Therapeutic potential of extracellular vesicle-associated long noncoding RNA [0.03%]
胞外囊泡关联的长链非编码RNA的治疗潜力
Louis J Born,John W Harmon,Steven M Jay
Louis J Born
Both extracellular vesicles (EVs) and long noncoding RNAs (lncRNAs) have been increasingly investigated as biomarkers, pathophysiological mediators, and potential therapeutics. While these two entities have often been studied separately, th...
The wasp venom antimicrobial peptide polybia-CP and its synthetic derivatives display antiplasmodial and anticancer properties [0.03%]
黄蜂毒液中的抗菌肽聚刺蚁酸肽及其合成衍生物具有抗疟和抗癌性能
Marcelo D T Torres,Adriana F Silva,Gislaine P Andrade et al.
Marcelo D T Torres et al.
The wasp venom-derived antimicrobial peptide polybia-CP has been previously shown to exhibit potent antimicrobial activity, but it is also highly toxic. Previously, using a physicochemical-guided peptide design strategy, we reversed its tox...
PRADA: Portable Reusable Accurate Diagnostics with nanostar Antennas for multiplexed biomarker screening [0.03%]
基于纳米星天线的便携可重复准确的多指标筛查设备PRADA
Xiaona Wen,Yu-Chuan Ou,Holly F Zarick et al.
Xiaona Wen et al.
Precise monitoring of specific biomarkers in biological fluids with accurate biodiagnostic sensors is critical for early diagnosis of diseases and subsequent treatment planning. In this work, we demonstrated an innovative biodiagnostic sens...
Current diagnostic tools for coronaviruses-From laboratory diagnosis to POC diagnosis for COVID-19 [0.03%]
冠状病毒的当前诊断工具：从COVID-19的实验室诊断到POC诊断
Yung-Chih Wang,Yi-Tzu Lee,Ting Yang et al.
Yung-Chih Wang et al.
The Coronavirus-2019 (COVID-19) pandemic has put tremendous strain on healthcare systems worldwide. It is challenging for clinicians to differentiate COVID-19 from other acute respiratory tract infections via clinical symptoms because those...
Aaron C Anselmo
Aaron C Anselmo
Employing drug delivery strategies to create safe and effective pharmaceuticals for COVID-19 [0.03%]
运用给药策略研发安全有效的新冠肺炎药物
Kevin J McHugh
Kevin J McHugh
Dendrimer size effects on the selective brain tumor targeting in orthotopic tumor models upon systemic administration [0.03%]
树枝状聚合物的尺寸对系统给药后原位脑肿瘤模型的选择性脑靶向的影响
Kevin Liaw,Fan Zhang,Antonella Mangraviti et al.
Kevin Liaw et al.
Malignant gliomas are the most common and aggressive form of primary brain tumors, with a median survival of 15-20 months for patients receiving maximal interventions. Advances in nanomedicine have provided tumor-specific delivery of chemot...
Inhalable bacteriophage powders: Glass transition temperature and bioactivity stabilization [0.03%]
吸入式噬菌体粉末：玻璃化转变温度及生物活性稳定化
Rachel Yoon Kyung Chang,Philip Chi Lip Kwok,Dipesh Khanal et al.
Rachel Yoon Kyung Chang et al.
Recent heightened interest in inhaled bacteriophage (phage) therapy for combating antibacterial resistance in pulmonary infections has led to the development of phage powder formulations. Although phages have been successfully bioengineered...
Hydrogels in the clinic [0.03%]
临床用水凝胶
Abhirup Mandal,John R Clegg,Aaron C Anselmo et al.
Abhirup Mandal et al.
Injectable hydrogels are one of the most widely investigated and versatile technologies for drug delivery and tissue engineering applications. Hydrogels' versatility arises from their tunable structure, which has been enabled by considerabl...
A self-adhesive microneedle patch with drug loading capability through swelling effect [0.03%]
一种可通过溶胀效应加载药物的自粘式微针贴片
Sharon W T Chew,Ankur H Shah,Mengjia Zheng et al.
Sharon W T Chew et al.
Microneedles (MNs) offer a rapid method of transdermal drug delivery through penetration of the stratum corneum. However, commercial translation has been limited by fabrication techniques unique to each drug. Herein, a broadly applicable pl...