Development of a user-friendly training software for pharmacokinetic concepts and models [0.03%]
一种用户友好的药动学概念和模型培训软件的开发
Seunghoon Han,Byounghee Lim,Hyemi Lee et al.
Seunghoon Han et al.
Although there are many commercially available training software programs for pharmacokinetics, they lack flexibility and convenience. In this study, we develop simulation software to facilitate pharmacokinetics education. General formulas ...
Prediction of the human in vivo antiplatelet effect of S- and R-indobufen using population pharmacodynamic modeling and simulation based on in vitro platelet aggregation test [0.03%]
基于体外血小板聚集试验的人群药动学和模拟预测吲哚布芬(S及R两种异构体)的体内抗血小板效应
Yook-Hwan Noh,Sungpil Han,Sangmin Choe et al.
Yook-Hwan Noh et al.
Indobufen (Ibustrin®), a reversible inhibitor of platelet aggregation, exists in two enantiomeric forms in 1:1 ratio. Here, we characterized the anti-platelet effect of S- and R-indobufen using response surface modeling using NONMEM® and ...
Regulatory innovation for expansion of indications and pediatric drug development [0.03%]
适应症拓展和儿科药物研发的监管创新
Min Soo Park
Min Soo Park
For regulatory approval of a new drug, the most preferred and reliable source of evidence would be randomized controlled trials (RCT). However, a great number of drugs, being developed as well as already marketed and being used, usually lac...
Nick Holford
Nick Holford
This tutorial reviews the principles of dose individualisation with an emphasis on target concentration intervention (TCI). Once a target effect is chosen then pharmacodynamics can predict the target concentration and pharmacokinetics can p...
Five years of the CiPA project (2013-2018): what did we learn? [0.03%]
CiPA项目五年的成果（2013-2018）：我们学到了什么？
Dong-Seok Yim
Dong-Seok Yim
Cases of drug-induced QT prolongation and sudden cardiac deaths resulted in market withdrawal of many drugs and world-wide regulatory changes through accepting the ICH guidelines E14 and S7B. However, because the guidelines were not compreh...
Erratum: Population Pharmacokinetic Analysis of Metformin Administered as Fixed-Dose Combination in Korean Healthy Adults [0.03%]
他莫昔芬与肝癌风险：一项基于人群的队列研究中文标题：甲双胍定剂量复方制剂在韩国健康成人中的群体药代动力学分析勘误通知
Suein Choi,Sangil Jeon,Seunghoon Han et al.
Suein Choi et al.
[This corrects the article on p. 25 in vol. 26.]. Copyright © 2018 Translational and Clinical Pharmacology.
Published Erratum
Translational and clinical pharmacology. 2018 Sep;26(3):143. DOI:10.12793/tcp.2018.26.3.143 2018
Erratum: Comparison of various estimation methods for the parameters of Michaelis-Menten equation based on in vitro elimination kinetic simulation data [0.03%]
Michaelis-Menten方程参数估计方法的比较及其体外消除动力学模拟数据误差修正英文版 corrections
Yong-Soon Cho,Hyeong-Seok Lim
Yong-Soon Cho
[This corrects the article on p. 39 in vol. 26.]. Copyright © 2018 Translational and Clinical Pharmacology.
Published Erratum
Translational and clinical pharmacology. 2018 Sep;26(3):142. DOI:10.12793/tcp.2018.26.3.142 2018
Erratum: Development of R packages: 'NonCompart' and 'ncar' for noncompartmental analysis (NCA) [0.03%]
致读者：非 compart分析的R软件包“noncompart”和“ncar”的开发（非隔室分析(NCA)）
Hyungsub Kim,Sungpil Han,Yong-Soon Cho et al.
Hyungsub Kim et al.
[This corrects the article on p. 10 in vol. 26.]. Copyright © 2018 Translational and Clinical Pharmacology.
Published Erratum
Translational and clinical pharmacology. 2018 Sep;26(3):141. DOI:10.12793/tcp.2018.26.3.141 2018
Development of a UPLC-MS/MS method for the therapeutic monitoring of L-asparaginase [0.03%]
用于L-天冬氨酰胺酶治疗监测的UPLC-MS/MS方法的开发
Hyeon-Cheol Jeong,Therasa Kim,Deok-Hwan Yang et al.
Hyeon-Cheol Jeong et al.
This study aimed to develop a UPLC-MS/MS method for determining plasma levels of L-aspartic acid and L-asparagine and the activity of L-asparaginase. L-aspartic acid, L-asparagine, and L-aspartic acid-2,3,3-d3 were extracted from human plas...
Survey on the undergraduate curriculum in clinical pharmacology and interns' prescribing ability in South Korea [0.03%]
韩国临床药学本科课程和实习医师处方能力调查
Namyi Gu,Kyong-Jee Kim,Chi-Yeon Lim et al.
Namyi Gu et al.
Appropriate prescription writing is one of the critical medical processes affecting the quality of public health care. However, this is a complex task for newly qualified intern doctors because of its complex characteristics requiring suffi...