Reducing neuroinflammation by delivery of IL-10 encoding lentivirus from multiple-channel bridges [0.03%]
通过多通道桥递送编码IL-10的 lentivirus 减少神经炎症
Daniel J Margul,Jonghyuck Park,Ryan M Boehler et al.
Daniel J Margul et al.
The spinal cord is unable to regenerate after injury largely due to growth-inhibition by an inflammatory response to the injury that fails to resolve, resulting in secondary damage and cell death. An approach that prevents inhibition by att...
High-throughput screening of clinically approved drugs that prime polyethylenimine transfection reveals modulation of mitochondria dysfunction response improves gene transfer efficiencies [0.03%]
高通量筛选临床批准药物促进聚乙烯亚胺转染的prime作用并揭示调节线粒体功能障碍反应可提高基因转移效率
Albert Nguyen,Jared Beyersdorf,Jean-Jack Riethoven et al.
Albert Nguyen et al.
Nonviral gene delivery methods are advantageous over viral vectors in terms of safety, cost, and flexibility in design and application, but suffer from lower gene transfer efficiency. In addition to modifications to nucleic acid design and ...
Immunotherapy against glioblastoma using backpack-activated neutrophils [0.03%]
使用背包激活的中性粒细胞针对胶质母细胞瘤的免疫疗法
Immune checkpoint inhibitors (ICIs) represent new therapeutic candidates against glioblastoma multiforme (GBM); however, their efficacy is clinically limited due to both local and systemic immunosuppressive environments. Hence, therapeutic ...
Key parameters for designing robust 2D and 3D spheroid models for in vitro atherosclerosis research [0.03%]
体外动脉粥样硬化研究的二维和三维球体模型设计的关键参数
Atherosclerosis is a chronic, systemic, inflammatory disease associated with the build-up of fatty deposits ("plaques") in the arteries. A major global health burden, severe atherosclerosis progresses to ischemic heart disease, an underlyin...
Nanoparticle contrast-enhanced computed tomography and magnetic resonance imaging of vascularization of a subcutaneous niche for islet transplantation [0.03%]
纳米颗粒增强的CT和MR血管成像评估皮下移植龛组织中的新生血管形成
Revascularization plays a critical role in the successful engraftment of transplanted pancreatic islets, which are inherently rich in capillaries to meet their high metabolic demands. Innovative islet encapsulation strategies such as the NI...