Jicheng Yu,Yuqi Zhang,Hunter Bomba et al.
Jicheng Yu et al.
Diabetic therapeutics, including insulin and glucagon-like peptide 1 (GLP-1), are essential for diabetic patients to regulate blood glucose levels. However, conventional treatments that are based on subcutaneous injections are often associa...
Yi Li,Feihu Wang,Honggang Cui
Yi Li
The demand for therapeutic biologics has rapidly grown over recent decades, creating a dramatic shift in the pharmaceutical industry from small molecule drugs to biological macromolecular therapeutics. As a result of their large size and in...
Reduced arterial elasticity due to surgical skeletonization is ameliorated by abluminal PEG hydrogel [0.03%]
外渗Peg水凝胶可改善手术剥离所致动脉弹性降低现象
Karyn G Robinson,Rebecca A Scott,Anne M Hesek et al.
Karyn G Robinson et al.
Arteries for bypass grafting are harvested either with neighboring tissue attached or as skeletonized vessels that are free of surrounding tissue. There are significant benefits to skeletonization, but reports suggest that skeletonized vess...
IgA and IgM protein primarily drive plasma corona-induced adhesion reduction of PLGA nanoparticles in human blood flow [0.03%]
IgA和IgM蛋白主要驱动PLGA纳米颗粒在人体血液流动中通过血浆晕轮作用降低粘附性
Daniel J Sobczynski,Omolola Eniola-Adefeso
Daniel J Sobczynski
The high abundance of immunoglobulins (Igs) in the plasma protein corona on poly(lactic-co-glycolic) acid (PLGA)-based vascular-targeted carriers (VTCs) has previously been shown to reduce their adhesion to activated endothelial cells (aECs...
Impact of cell culture parameters on production and vascularization bioactivity of mesenchymal stem cell-derived extracellular vesicles [0.03%]
细胞培养参数对间充质干细胞源外泌体生成及促血管化活性的影响
Divya B Patel,Kelsey M Gray,Yasasvhinie Santharam et al.
Divya B Patel et al.
Mesenchymal stem cell (MSC)-derived extracellular vesicles (EVs) have emerged as potential therapeutic agents for numerous applications. EVs offer potential advantages over cell-based therapies with regard to safety, stability and clearance...
Designing biomaterials with immunomodulatory properties for tissue engineering and regenerative medicine [0.03%]
用于组织工程和再生医学的具有免疫调节性能的生物材料的设计
James I Andorko,Christopher M Jewell
James I Andorko
Recent research in the vaccine and immunotherapy fields has revealed that biomaterials have the ability to activate immune pathways, even in the absence of other immune-stimulating signals. Intriguingly, new studies reveal these responses a...
ICAM-1-Targeted Nanocarriers Attenuate Endothelial Release of Soluble ICAM-1, an Inflammatory Regulator [0.03%]
ICAM-1靶向的纳米载体可降低内皮细胞释放可溶性ICAM-1（一种炎症调节因子）的作用
Rachel L Manthe,Silvia Muro
Rachel L Manthe
Targeting of drug nanocarriers (NCs) to intercellular adhesion molecule-1 (ICAM-1), an endothelial-surface protein overexpressed in many pathologies, has shown promise for therapeutic delivery into and across this lining. Yet, due to the ro...
Synthetic nanoscale electrostatic particles as growth factor carriers for cartilage repair [0.03%]
合成纳米静电颗粒作为生长因子载体用于软骨修复
Nisarg J Shah,Brett C Geiger,Mohiuddin A Quadir et al.
Nisarg J Shah et al.
The efficient transport of biological therapeutic materials to target tissues within the body is critical to their efficacy. In cartilage tissue, the lack of blood vessels prevents the entry of systemically administered drugs at therapeutic...
Specific targeting of the deubiquitinase and E3 ligase families with engineered ubiquitin variants [0.03%]
利用工程化泛素变异体对去泛素酶和E3连接酶家族进行特异性靶向
Maryna Gorelik,Sachdev S Sidhu
Maryna Gorelik
The ubiquitin proteasome system (UPS) has garnered much attention due to its potential for the development of therapeutics. Following a successful clinical application of general proteasome inhibitors much effort has been devoted to targeti...
Sahil Inamdar,Rajeshwar Nitiyanandan,Kaushal Rege
Sahil Inamdar
Exosomes are nanoscale extracellular vesicles that are shed from different cells in the body. Exosomes encapsulate several biomolecules including lipids, proteins, and nucleic acids, and can therefore play a key role in cellular communicati...