David J VanderWeele,Baris Turkbey,Adam G Sowalsky
David J VanderWeele
Introduction: The vast majority of men who are diagnosed with prostate cancer die of other causes, highlighting the importance of determining which patient has a risk of death from prostate cancer. Precision management of...
Vishwa Parekh,Michael A Jacobs
Vishwa Parekh
The increasing use of biomarkers in cancer have led to the concept of personalized medicine for patients. Personalized medicine provides better diagnosis and treatment options available to clinicians. Radiological imaging techniques provide...
Hyungsoon Im,Hakho Lee,Cesar M Castro
Hyungsoon Im
Elaine Maggi,Nicole E Patterson,Cristina Montagna
Elaine Maggi
New technologies are rapidly becoming available to expand the arsenal of tools accessible for precision medicine and to support the development of new therapeutics. Advances in liquid biopsies, which analyze cells, DNA, RNA, proteins, or ve...
Efficacy of lumacaftor-ivacaftor for the treatment of cystic fibrosis patients homozygous for the F508del-CFTR mutation [0.03%]
卢卡曲沙-维卡沙治疗CFTR基因F508del纯合突变囊性纤维化患者的效果
Deborah M Cholon,Charles R Esther Jr,Martina Gentzsch
Deborah M Cholon
Cystic fibrosis (CF) results from mutations in the CF transmembrane conductance regulator (CFTR) gene, which codes for the CFTR channel protein. The most common mutation in CF is F508del, which produces a misfolded protein with diminished c...
Rosa S Kim,Nicolas Goossens,Yujin Hoshida
Rosa S Kim
Drug development has been a costly and lengthy process with an extremely low success rate and lack of consideration of individual diversity in drug response and toxicity. Over the past decade, an alternative "big data" approach has been exp...