Engineering macrophage phenotype switching via nucleotide-binding oligomerization domain-like receptor protein 3 inflammasome inhibition: A translational approach using antibiotic cement for diabetic foot ulcers [0.03%]
通过核苷酸结合寡聚化结构域样受体蛋白3炎性小体抑制工程化巨噬细胞表型转换：使用抗生素水泥治疗糖尿病足溃疡的转化方法
Yi Zhang,Fusen Jia,Ming Li et al.
Yi Zhang et al.
Diabetic foot ulcers (DFUs), a debilitating complication of diabetes, are exacerbated by persistent inflammation that disrupts wound repair. This study explores the therapeutic potential of antibiotic-loaded bone cement (ALBC) in modulating...
Enhancing peripheral nerve regeneration through NaOH-based decellularization of human nerve tissue [0.03%]
基于NaOH脱细胞的人神经组织促进周围神经再生
Subin Kim,Seong Hyuk Park,Jiyeon Mun et al.
Subin Kim et al.
Peripheral nerves are vulnerable to trauma, pressure, and surgical injuries, complicating the regeneration process. While the autograft remains the gold standard for recovery, limitations such as tissue availability and donor site morbiditi...
A novel brachytherapy and chemotherapy integrated ureteral stent: In vitro and in vivo study [0.03%]
一种新型的近距离放射治疗和化学疗法相结合的输尿管支架：体外和体内研究
Xiaotian Yang,Xueliang Zhou,Zhanyun Zhou et al.
Xiaotian Yang et al.
Ureteral carcinoma remains a major clinical challenge and requires effective localized treatment. Here, we report a novel 125I seed brachytherapy (ISB) and doxorubicin (DOX) chemotherapy integrated ureteral stent (IUS), which enables simult...
Bioprinting revolution: Innovative design of 3D bioactive scaffolds for living organs and transdermal tissues [0.03%]
生物打印革命：活组织和透皮组织的3D生物活性支架的创新设计
Seydanur Yücer,Begüm Sarac,Fatih Ciftci
Seydanur Yücer
The bioprinting revolution has opened new frontiers in the design and fabrication of three-dimensional bioactive scaffolds for living organs and transdermal tissues. This transformative technology enables the precise assembly of biomaterial...
Biomaterials-driven stem cell therapy for tissue repair and functional rehabilitation after ischemic stroke [0.03%]
基于生物材料的干细胞治疗在缺血性脑卒中后组织修复及功能康复中的作用
Mengjie Wang,Yuanyuan Ran,Jianshen Liang et al.
Mengjie Wang et al.
Ischemic stroke is a serious cerebrovascular disease with limited effective treatments. While stem cell therapy shows promise, ensuring cell survival and integration into neural networks remains a challenge. Recent research shows tissue eng...
Engineering a smart intrauterine device based on pH-controlled copper release [0.03%]
一种基于pH控制铜释放的智能宫内节育装置的设计
Greta Bertola,Florinda Coro,Arti Ahluwalia et al.
Greta Bertola et al.
Contraceptive methods based on intrauterine devices (IUD) typically result in women being constantly exposed to either hormones or copper ions. Although it is well known that the pH in vaginal fluids increases from around 3.5 to 7 during in...
Developing a process of lentivirus purification from recombinant fluids using peptide affinity ligands [0.03%]
利用肽亲和配体从重组液中开发慢病毒纯化工艺
Eduardo Barbieri,Gina N Mollica,Sobhana A Sripada et al.
Eduardo Barbieri et al.
Lentiviral vectors (LVVs) are emerging as an enabling tool in gene and cell therapies, yet the toolkit for purifying them at scale is still immature. A pivoting moment in LVV isolation technology was marked by the introduction of affinity l...
Cell therapies against brain tumors: Clinical development and emerging prospects [0.03%]
脑肿瘤的细胞疗法：临床开发和前景展望
Tatsuya Fukuta,Suyog Shaha,Andres da Silva-Candal et al.
Tatsuya Fukuta et al.
Malignant brain tumors, particularly glioblastoma multiforme (GBM), are aggressive and fatal cancers. The clinical efficacy of current standard-of-care treatments against brain tumors has been minimal, with no significant improvement over t...
Paquinimod-hydrogel hybrid microneedle array patch alleviates hypertrophic scar via inhibiting M1 polarization [0.03%]
帕金尼咪唑-水凝胶混合微针贴片通过抑制M1极化缓解增生性疤痕
Zihui Zhang,Peng Wang,Hengdeng Liu et al.
Zihui Zhang et al.
Hypertrophic scar (HS) is one of the most common complications of skin injuries, with a lack of effective therapeutic approaches to date. Most current research has focused on the dysfunction of hypertrophic scar fibroblasts (HSFBs) and derm...
Enhancement of spinal cord injury repair in rats using photo-crosslinked GelMA hydrogel combined with mitochondrial transplantation [0.03%]
结合线粒体移植的光交联明胶甲基丙烯酸酯水凝胶增强大鼠脊髓损伤修复效果
Wenyong Gao,Can Tang,Diancheng Hang et al.
Wenyong Gao et al.
Acute spinal cord injury (SCI) induces mitochondrial oxidative stress, cellular bioenergetic crises, impaired protein degradation, and subsequent degeneration, resulting in increased neuronal vulnerability. Transplantation of exogenous mito...