Evaluation of Receptor-Ligand Mechanisms of Dual-Targeted Particles to an Inflamed Endothelium [0.03%]
评估双重靶向颗粒针对炎症内皮的受体-配体机制
Catherine A Fromen,Margaret B Fish,Anthony Zimmerman et al.
Catherine A Fromen et al.
Vascular-targeted carriers (VTCs) are designed as leukocyte mimics, decorated with ligands that target leukocyte adhesion molecules (LAMs) and facilitate adhesion to diseased endothelium. VTCs require different design considerations than ot...
Integration of growth factor gene delivery with collagen-triggered wound repair cascades using collagen-mimetic peptides [0.03%]
利用类胶原多肽整合生长因子基因传递与胶原触发的伤口愈合级联反应
Morgan A Urello,Kristi L Kiick,Millicent O Sullivan
Morgan A Urello
Growth factors (GFs) play vital roles in wound repair. Many GF therapies have reached clinical trials, but success has been hindered by safety concerns and a lack of efficacy. Previously, we presented an approach to produce protein factors ...
Evaluating side effects of nanoparticle-mediated siRNA delivery to mesenchymal stem cells using next generation sequencing and enrichment analysis [0.03%]
基于下一代测序和富集分析评估纳米颗粒介导的siRNA向间充质干细胞递送的副作用
Dominic W Malcolm,Janet E Sorrells,Daniel Van Twisk et al.
Dominic W Malcolm et al.
RNA interference has immense potential to modulate cell functions. However, effective delivery of small interfering RNA (siRNA) while avoiding deleterious side effects has proven challenging. This study investigates both intended and uninte...
Controlling the surface-mediated release of DNA using 'mixed multilayers' [0.03%]
利用混合多层结构控制DNA的表面介导释放现象
Visham Appadoo,Matthew C D Carter,David M Lynn
Visham Appadoo
We report the design of erodible 'mixed multilayer' coatings fabricated using plasmid DNA and combinations of both hydrolytically degradable and charge-shifting cationic polymer building blocks. Films fabricated layer-by-layer using combina...
Reducing neuroinflammation by delivery of IL-10 encoding lentivirus from multiple-channel bridges [0.03%]
通过多通道桥递送编码IL-10的 lentivirus 减少神经炎症
Daniel J Margul,Jonghyuck Park,Ryan M Boehler et al.
Daniel J Margul et al.
The spinal cord is unable to regenerate after injury largely due to growth-inhibition by an inflammatory response to the injury that fails to resolve, resulting in secondary damage and cell death. An approach that prevents inhibition by att...
High-throughput screening of clinically approved drugs that prime polyethylenimine transfection reveals modulation of mitochondria dysfunction response improves gene transfer efficiencies [0.03%]
高通量筛选临床批准药物促进聚乙烯亚胺转染的prime作用并揭示调节线粒体功能障碍反应可提高基因转移效率
Albert Nguyen,Jared Beyersdorf,Jean-Jack Riethoven et al.
Albert Nguyen et al.
Nonviral gene delivery methods are advantageous over viral vectors in terms of safety, cost, and flexibility in design and application, but suffer from lower gene transfer efficiency. In addition to modifications to nucleic acid design and ...
Immunotherapy against glioblastoma using backpack-activated neutrophils [0.03%]
使用背包激活的中性粒细胞针对胶质母细胞瘤的免疫疗法
Immune checkpoint inhibitors (ICIs) represent new therapeutic candidates against glioblastoma multiforme (GBM); however, their efficacy is clinically limited due to both local and systemic immunosuppressive environments. Hence, therapeutic ...
Key parameters for designing robust 2D and 3D spheroid models for in vitro atherosclerosis research [0.03%]
体外动脉粥样硬化研究的二维和三维球体模型设计的关键参数
Atherosclerosis is a chronic, systemic, inflammatory disease associated with the build-up of fatty deposits ("plaques") in the arteries. A major global health burden, severe atherosclerosis progresses to ischemic heart disease, an underlyin...
Nanoparticle contrast-enhanced computed tomography and magnetic resonance imaging of vascularization of a subcutaneous niche for islet transplantation [0.03%]
纳米颗粒增强的CT和MR血管成像评估皮下移植龛组织中的新生血管形成
Revascularization plays a critical role in the successful engraftment of transplanted pancreatic islets, which are inherently rich in capillaries to meet their high metabolic demands. Innovative islet encapsulation strategies such as the NI...