Safety and efficacy of fimasartan with essential hypertension patients in real world clinical practice: data from a post marketing surveillance in Korea [0.03%]
韩国上市后观察研究中安博诺治疗高血压患者的安全性和有效性
Su-Eun Han,Seung Hee Jeong,Hye Jeong Kang et al.
Su-Eun Han et al.
The safety and efficacy of fimasartan have been evaluated through post-marketing surveillance in real world clinical practice. The multi-center, prospective, open-label and non-interventional study. A total of 3,945 patients (3,729 patients...
Mechanistic ligand-receptor interaction model: operational model of agonism [0.03%]
机理配体-受体相互作用模型：激动剂的作用模型
Hyungsub Kim,Hyeong-Seok Lim
Hyungsub Kim
This tutorial explains the basic principles of mechanistic ligand-receptor interaction model, which is an operational model of agonism. A growing number of agonist drugs, especially immune oncology drugs, is currently being developed. In th...
Augmented renal clearance [0.03%]
增强型肾清除率
Arthur J Atkinson Jr
Arthur J Atkinson Jr
Adding to the complexity of caring for critically ill patients is the fact that many of them have a creatinine clearance that exceeds 130 mL/min/1.73 m2. This phenomenon, termed augmented renal clearance (ARC), has only recently been widely...
Jinho Yang,Eun Kyoung Kim,Andrea McDowell et al.
Jinho Yang et al.
The human microbiome is known to play an essential role in influencing host health. Extracellular vesicles (EVs) have also been reported to act on a variety of signaling pathways, distally transport cellular components such as proteins, lip...
Erratum: R-based reproduction of the estimation process hidden behind NONMEM Part 2: First-order conditional estimation [0.03%]
关于基于R重现实数项背后估算过程的更正：第一顺序条件估计部分2
Kyun-Seop Bae,Dong-Seok Yim
Kyun-Seop Bae
[This corrects the article on p. 161 in vol. 24.]. Copyright © 2018 Translational and Clinical Pharmacology.
Published Erratum
Translational and clinical pharmacology. 2018 Jun;26(2):99. DOI:10.12793/tcp.2018.26.2.99 2018
Yun Seob Jung,Dongwoo Chae,Kyungsoo Park
Yun Seob Jung
Cilostazol is used for the treatment of intermittent claudication, ulceration and pain. This study was conducted to develop a population pharmacodynamic (PD) model for cilostazol's closure time (CT) prolongation effect in healthy Korean sub...
The first step to the powers for clinical trials: a survey on the current and future Clinical Trial Management System [0.03%]
临床试验授权的第一步——当前和未来临床试验管理系统调查研究
Jin-Sol Park,Seol Ju Moon,Ji-Hyoung Lee et al.
Jin-Sol Park et al.
A clinical trial management system (CTMS) is a comprehensive program that supports an efficient clinical trial. To improve the environment of clinical trials and to be competitive in the global clinical trials market, an advanced and integr...
Effect of plasma membrane monoamine transporter genetic variants on pharmacokinetics of metformin in humans [0.03%]
人类多巴胺转运蛋白基因变异对二甲双胍药代动力学的影响
Seol Ju Moon,Jaeseong Oh,Seung Hwan Lee et al.
Seol Ju Moon et al.
Metformin, an oral hypoglycemic agent belonging to biguanide class, is widely used to treat type 2 diabetes mellitus, and several drug transporters such as organic cation transporters (OCTs), multidrug and toxin extrusion transporter (MATE)...
Pharmacokinetics comparison of solifenacin tartrate and solifenacin succinate: a randomized, open-label, single-dose, 2-way crossover study in healthy male volunteers [0.03%]
索利那新酒石酸盐与索利那新琥珀酸盐药代动力学对比的随机、开放标记、单剂量、双周期交叉试验（健康男性受试者）
Yu-Mi Kim,Ji-Young Jeon,Seol Ju Moon et al.
Yu-Mi Kim et al.
Solifenacin is a muscarinic antagonist indicated for the treatment of overactive bladder with symptoms. Solifenacin tartrate is a newly developed salt formulation of solifenacin. This study compared the pharmacokinetic and safety properties...