Personalized-induced neural stem cell therapy: Generation, transplant, and safety in a large animal model [0.03%]
个性化诱导神经干细胞治疗：大型动物模型中的产生、移植及安全性研究
Hunter N Bomba,Kevin T Sheets,Alain Valdivia et al.
Hunter N Bomba et al.
In this study, we take an important step toward clinical translation by generating the first canine-induced neural stem cells (iNSCs). We explore key aspects of scale-up, persistence, and safety of personalized iNSC therapy in autologous ca...
Hyaluronic acid-doxorubicin nanoparticles for targeted treatment of colorectal cancer [0.03%]
透明质酸-多柔比星纳米颗粒靶向治疗结直肠癌研究
Daniel C Pan,Vinu Krishnan,Alyssa K Salinas et al.
Daniel C Pan et al.
Colorectal cancer, common in both men and women, occurs when tumors form in the linings of the colon. Common treatments of colorectal cancer include surgery, chemotherapy, and radiation therapy; however, many colorectal cancer treatments of...
Intradermal delivery of receptor-binding domain of SARS-CoV-2 spike protein with dissolvable microneedles to induce humoral and cellular responses in mice [0.03%]
一种可溶性微针系统诱导小鼠针对SARS-CoV-2刺突蛋白受体结合域的粘膜免疫响应
Chaiyaporn Kuwentrai,Jinming Yu,Li Rong et al.
Chaiyaporn Kuwentrai et al.
The S1 subunit of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) spike protein contains an immunogenic receptor-binding domain (RBD), which is a promising candidate for the development of a potential vaccine. This study demons...
Samir Mitragotri,Aaron C Anselmo
Samir Mitragotri
Oxidative pentose phosphate pathway and glucose anaplerosis support maintenance of mitochondrial NADPH pool under mitochondrial oxidative stress [0.03%]
氧化核糖磷酸途径和葡萄糖补料支持线粒体氧化应激下细胞NADPH库的维持
Sun Jin Moon,Wentao Dong,Gregory N Stephanopoulos et al.
Sun Jin Moon et al.
Mitochondrial NADPH protects cells against mitochondrial oxidative stress by serving as an electron donor to antioxidant defense systems. However, due to technical challenges, it still remains unknown as to the pool size of mitochondrial NA...
Screening method to identify hydrogel formulations that facilitate myotube formation from encapsulated primary myoblasts [0.03%]
筛选方法以识别促进包裹的一级肌细胞形成肌管的水凝胶配方
Dhananjay V Deshmukh,Nils Pasquero,Gajraj Rathore et al.
Dhananjay V Deshmukh et al.
Hydrogel-based three-dimensional (3D) cellular models are attractive for bioengineering and pharmaceutical development as they can more closely resemble the cellular function of native tissue outside of the body. In general, these models ar...
In situ forming microporous gelatin methacryloyl hydrogel scaffolds from thermostable microgels for tissue engineering [0.03%]
用于组织工程的热稳定微凝胶原位形成的微孔明胶甲基丙烯酰水凝胶支架
Nicole Zoratto,Donatella Di Lisa,Joseph de Rutte et al.
Nicole Zoratto et al.
Converting biopolymers to extracellular matrix (ECM)-mimetic hydrogel-based scaffolds has provided invaluable opportunities to design in vitro models of tissues/diseases and develop regenerative therapies for damaged tissues. Among biopolym...
Samir Mitragotri
Samir Mitragotri
Nanoparticle-microglial interaction in the ischemic brain is modulated by injury duration and treatment [0.03%]
缺血脑中纳米粒子-小胶质细胞相互作用受损伤持续时间和治疗的调节
Andrea Joseph,Rick Liao,Mengying Zhang et al.
Andrea Joseph et al.
Cerebral ischemia is a major cause of death in both neonates and adults, and currently has no cure. Nanotechnology represents one promising area of therapeutic development for cerebral ischemia due to the ability of nanoparticles to overcom...
The effect of size, charge, and peptide ligand length on kidney targeting by small, organic nanoparticles [0.03%]
尺寸，电荷和肽配体长度对小型有机纳米颗粒肾脏靶向的影响
Yi Huang,Kairui Jiang,Xuting Zhang et al.
Yi Huang et al.
Chronic kidney disease (CKD) affects 15% of the US adult population. However, most clinically available drugs for CKD show low bioavailability to the kidneys and non-specific uptake by other organs which results in adverse side effects. Hen...