Epigenetic inhibitors for the precision treatment of ARID1A-mutant ovarian cancers: what are the next steps? [0.03%]
表观遗传学抑制剂在ARID1A突变型卵巢癌的精准治疗中的下一步发展方向？
Takeshi Fukumoto,Rugang Zhang,Benjamin G Bitler
Takeshi Fukumoto
Pharmacogenomic studies of hypertension: paving the way for personalized antihypertensive treatment [0.03%]
高血压的药物基因组学研究：为个性化降压治疗铺平道路
Michael T Eadon,Sri H Kanuri,Arlene B Chapman
Michael T Eadon
Introduction: Increasing clinical evidence supports the implementation of genotyping for anti-hypertensive drug dosing and selection. Despite robust evidence gleaned from clinical trials, the translation of genotype guide...
Sean P Gavan,Alexander J Thompson,Katherine Payne
Sean P Gavan
Introduction: The advancement of precision medicine into routine clinical practice has been highlighted as an agenda for national and international health care policy. A principle barrier to this advancement is in meeting requirements of th...
Recent progress in the use and tracking of transplanted islets as a personalized treatment for type 1 diabetes [0.03%]
用于治疗1型糖尿病移植胰岛的使用和追踪方面的最新研究进展
Genaro A Paredes-Juarez,Paul de Vos,Jeff W M Bulte
Genaro A Paredes-Juarez
Introduction: Type 1 diabetes mellitus (T1DM) is an autoimmune disease in which the pancreas produces insufficient amounts of insulin. T1DM patients require exogenous sources of insulin to maintain euglycemia. Transplanta...
Mohamad M Kronfol,Mikhail G Dozmorov,Rong Huang et al.
Mohamad M Kronfol et al.
Introduction: Epigenetics is the study of reversible modifications to chromatin and their extensive and profound effects on gene regulation. To date, the role of epigenetics in personalized medicine has been under-explore...
Timothy N Clinton,Aditya Bagrodia,Yair Lotan et al.
Timothy N Clinton et al.
Introduction: Prostate cancer is a heterogeneous disease. Existing risk stratification tools based on standard clinlicopathologic variables (prostate specific antigen [PSA], Gleason score, and tumor stage) provide a modes...
Personalized management of asthma exacerbations: lessons from genetic studies [0.03%]
遗传学研究指导下的哮喘急性发作的个体化治疗启示
Alberta L Wang,Kelan G Tantisira
Alberta L Wang
Introduction: The genetics of severe asthma and asthma exacerbations are distinct from milder forms of asthma. Gene-environmental interactions contribute to the complexity and heterogeneity of severe asthma and asthma exa...
Towards precision medicine in Alzheimer's disease: deciphering genetic data to establish informative biomarkers [0.03%]
阿尔茨海默病的精准医疗：解析基因数据以建立具有临床意义的生物标志物
Ornit Chiba-Falek,Michael W Lutz
Ornit Chiba-Falek
Introduction: Developing biomarker tools for identification of individuals at high-risk for late-onset Alzheimer's disease (LOAD) is important for prognosis and early treatment. This review focuses on genetic factors and ...
Genomic-based diagnosis of arrhythmia disease in a personalized medicine era [0.03%]
个性化医疗时代的arrythmia疾病的基因组诊断方法研究
Abdullah Omar,Mi Zhou,Adam Berman et al.
Abdullah Omar et al.
Introduction: Although thousands of potentially disease-causing mutations have been identified in a handful of genes, the genetic heterogeneity has led to diagnostic confusions, stemming directly from the limitations in o...
A review of drugs in development for the personalized treatment of head and neck squamous cell carcinoma [0.03%]
头颈鳞状细胞癌的个体化治疗在研药物进展评审
Andrew C Birkeland,Paul L Swiecicki,J Chad Brenner et al.
Andrew C Birkeland et al.
Introduction: Head and neck squamous cell carcinoma remains a highly morbid and fatal disease, with poor survival rates among patients with advanced and recurrent disease. Recent advances in next generation sequencing, ta...