Systemic administration of dendrimer N-acetyl cysteine improves outcomes and survival following cardiac arrest [0.03%]
系统给药树形聚丙烯酰胺-N-乙酰半胱氨酸可改善心脏骤停后的预后和生存率
Hiren R Modi,Qihong Wang,Sarah J Olmstead et al.
Hiren R Modi et al.
Cardiac arrest (CA), the sudden cessation of effective cardiac pumping function, is still a major clinical problem with a high rate of early and long-term mortality. Post-cardiac arrest syndrome (PCAS) may be related to an early systemic in...
Zongmin Zhao,Aaron C Anselmo,Samir Mitragotri
Zongmin Zhao
Gene therapies are currently one of the most investigated therapeutic modalities in both the preclinical and clinical settings and have shown promise in treating a diverse spectrum of diseases. Gene therapies aim at introducing a gene mater...
Matrix stiffness mechanosensing modulates the expression and distribution of transcription factors in Schwann cells [0.03%]
基质刚度力学传感调节施万细胞转录因子的表达和分布
Gonzalo Rosso,Daniel Wehner,Christine Schweitzer et al.
Gonzalo Rosso et al.
After peripheral nerve injury, mature Schwann cells (SCs) de-differentiate and undergo cell reprogramming to convert into a specialized cell repair phenotype that promotes nerve regeneration. Reprogramming of SCs into the repair phenotype i...
Radiation nanosensitizers in cancer therapy-From preclinical discoveries to the outcomes of early clinical trials [0.03%]
辐射型纳米增敏剂在癌症治疗中的应用——从前期研发到临床试验的成果
Colette Bilynsky,Nadine Millot,Anne-Laure Papa
Colette Bilynsky
Improving the efficacy and spatial targeting of radiation therapy while sparing surrounding normal tissues has been a guiding principle for its use in cancer therapy. Nanotechnologies have shown considerable growth in terms of innovation an...
Area light source-triggered latent angiogenic molecular mechanisms intensify therapeutic efficacy of adult stem cells [0.03%]
特定面积光源触发的潜在促血管生成分子机制可增强成体干细胞治疗效果
Yu-Jin Kim,Sung-Won Kim,Gwang-Bum Im et al.
Yu-Jin Kim et al.
Light-based therapy such as photobiomodulation (PBM) reportedly produces beneficial physiological effects in cells and tissues. However, most reports have focused on the immediate and instant effects of light. Considering the physiological ...
Transplantation of patient-specific bile duct bioengineered with chemically reprogrammed and microtopographically differentiated cells [0.03%]
化学重编程和微拓扑分化的人肝细胞胆管移植修复肝脏损伤
Elina Maria Buisson,Suk-Hee Park,Myounghoi Kim et al.
Elina Maria Buisson et al.
Cholangiopathy is a diverse spectrum of chronic progressive bile duct disorders with limited treatment options and dismal outcomes. Scaffold- and stem cell-based tissue engineering technologies hold great promise for reconstructive surgery ...
Mark Epshtein,Moran Levi,Afif M Kraitem et al.
Mark Epshtein et al.
Localized delivery of diagnostic/therapeutic agents to cerebral aneurysms, lesions in brain arteries, may offer a new treatment paradigm. Since aneurysm rupture leading to subarachnoid hemorrhage is a devastating medical emergency with high...
Neonatal microglia and proteinase inhibitors-treated adult microglia improve traumatic brain injury in rats by resolving the neuroinflammation [0.03%]
新生小胶质细胞和蛋白酶抑制剂处理的成人小胶质细胞通过消除神经炎症来改善大鼠创伤性脑损伤
Ping Zheng,Qingke Bai,Jiugeng Feng et al.
Ping Zheng et al.
Microglia participate in the regulation of neuroinflammation caused by traumatic brain injury (TBI). This research aimed to explore the repair effects of intracranial injection of neonatal microglia or protease-treated adult microglia on TB...
Implant-bone-interface: Reviewing the impact of titanium surface modifications on osteogenic processes in vitro and in vivo [0.03%]
种植体-骨界面：钛表面改性对体内外成骨过程影响的综述
Theresia Stich,Francisca Alagboso,Tomáš Křenek et al.
Theresia Stich et al.
Titanium is commonly and successfully used in dental and orthopedic implants. However, patients still have to face the risk of implant failure due to various reasons, such as implant loosening or infection. The risk of implant loosening can...
Long-acting and extended-release implant and nanoformulations with a synergistic antiretroviral two-drug combination controls HIV-1 infection in a humanized mouse model [0.03%]
一种长效的和缓释的植入剂及纳米配方与具有协同抗逆转录病毒作用的两药组合可控制人类免疫缺陷病毒感染人类免疫缺陷病毒人的鼠模型
Jagadish Beloor,Shalley N Kudalkar,Gina Buzzelli et al.
Jagadish Beloor et al.
The HIV pandemic has affected over 38 million people worldwide with close to 26 million currently accessing antiretroviral therapy (ART). A major challenge in the long-term treatment of HIV-1 infection is nonadherence to ART. Long-acting an...