Nicole Martinez-Martin,David Magnus
Nicole Martinez-Martin
Introduction: Next-generation sequencing (NGS) is expected to revolutionize health care. NGS allows for sequencing of the whole genome more cheaply and quickly than previous techniques. NGS offers opportunities to advance...
Nab-paclitaxel and atezolizumab for the treatment of PD-L1-positive, metastatic triple-negative breast cancer: review and future directions [0.03%]
纳武-紫杉烷和阿特朱单抗治疗PD-L1阳性转移性三阴性乳腺癌：综述与未来发展方向
Jodi A Kagihara,Michelle Andress,Jennifer R Diamond
Jodi A Kagihara
Introduction: Breast cancer is the most common malignancy in women in the United States and triple-negative breast cancer (TNBC) accounts for 15-20%. The standard of care for metastatic TNBC has been limited to cytotoxic ...
Immunotherapy and next-generation sequencing guided therapy for precision oncology: What have we learnt and what does the future hold? [0.03%]
免疫治疗和下一代测序引导的精准肿瘤学治疗：我们学到了什么？未来将去向何方？
Roman Groisberg,Vivek Subbiah
Roman Groisberg
Introduction: The rapid development of clinical next generation sequencing (NGS) and the contemporaneous availability of molecular targeted therapies ignited and fueled the field of precision oncology. More recently there...
Susanne B Haga
Susanne B Haga
Introduction: Pharmacogenetic (PGx) testing has greatly expanded due to enhanced understanding of the role of genes in drug response and advances in DNA-based testing technology development. As many primary care visits re...
The genetic risk of second cancers: should the therapy for acute lymphoblastic leukemia be individualized according to germline genetic makeup? [0.03%]
遗传性二次肿瘤风险：急淋治疗应考虑遗传背景吗？
Kathleen E A Felton,Christopher C Porter,Jun J Yang
Kathleen E A Felton
Manuel Sânchez-de-la-Torre,David Gozal
Manuel Sânchez-de-la-Torre
Introduction: Obstructive sleep apnea (OSA) is a highly prevalent condition that is viewed as a major global health concern, while affecting approximately 10% of the middle-aged population. OSA is a chronic disease that h...
Tongqi Qian,Shijia Zhu,Yujin Hoshida
Tongqi Qian
Introduction: Big-data-driven drug development resources and methodologies have been evolving with ever-expanding data from large-scale biological experiments, clinical trials, and medical records from participants in dat...
Vishwa S Parekh,Michael A Jacobs
Vishwa S Parekh
Introduction: The radiological reading room is undergoing a paradigm shift to a symbiosis of computer science and radiology using artificial intelligence integrated with machine and deep learning with radiomics to better ...
Marie D Ralff,Wafik S El-Deiry
Marie D Ralff
Introduction: Despite decades of focused research efforts, cancer remains a significant cause of morbidity and mortality. Tumor necrosis factor(TNF)-related apoptosis-inducing ligand (TRAIL) is capable of inducing cell de...