was introduced to prevent the overtreatment of indolent tumors that were formerly diagnosed as non-in...