A post hoc analysis of intra-subject coefficients of variation in pharmacokinetic measures to calculate optimal sample sizes for bioequivalence studies [0.03%]
基于药动学指标的组内系数变化的事后分析计算生物等效性研究的最优样本量
Inbum Chung,Jaeseong Oh,SeungHwan Lee et al.
Inbum Chung et al.
Because bioequivalence studies are performed using a crossover design, information on the intra-subject coefficient of variation (intra-CV) for pharmacokinetic measures is needed when determining the sample size. However, calculated intra-C...
Seungil Cho,Young-Ran Yoon
Seungil Cho
This tutorial explains the pharmacokinetics of a prodrug and its active metabolite (or parent drug) using a two-step, consecutive, first-order irreversible reaction as a basic model for prodrug metabolism. In this model, the prodrug is meta...