Self-healing encapsulation and controlled release of vaccine antigens from PLGA microparticles delivered by microneedle patches [0.03%]
自愈型封装及微针贴片递送PLGA微粒中疫苗抗原的控制释放
J Maxwell Mazzara,Lukasz J Ochyl,Justin K Y Hong et al.
J Maxwell Mazzara et al.
There is an urgent need to reduce reliance on hypodermic injections for many vaccines to increase vaccination safety and coverage. Alternative approaches include controlled release formulations, which reduce dosing frequencies, and utilizin...
Gelatin-polysaccharide composite scaffolds for 3D cell culture and tissue engineering: Towards natural therapeutics [0.03%]
用于三维细胞培养和组织工程的明胶多糖复合支架：迈向天然疗法
Samson Afewerki,Amir Sheikhi,Soundarapandian Kannan et al.
Samson Afewerki et al.
Gelatin is a promising material as scaffold with therapeutic and regenerative characteristics due to its chemical similarities to the extracellular matrix (ECM) in the native tissues, biocompatibility, biodegradability, low antigenicity, co...
Applications of decellularized extracellular matrix in bone and cartilage tissue engineering [0.03%]
脱细胞基质在骨和软骨组织工程中的应用研究进展
Yu Seon Kim,Marjan Majid,Anthony J Melchiorri et al.
Yu Seon Kim et al.
Regenerative therapies for bone and cartilage injuries are currently unable to replicate the complex microenvironment of native tissue. There are many tissue engineering approaches attempting to address this issue through the use of synthet...
Lipid nanoparticles silence tumor necrosis factor α to improve wound healing in diabetic mice [0.03%]
脂质纳米颗粒通过沉默肿瘤坏死因子α来改善糖尿病小鼠的伤口愈合
Lisa N Kasiewicz,Kathryn A Whitehead
Lisa N Kasiewicz
Diabetes mellitus is a mounting concern in the United States, as are the mortality and morbidity that result from its complications. Of particular concern, diabetes patients frequently suffer from impaired wound healing and resultant nonhea...
Multivariate learning framework for long-term adaptation in the artificial pancreas [0.03%]
人工胰腺长期适应的多变量学习框架
Dawei Shi,Eyal Dassau,Francis J Doyle rd
Dawei Shi
The long-term use of the artificial pancreas (AP) requires an automated insulin delivery algorithm that can learn and adapt with the growth, development, and lifestyle changes of patients. In this work, we introduce a data-driven AP adaptat...
Rescuing mesenchymal stem cell regenerative properties on hydrogel substrates post serial expansion [0.03%]
体外传代扩增后间充质干细胞在水凝胶底物上成瘤性及组织修复潜能的评估与恢复研究
Varsha V Rao,Michael K Vu,Hao Ma et al.
Varsha V Rao et al.
The use of human mesenchymal stem/stromal cells (hMSCs) in most clinical trials requires millions of cells/kg, necessitating ex vivo expansion typically on stiff substrates (tissue culture polystyrene [TCPS]), which induces osteogenesis and...
Engineering, on-demand manufacturing, and scaling-up of polymeric nanocapsules [0.03%]
工程，按需制造和缩放聚合物纳米胶囊
José Crecente-Campo,María José Alonso
José Crecente-Campo
Polymeric nanocapsules are versatile delivery systems with the capacity to load lipophilic drugs in their oily nucleus and hydrophilic drugs in their polymeric shell. The objective of this work was to expand the technological possibilities ...
Method of establishing breast cancer brain metastases affects brain uptake and efficacy of targeted, therapeutic nanoparticles [0.03%]
建立乳腺癌脑转移的方法影响了靶向治疗纳米粒子的脑摄取和疗效
Emily A Wyatt,Mark E Davis
Emily A Wyatt
HER2-targeted therapies effectively control systemic disease, but their efficacy against brain metastases is hindered by their low penetration of the blood-brain and blood-tumor barriers (BBB and BTB). We investigate brain uptake and antitu...
Uptake and function of membrane-destabilizing cationic nanogels for intracellular drug delivery [0.03%]
用于细胞内药物递送的破坏膜稳定性的阳离子纳米凝胶的吸收和功能
William B Liechty,Rebekah L Scheuerle,Julia E Vela Ramirez et al.
William B Liechty et al.
The design of intracellular drug delivery vehicles demands an in-depth understanding of their internalization and function upon entering the cell to tailor the physicochemical characteristics of these platforms and achieve efficacious treat...
Maria Jarvis,Vinu Krishnan,Samir Mitragotri
Maria Jarvis
Poorly soluble small molecules typically pose translational hurdles owing to their low solubility, low bioavailability, and formulation challenges. Nanocrystallization is a versatile method for salvaging poorly soluble drugs with the added ...