Ex vivo isolated human vessel perfusion system for the design and assessment of nanomedicines targeted to the endothelium [0.03%]
人血管灌注系统的设计与评估用于靶向内皮的纳米药物
Taras Lysyy,Laura G Bracaglia,Lingfeng Qin et al.
Taras Lysyy et al.
Endothelial cells play a central role in the process of inflammation. Their biologic relevance, as well as their accessibility to IV injected therapeutics, make them a strong candidate for treatment with molecularly-targeted nanomedicines. ...
Size, shape, and flexibility influence nanoparticle transport across brain endothelium under flow [0.03%]
尺寸、形状和柔韧性影响纳米颗粒在流动下的脑内皮运输
Maksymilian Nowak,Tyler D Brown,Adam Graham et al.
Maksymilian Nowak et al.
Nanoparticle-based therapeutic formulations are being increasingly explored for the treatment of various ailments. Despite numerous advances, the success of nanoparticle-based technologies in treating brain diseases has been limited. Transl...
Targeting functionalized nanoparticles to activated endothelial cells under high wall shear stress [0.03%]
靶向功能化纳米颗粒到高剪切力条件下的活化内皮细胞中
Hila Zukerman,Maria Khoury,Yosi Shammay et al.
Hila Zukerman et al.
Local inflammation of the endothelium is associated with a plethora of cardiovascular diseases. Vascular-targeted carriers (VTCs) have been advocated to provide focal effective therapeutics to these disease sites. Here, we examine the desig...
Remodeling adipose tissue inflammasome for type 2 diabetes mellitus treatment: Current perspective and translational strategies [0.03%]
重塑 adipose组织炎性小体治疗 2 型糖尿病：现状与转化策略
Amrita Banerjee,Jagdish Singh
Amrita Banerjee
Obesity-associated type 2 diabetes mellitus (T2DM) is characterized by low-grade chronic systemic inflammation that arises primarily from the white adipose tissue. The interplay between various adipose tissue-derived chemokines drives insul...
Aaron C Anselmo
Aaron C Anselmo
CRISPR/Cas9-mediated mutagenesis to validate the synergy between PARP1 inhibition and chemotherapy in BRCA1-mutated breast cancer cells [0.03%]
基于CRISPR/Cas9基因编辑技术验证PARP1抑制剂和化疗药物协同治疗BRCA1突变乳腺癌细胞系中的合成致死效应
Rachel L Mintz,Yeh-Hsing Lao,Chun-Wei Chi et al.
Rachel L Mintz et al.
For patients carrying BRCA1 mutations, at least one-third develop triple negative breast cancer (TNBC). Not only is TNBC difficult to treat due to the lack of molecular target receptors, but BRCA1 mutations (BRCA1m) also result in chemother...
Sprayable and biodegradable, intrinsically adhesive wound dressing with antimicrobial properties [0.03%]
一种具有抗菌性能的喷雾型可降解伤口敷料
John L Daristotle,Lung W Lau,Metecan Erdi et al.
John L Daristotle et al.
Conventional wound dressings are difficult to apply to large total body surface area (TBSA) wounds, as they typically are prefabricated, require a layer of adhesive coating for fixation, and need frequent replacement for entrapped exudate. ...
2D or 3D? How cell motility measurements are conserved across dimensions in vitro and translate in vivo [0.03%]
二维还是三维？体外细胞运动测量如何在不同维度下保持一致并在体内转化
Sualyneth Galarza,Hyuna Kim,Naciye Atay et al.
Sualyneth Galarza et al.
Cell motility is a critical aspect of several processes, such as wound healing and immunity; however, it is dysregulated in cancer. Current limitations of imaging tools make it difficult to study cell migration in vivo. To overcome this, an...
Injectable supramolecular polymer-nanoparticle hydrogels enhance human mesenchymal stem cell delivery [0.03%]
可注射的超分子聚合物-纳米颗粒水凝胶可以增强人类间充质干细胞的传递
Abigail K Grosskopf,Gillie A Roth,Anton A A Smith et al.
Abigail K Grosskopf et al.
Stem cell therapies have emerged as promising treatments for injuries and diseases in regenerative medicine. Yet, delivering stem cells therapeutically can be complicated by invasive administration techniques, heterogeneity in the injection...
Anjaney Kothari,Padmavathy Rajagopalan
Anjaney Kothari
The jejunum is the segment of the small intestine responsible for several metabolism and biotransformation functions. In this report, we have cultured rat jejunum explants in vitro and integrated them with hepatocyte cultures. We have also ...