GUCY2C as a biomarker to target precision therapies for patients with colorectal cancer [0.03%]
GUCY2C作为结直肠癌精确诊疗的生物标志物及其靶向免疫治疗研究
Amanda N Lisby,John C Flickinger Jr,Babar Bashir et al.
Amanda N Lisby et al.
Introduction: Colorectal cancer (CRC) is one of the most-deadly malignancies worldwide. Current therapeutic regimens for CRC patients are relatively generic, based primarily on disease type and stage, with little variatio...
David A Hormuth nd,Angela M Jarrett,Guillermo Lorenzo et al.
David A Hormuth nd et al.
The evolution of patient-specific precision biomarkers to guide personalized heart-transplant care [0.03%]
个性化心脏移植治疗的精准个体化生物标志物的发展历程
Mario C Deng
Mario C Deng
Introduction: In parallel to the clinical maturation of heart transplantation over the last 50 years, rejection testing has been revolutionized within the systems biology paradigm triggered by the Human Genome Project. ...
Michael H Roehrl,Victor B Roehrl,Julia Y Wang
Michael H Roehrl
Roles of CRAC channel in cancer: implications for therapeutic development [0.03%]
CRAC通道在癌症中的作用：治疗开发的启示
Husain Yar Khan,Iqra Mazahir,Shriya Reddy et al.
Husain Yar Khan et al.
Introduction: The Ca2+release-activated Ca2+ (CRAC) channel, composed of Orai and STIM proteins, represents one of the main routes of Ca2+ entry in most non-excitable cells. There is accumulating evidence to suggest that ...
Sickle cell disease in the era of precision medicine: looking to the future [0.03%]
精准医学时代的镰状细胞疾病：展望未来
Martin H Steinberg,Sara Kumar,George J Murphy et al.
Martin H Steinberg et al.
Introduction: Sickle cell anemia is a mendelian disease that is noted for the heterogeneity of its clinical expression. Because of this, providing an accurate prognosis has been a longtime quest. ...
Ellen Zhang,Albert M Levin,L Keoki Williams
Ellen Zhang
Introduction: Asthma is a common condition that affects large numbers of children and adults, yet the burden of disease is not equally distributed amongst groups. In the United States, African Americans and Puerto Ricans ...
Theresa L Whiteside
Theresa L Whiteside
Introduction: Regulatory T cells (Treg) and their role in health and disease is being intensively investigated. Today, human Treg emerge as a highly heterogeneous subset of CD4+ T cells which mediate immune suppression bu...