Oral tissue spheroid, organoid, and organ-on chip microphysiological modeling strategies towards enhanced emulation of health and disease [0.03%]
口腔组织球体、类器官和芯片器官生理模型策略，以增强健康和疾病模拟能力
Z Gouveia,A Özkan,W V Giannobile et al.
Z Gouveia et al.
Diseases and disorders of dental, oral, and craniofacial (DOC) tissues represent a significant global health burden and have been found to have the greatest age-standardized prevalence and incidence of all reported diseases worldwide. While...
Transport physics-informed reinforcement learning agents deployed in standalone infusion pumps for managing multidrug delivery in critical care [0.03%]
基于输运物理信息的优势学习代理在独立式输液泵中的应用以管理重症监护中的多种药物输送
V Chandran Suja,A L H S Detry,N M Sims et al.
V Chandran Suja et al.
Managing delivery of complex multidrug infusions in anesthesia and critical care presents a significant clinical challenge. Current practices relying on manual control of infusion pumps often result in unpredictable drug delivery profiles a...
Spatial-hindrance-based pro-Adalimumab prevents anti-idiotypic antibody interference in pharmacokinetic and therapeutic efficacy [0.03%]
基于空间障碍的助Adalimumab可防止抗独特型抗体对药代动力学和治疗效果的影响
Bo-Cheng Huang,Yu-Tung Chen,Yun-Chi Lu et al.
Bo-Cheng Huang et al.
Adalimumab (Humira) represents a major advance in rheumatoid arthritis (RA) therapy. However, with long-term administration of Adalimumab, anti-idiotypic antibody (anti-Id Ab) accelerates the Adalimumab clearance rate and reduces the therap...
USENSE: A proof-of-concept self-screening tool for home-based recurrent urinary tract infection management [0.03%]
USENSE：一种家庭复发性尿路感染管理的自我筛查工具的概念验证工具
Antra Ganguly,Ujjaini Basu,Varun Gunda et al.
Antra Ganguly et al.
In this work, we report a novel proof-of-concept biosensing diagnostic tool for the multiplexed electrochemical quantitation of a unique combination of three UTI-relevant biomarkers, Prostaglandin E2 (PGE2), Interleukin-8 (IL-8), and Lipopo...
Machine learning-based SERS serum detection platform for high-sensitive and high-throughput diagnosis of colorectal precancerous lesions [0.03%]
基于机器学习的SERS血清检测平台用于结直肠癌前病变的高灵敏高通量诊断
Qunshan Zhu,Gaoyang Chen,Lei Fu et al.
Qunshan Zhu et al.
Colorectal precancerous lesions (CRP) are early signs of cancer development, and early detection helps prevent progression to colorectal cancer (CRC), reducing incidence and mortality rates. This study developed a serum detection platform i...
Capture of Group A Streptococcus by open-microfluidic CandyCollect device in pediatric patients [0.03%]
一种开放式微流控装置CandyCollect用于儿童患者A群链球菌的检测
Wan-Chen Tu,Ingrid H Robertson,Andrea Blom et al.
Wan-Chen Tu et al.
State the purpose: Obtaining high-quality samples to diagnose streptococcal pharyngitis in pediatric patients is challenging due to discomfort associated with traditional pharyngeal swabs. This may cause reluctance to go ...
Multiaxial rotational loading compromises the transition zone of the intervertebral disc: Ex vivo study using next-generation bioreactors [0.03%]
多轴旋转加载损害椎间盘过渡区：使用新一代生物反应器的离体研究
Amra Šećerović,Aapo Ristaniemi,Francesco Crivelli et al.
Amra Šećerović et al.
Bioreactors have become indispensable tools in spine research, enabling long-term intervertebral disc culture under controlled biological and mechanical conditions. Conventional systems are often limited to uniaxial loading, restricting the...
Optimizing design parameters of 3D-printed poly-4-hydroxybutyrate nipple scaffolds for nipple reconstruction [0.03%]
优化用于乳头再造的3D打印聚4-羟基丁酸酯乳头支架的设计参数
Xue Dong,Sophia Salingaros,Timothy Butler et al.
Xue Dong et al.
Nipple reconstruction in patients who undergo total mastectomy or nipple-sparing mastectomy is currently limited by a consistent and significant loss of nipple projection over time, which can negatively affect patient satisfaction and quali...
Optogenetic modulation of peripheral nociceptive neurons with biocompatible optoelectronic implants [0.03%]
具有生物相容性光电子植入体的外周痛觉神经元的光遗传学调节
Paul Chu Sin Chung,Valentina Paggi,Marie Pertin et al.
Paul Chu Sin Chung et al.
Hyperexcitability of peripheral sensory neurons plays a critical role in the development and maintenance of chronic pain. Pharmacological analgesics used in clinics reduce neuronal activity. They often come with non-negligible side effects....
Dissecting contributions of pulmonary arterial remodeling to right ventricular afterload in pulmonary hypertension [0.03%]
肺动脉重塑在肺动脉高压右心后负荷中的作用机制研究
Sunder Neelakantan,Emilio A Mendiola,Byron Zambrano et al.
Sunder Neelakantan et al.
Pulmonary hypertension (PH) is defined as an elevation in the right ventricular (RV) afterload, characterized by increased hemodynamic pressure in the main pulmonary artery (PA). Elevations in RV afterload increase RV wall stress, resulting...