Seungil Cho,Young-Ran Yoon
Seungil Cho
This tutorial introduces the mathematical skills required to obtain exact and approximate solutions for reversible reactions and provides graphical insights to help understand the pharmacokinetics of reversible metabolism. The matrix method...
Analytical solution of linear multi-compartment models with non-zero initial condition and its implementation with R [0.03%]
非零初值线性多隔室模型的解析解及其R实现方法研究
David Z D&#x;Argenio,Kyun-Seop Bae
David Z D&#x;Argenio
The analytical solution for multi-compartment models with a non-zero initial condition is complex because of the inter-compartmental transfer. An elegant solution and its implementation in the 'wnl' R package can be useful in solving exampl...
Quantification of apixaban in human plasma using ultra performance liquid chromatography coupled with tandem mass spectrometry [0.03%]
基于超高效液相色谱-串联质谱的阿哌沙班药物浓度检测方法
Hyeon-Cheol Jeong,Tae-Eun Kim,Kwang-Hee Shin
Hyeon-Cheol Jeong
Apixaban, an inhibitor of direct factor Xa, is used for the treatment of venous thromboembolic events or prevention of stroke. Unlike many other anticoagulant agents, it does not need periodic monitoring. However, monitoring is still requir...
Characterization of circadian blood pressure patterns using non-linear mixed effects modeling [0.03%]
应用非线性混合效应模型对血压节律的特征分析
Dongwoo Chae,Yukyung Kim,Kyungsoo Park
Dongwoo Chae
Characterizing the time course of baseline or pre-drug blood pressure is important in acquiring unbiased estimates of antihypertensive drug effect. In this study, we recruited 23 healthy male volunteers and measured systolic (SBP) and diast...
Hyeong-Seok Lim
Hyeong-Seok Lim
Pharmacokinetic-pharmacodynamic model is a kind of language that quantitatively describes the drug-related outcomes in the form of mathematical formula. Various outcomes can be subjected to modeling analysis if they can be expressed in numb...
Introduction to in silico model for proarrhythmic risk assessment under the CiPA initiative [0.03%]
CiPA计划下心律失常风险评估的计算机模型概述
Jin-Sol Park,Ji-Young Jeon,Ji-Ho Yang et al.
Jin-Sol Park et al.
In 2005, the International Council for Harmonization (ICH) established cardiotoxicity assessment guidelines to identify the risk of Torsade de Pointes (TdP). It is focused on the blockade of the human ether-à-go-go-related gene (hERG) chan...
Jae-Yong Chung
Jae-Yong Chung
Digital therapeutics (DTx) is a new subsection of digital health that is primarily driven by software and will be of great interest to clinical pharmacologists. In this article, an overview of DTx, including definition, position in the land...
Translational and Clinical Pharmacology: Note from the new Editor-in-Chief [0.03%]
《转化与临床药理学》专栏：新任主编序言
Sang-Goo Shin
Sang-Goo Shin
Ki Young Huh,Jun Gi Hwang,SeungHwan Lee
Ki Young Huh
Mandatory registration of clinical trials in public registry can ensure the transparency of clinical trials. Public clinical trial registry of can provide current chronological and geographical distribution of clinical trial throughout the ...