Layer-by-layer nanoparticles for novel delivery of cisplatin and PARP inhibitors for platinum-based drug resistance therapy in ovarian cancer [0.03%]
分层纳米颗粒用于顺铂和PARP抑制剂的新型递送以治疗卵巢癌中的基于铂药物抗性疗法
Lawrence B Mensah,Stephen W Morton,Jiahe Li et al.
Lawrence B Mensah et al.
Advanced staged high-grade serous ovarian cancer (HGSOC) is the leading cause of gynecological cancer death in the developed world, with 5-year survival rates of only 25-30% due to late-stage diagnosis and the shortcomings of platinum-based...
Yaqi Lyu,Qingqing Xiao,Yi Li et al.
Yaqi Lyu et al.
The treatment of metastatic cancer is a great challenging issue throughout the world. Conventional chemotherapy can kill the cancer cells and, whereas, would exacerbate the metastasis and induce drug resistance. Here, a new combinatorial tr...
Role of synergy and immunostimulation in design of chemotherapy combinations: An analysis of doxorubicin and camptothecin [0.03%]
协同作用和免疫刺激在化疗药物组合设计中的作用：多柔比星和喜树碱联合用药分析
Anusha Pusuluri,Vinu Krishnan,Debra Wu et al.
Anusha Pusuluri et al.
Combination chemotherapy is often employed to improve therapeutic efficacies of drugs. However, traditional combination regimens often utilize drugs at or near-their maximum tolerated doses (MTDs), elevating the risk of dose-related toxicit...
Long-term therapeutic effect in nonhuman primate eye from a single injection of anti-VEGF controlled release hydrogel [0.03%]
长效抗VEGF药物控制释放凝胶的治疗效果研究
Yu Yu,Xingyan Lin,Qilin Wang et al.
Yu Yu et al.
Wet age-related macular degeneration (wet-AMD) is a leading cause of irreversible blindness. Current treatment of AMD requires monthly intravitreal injection, which is difficult to be implemented in many parts of the world. In recent years,...
Michelle E Turvey,Divakara S S M Uppu,Abdul Rahim Mohamed Sharif et al.
Michelle E Turvey et al.
Current live-attenuated dengue vaccines require strict cold chain storage. Methods to preserve dengue virus (DENV) viability, which enable vaccines to be transported and administered at ambient temperatures, will be decisive towards the imp...
A microfluidic model of human brain (μHuB) for assessment of blood brain barrier [0.03%]
人脑微流控模型(μHuB)，用于评估血脑屏障
Tyler D Brown,Maksymilian Nowak,Alexandra V Bayles et al.
Tyler D Brown et al.
Microfluidic cellular models, commonly referred to as "organs-on-chips," continue to advance the field of bioengineering via the development of accurate and higher throughput models, captivating the essence of living human organs. This clas...
Interpretation of the mechanism of action of antituberculosis drug bedaquiline based on a novel two-ion theory of energy coupling in ATP synthesis [0.03%]
基于ATP合成能量耦合新两离子理论的抗结核药贝达奎林作用机制探讨
Sunil Nath
Sunil Nath
Tuberculosis (TB) claims the lives of 1.3 million people each year, more than any other bacterial infection. Hence great interest was generated in health communities upon the recent introduction of the new diarylquinoline anti-TB drug, beda...
Device design methodology and formulation of a protein therapeutic for sustained release intraocular delivery [0.03%]
用于玻璃体内长期释放的蛋白药物递送装置设计方法学及制剂学研究
Erica B Schlesinger,Daniel A Bernards,Hunter H Chen et al.
Erica B Schlesinger et al.
Despite years of effort, sustained delivery of protein therapeutics remains an unmet need due to three primary challenges - dose, duration, and stability. The work presented here provides a design methodology for polycaprolactone reservoir-...
Polymeric curcumin nanoparticles by a facile in situ method for macrophage targeted delivery [0.03%]
一种简单的方法制备聚丙烯类姜黄素纳米颗粒用于巨噬细胞靶向递送
Priyanka S Jahagirdar,Pramod K Gupta,Savita P Kulkarni et al.
Priyanka S Jahagirdar et al.
Targeting macrophages is a promising strategy for improved therapy of intracellular infections as macrophages exhibit rapid phagocytosis of particles >200 nm. Entrapment of Curcumin (CUR) in nanocarriers could provide bioenhancement and mac...
Biodegradable bioadhesive nanoparticle incorporation of broad-spectrum organic sunscreen agents [0.03%]
可降解生物粘合剂纳米颗粒的广谱有机防晒剂的添加
Hee-Won Suh,Julia Lewis,Linda Fong et al.
Hee-Won Suh et al.
Conventional emulsion-based sunscreen formulations are limited by postapplication epicutaneous penetration that increases the risk of allergic dermatitis, cellular damage, and filter photodegradation upon ultraviolet radiation (UVR) exposur...