A ferret brain slice model of oxygen-glucose deprivation captures regional responses to perinatal injury and treatment associated with specific microglial phenotypes [0.03%]
一种雪貂脑切片缺氧缺糖模型模拟了与特定小胶质细胞表型相关的围产期损伤和治疗的区域性反应
Thomas R Wood,Kate Hildahl,Hawley Helmbrecht et al.
Thomas R Wood et al.
Organotypic brain slice models are an ideal technological platform to investigate therapeutic options for hypoxic-ischemic (HI) brain injury, a leading cause of morbidity and mortality in neonates. The brain exhibits regional differences in...
Metal-HisTag coordination for remote loading of very small quantities of biomacromolecules into PLGA microspheres [0.03%]
金属-组氨酸标签配位远程向PLGA微球中装载极少量的生物大分子
Jason Albert,Rae Sung Chang,George A Garcia et al.
Jason Albert et al.
Challenges to discovery and preclinical development of long-acting release systems for protein therapeutics include protein instability, use of organic solvents during encapsulation, specialized equipment and personnel, and high costs of pr...
Ferrostatin-1-loaded liposome for treatment of corneal alkali burn via targeting ferroptosis [0.03%]
用于治疗角膜碱烧伤的Ferrostatin-1靶向脂质体以抑制铁死亡
Kai Wang,Li Jiang,Yueyang Zhong et al.
Kai Wang et al.
Alkali burn is a potentially blinding corneal injury. During the progression of alkali burn-induced injury, overwhelmed oxidative stress in the cornea triggers cell damage, including oxidative changes in cellular macromolecules and lipid pe...
Use of FLOSEAL® as a scaffold and its impact on induced neural stem cell phenotype, persistence, and efficacy [0.03%]
FLOSEAL作为支架及其对诱导神经干细胞表型、持续性和疗效的影响
Hunter N Bomba,Abigail Carey-Ewend,Kevin T Sheets et al.
Hunter N Bomba et al.
Induced neural stem cells (iNSCs) have emerged as a promising therapeutic platform for glioblastoma (GBM). iNSCs have the innate ability to home to tumor foci, making them ideal carriers for antitumor payloads. However, the in vivo persiste...
The microbiota-gut-brain axis and epilepsy from a multidisciplinary perspective: Clinical evidence and technological solutions for improvement of in vitro preclinical models [0.03%]
从多学科角度探讨微生态-肠-脑轴与癫痫：临床证据及改善体外实验模型的技术解决方案
Federica Fusco,Simone Perottoni,Carmen Giordano et al.
Federica Fusco et al.
Epilepsy is a common neurological disease characterized by the enduring predisposition of the brain to generate seizures. Among the recognized causes, a role played by the gut microbiota in epilepsy has been hypothesized and supported by ne...
Wade T Johnson,Nicholas C Dorn,Dora A Ogbonna et al.
Wade T Johnson et al.
Lipids constitute a diverse class of molecular regulators with ubiquitous physiological roles in sustaining life. These carbon-rich compounds are primarily sourced from exogenous sources and may be used directly as structural cellular build...
Gowhar A Naikoo,Fareeha Arshad,Israr U Hassan et al.
Gowhar A Naikoo et al.
With the threat of increasing SARS-CoV-2 cases looming in front of us and no effective and safest vaccine available to curb this pandemic disease due to its sprouting variants, many countries have undergone a lockdown 2.0 or planning a lock...
Transplantation of bioengineered Reelin-loaded PLGA/PEG micelles can accelerate neural tissue regeneration in photothrombotic stroke model of mouse [0.03%]
载有Reelin的生物工程PLGA/PEG胶束移植加速了小鼠光凝血性卒中模型中的神经组织再生
Zahra Shabani,Reza Rahbarghazi,Mohammad Karimipour et al.
Zahra Shabani et al.
Ischemic stroke is characterized by extensive neuronal loss, glial scar formation, neural tissue degeneration that leading to profound changes in the extracellular matrix, neuronal circuitry, and long-lasting functional disabilities. Althou...
High-dose vitamin D metabolite delivery inhibits breast cancer metastasis [0.03%]
高剂量维生素D代谢物递送可抑制乳腺癌转移
Jiaye Liu,Junyi Shen,Chunyang Mu et al.
Jiaye Liu et al.
Besides its well-known benefits on human health, calcitriol, the hormonally active form of vitamin D3, has been being evaluated in clinical trials as an anticancer agent. However, currently available results are contradictory and not fundam...
Rare earth smart nanomaterials for bone tissue engineering and implantology: Advances, challenges, and prospects [0.03%]
用于骨组织工程和植入牙科学的稀土智能纳米材料：进展、挑战及展望
Duraipandy Natarajan,Zhitong Ye,Liping Wang et al.
Duraipandy Natarajan et al.
Bone grafts or prosthetic implant designing for clinical application is challenging due to the complexity of integrated physiological processes. The revolutionary advances of nanotechnology in the biomaterial field expedite and endorse the ...