Engineered microvascular basement membrane mimetic for real-time neutrophil tracking in the microvascular wall [0.03%]
仿生微血管基底膜用于实时监测中性粒细胞在活体微血管壁内的运动行为
Laura C Morales,Catherine D Kim,Yangang Pan et al.
Laura C Morales et al.
The microvascular basement membrane (mvBM) is crucial in maintaining vascular integrity and function and, therefore, key to the health of major organs. However, the complex nature and the intricate interplay of biochemical and biomechanical...
Bisulfite-free PCDHGB7 methylation in urine enables early noninvasive detection of urothelial carcinoma [0.03%]
无硫酸盐处理的尿液PCDHGB7甲基化检测用于早期非侵入性膀胱癌诊断
Zhicong Yang,Qing Chen,Shihua Dong et al.
Zhicong Yang et al.
Urothelial carcinomas (UCs) are the fourth most common male malignancies. However, currently implemented detection methods for UC are usually invasive and/or show passable sensitivity and specificity. An accurate, practical, and effective a...
Carboxymethyl cellulose-polylactic acid particles for inhibiting anoikis and enhancing wound healing efficacy of human mesenchymal stem cells [0.03%]
用于抑制悬浮诱导的细胞凋亡并增强人間質幹細胞促伤口癒合功效的羧甲基纖維素-聚乳酸微球
Dong-Hyun Lee,You Bin Lee,Hyun Su Park et al.
Dong-Hyun Lee et al.
Adult human mesenchymal stem cells (hMSCs) injection into the wound site promotes angiogenesis and the wound-closing process by secreting various growth and immune-modulating factors. However, lower cell attachment sites and the hypoxic mic...
Machine learning-assisted point-of-care diagnostics for cardiovascular healthcare [0.03%]
基于机器学习的心血管疾病床旁检测技术
Kaidong Wang,Bing Tan,Xinfei Wang et al.
Kaidong Wang et al.
Cardiovascular diseases (CVDs) continue to drive global mortality rates, underscoring an urgent need for advancements in healthcare solutions. The development of point-of-care (POC) devices that provide rapid diagnostic services near patien...
Early nanoparticle intervention preserves motor function following cervical spinal cord injury [0.03%]
纳米粒子早期介入可保护颈椎损伤后的运动功能
Sarah E Hocevar,Brian C Ross,Yinghao Wang et al.
Sarah E Hocevar et al.
Spinal cord injury (SCI) triggers an immediate influx of immune cells that secrete pro-inflammatory cytokines and reactive oxygen species that cause tissue damage that is secondary to the initial physical trauma. We aim to reprogram these i...
In vivo evaluation of decellularized skeletal muscle matrices for skeletal muscle repair: A systematic review [0.03%]
脱细胞骨骼肌基质在骨骼肌修复中的应用：系统性综述
Ina Hennion,Charlot Philips,Chong Jiang et al.
Ina Hennion et al.
Volumetric muscle loss is the significant loss of skeletal muscle volume beyond the innate regenerative capacity, resulting in functional impairment. The current standard of care combines muscle autografting with physical therapy but is oft...
Biomembrane-coated nanosystems as next-generation delivery systems for the treatment of gastrointestinal cancers [0.03%]
用于治疗胃肠道癌症的生物膜包覆型纳米系统作为下一代递送系统
Joana Lopes,Daniela Lopes,Mahzad Motallebi et al.
Joana Lopes et al.
Gastrointestinal cancers, a major global cause of cancer-related mortality and disease burden, are a heterogeneous group of malignant aliments involving different organs of the digestive system. The late clinical diagnosis, genomic tumor he...
Micrometer-scale tPA beads amplify plasmin generation for enhanced thrombolytic therapy [0.03%]
微米级tPA珠放大纤溶蛋白原生成用于增强溶栓疗法
Matthew J Osmond,Fabrice Dabertrand,Nidia Quillinan et al.
Matthew J Osmond et al.
Rapid restoration of blood flow is critical in treating acute ischemic stroke. Current thrombolytic therapies using tissue plasminogen activator (tPA) are limited by low recanalization rates and risks of off-target bleeding. Here, we demons...
Noninvasive monitoring of vascular alterations in mice with acute lower limb ischemia using multimodal photoacoustic imaging [0.03%]
利用多模态光声成像监测急性下肢缺血小鼠的血管变化
Heng Wang,Keyi Fan,Yijie Ning et al.
Heng Wang et al.
Acute limb ischemia (ALI), especially acute lower limb ischemia (ALLI), is a common clinical vascular emergency with high amputation and mortality rates. However, major challenges exist in rapidly diagnosing and assessing collateral vascula...
Synergistic drug combination screening using a nanodroplet processing platform to enhance neuroblastoma treatment in TH-MYCN transgenic mice [0.03%]
一种用于筛选药物组合以增强神经母细胞瘤小鼠治疗的纳升级处理平台
Yen-Tzu Liao,Zhi-Kai Yu,Yi-Xun Huang et al.
Yen-Tzu Liao et al.
Neuroblastoma is a highly aggressive pediatric cancer with a poor prognosis, particularly in high-risk (HR) cases characterized by MYCN amplification. The severe side effects associated with high-dose chemotherapy further complicate treatme...