Determination of donepezil in human plasma using ultra performance liquid chromatography-tandem mass spectrometry [0.03%]
高效液相色谱-串联质谱法测定人血浆中多奈哌齐浓度
Hyeon-Cheol Jeong,Jeong-Eun Park,Ji-Yeon Hyun et al.
Hyeon-Cheol Jeong et al.
An ultra performance liquid chromatography-tandem mass spectrometry (UPLC-MS/MS) method was developed and validated for the quantification of donepezil in human plasma. Donepezil and donepezil-D4 were extracted from human plasma by liquid-l...
Successful additional clarithromycin and tacrolimus treatment for hypereosinophilia associated with eosinophilic granulomatosis with polyangiitis [0.03%]
克拉霉素及他克莫司治疗变应性肉芽肿型血管炎伴嗜酸细胞性胃肠炎的效果良好
Masashi Ohe,Haruki Shida,Tetsuya Horita et al.
Masashi Ohe et al.
A 41-year-old man suffering from eosinophilic granulomatosis with polyangiitis (EPGA), diagnosed at another clinic on the basis of American College of Rheumatology Criteria, with a history of bronchial asthma, eosinophilia, mononeuritis mul...
Pharmacodynamic principles and the time course of delayed and cumulative drug effects [0.03%]
药动学原理及药物延迟效应和累积效应的时间过程
Nick Holford
Nick Holford
This tutorial reviews the principles of the concentration - effect relationship for the usual case when drug effects are delayed relative to changes in circulating concentrations. The key processes determining delay are distribution from th...
Data exclusivity through New Drug Reexamination in Korea: sibutramine hydrochloride (Reductil®) vs. sibutramine mesylate (Slimmer®) as an example [0.03%]
以盐酸西布曲明（ Reduxil?）和甲磺酸西布屈明（ Slimmer?）为例看韩国新药再审查中的数据保护制度
Howard Lee
Howard Lee
The 'equivalent-or-more-but-not-the-same-data' provision in the Regulation on the Safety and Efficacy Evaluation of New Drug in Korea has served as the de facto data exclusivity term for any drug identical to a product subject to new drug r...
Retraction and Republication: A post hoc analysis of intra-subject coefficients of variation in pharmacokinetic measures to calculate optimal sample sizes for bioequivalence studies [0.03%]
撤回与重发：一项事后分析以计算生物等效性研究中药动学指标的最优样本量来计算受试者内变异系数
Inbum Chung,Jaeseong Oh,SeungHwan Lee et al.
Inbum Chung et al.
[This retracts the article on p. 179 in vol. 25.]. Copyright © 2018 Translational and Clinical Pharmacology.
Retraction of Publication
Translational and clinical pharmacology. 2018 Mar;26(1):48. DOI:10.12793/tcp.2018.26.1.48 2018
Comparison of various estimation methods for the parameters of Michaelis-Menten equation based on in vitro elimination kinetic simulation data [0.03%]
基于体外消除动力学模拟数据的米氏方程参数估计方法比较研究
Yong-Soon Cho,Hyeong-Seok Lim
Yong-Soon Cho
The Michaelis-Menten equation is one of the best-known models describing the enzyme kinetics of in vitro drug elimination experiments, and takes a form of equation relating reaction rate (V) to the substrate concentration ([S]) via the maxi...
Quantitative analysis of acetylsalicylic acid in human blood using volumetric absorptive microsampling [0.03%]
定量吸收式微采样在人血清中测定乙酰水杨酸含量
Yunjeong Kim,Ji-Young Jeon,Song-Hee Han et al.
Yunjeong Kim et al.
Volumetric absorptive microsampling (VAMS) is a novel sampling technique that allows for the collection of an accurate volume of blood by dipping a microsampler tip. The purpose of this study is to compare the requirement of a stabilizing r...
Population pharmacokinetic analysis of metformin administered as fixed-dose combination in Korean healthy adults [0.03%]
卡托普利和氢氯噻嗪复方固定剂量制剂在健康受试者中的群体药代动力学研究
Suein Choi,Sangil Jeon,Seunghoon Han
Suein Choi
Metformin, an oral antihyperglycemic agent, is widely used as the first-line pharmacotherapy for type 2 diabetes mellitus (T2DM). It has been in use for several decades as numerous different formulations. However, despite its use, populatio...
Pharmacokinetics of fixed-dose combination of rosuvastatin 20 mg and ezetimibe 10 mg compared to concurrent administration of individual tablets in healthy Korean subjects [0.03%]
在韩国健康志愿者中，瑞舒伐他汀钙片（20毫克）和依折麦布片（10毫克）复方固定剂量制剂与单药联用的药物动力学比较研究
Inyoung Hwang,Sang-In Park,SeungHwan Lee et al.
Inyoung Hwang et al.
This study aimed to compare the pharmacokinetics of fixed-dose combination (FDC) tablet of rosuvastatin 20 mg/ezetimibe 10 mg with that of concurrent administration of individual rosuvastatin 20 mg tablet and ezetimibe 10 mg tablet in healt...
Development of R packages: ' NonCompart' and ' ncar' for noncompartmental analysis (NCA) [0.03%]
用于非 compartment 分析（NCA）的R包“NonCompart”和“ncar”的开发
Hyungsub Kim,Sungpil Han,Yong-Soon Cho et al.
Hyungsub Kim et al.
Noncompartmental analysis (NCA) is a primary analytical approach for pharmacokinetic studies, and its parameters act as decision criteria in bioequivalent studies. Currently, NCA is usually carried out by commercial softwares such as WinNon...