Multifunctional electrospun asymmetric wettable membrane containing black phosphorus/Rg1 for enhancing infected wound healing [0.03%]
含黑色磷/rg1的多功能电纺不对称亲水膜促进感染伤口愈合
Liming Zhou,Nanbo Liu,Longbao Feng et al.
Liming Zhou et al.
Bacterial infection is one of the most frequent complications in the burn and chronic wounds. Inspired by natural existing superhydrophobic surface structures, a novel asymmetric wettable membrane was prepared using the electrospinning tech...
Synergistic strategy with hyperthermia therapy based immunotherapy and engineered exosomes-liposomes targeted chemotherapy prevents tumor recurrence and metastasis in advanced breast cancer [0.03%]
基于免疫治疗和工程化外泌体-脂质体靶向化疗的协同策略可预防三阴性乳腺癌复发及转移
Haiqin Huang,Lanlan Shao,Yan Chen et al.
Haiqin Huang et al.
Advanced breast cancer with recurrent and distal organ metastasis is aggressive and incurable. The current existing treatment strategies for advanced breast cancer are difficult to achieve synergistic treatment of recurrent tumors and dista...
Engineering a switchable single-chain TEV protease to control protein maturation in living neurons [0.03%]
工程化可调控单链TEV蛋白酶以控制活神经元中蛋白质成熟
Pietro Renna,Cristian Ripoli,Onur Dagliyan et al.
Pietro Renna et al.
Engineered proteases are promising tools to address physiological and pathophysiological questions as well as to develop new therapeutic approaches. Here we introduce a new genetically encoded engineered single-chain tobacco etch virus prot...
Development of di(2-ethylhexyl) phthalate-containing thioglycolic acid immobilized chitosan mucoadhesive gel as an alternative hormone therapy for menopausal syndrome [0.03%]
开发含邻苯二甲酸二丁酯的硫代甘醇酸壳聚糖粘膜凝胶作为绝经期综合征替代激素治疗的新方法研究
I-Hsuan Yang,I-En Lin,Ya-Jyun Liang et al.
I-Hsuan Yang et al.
Menopausal syndrome includes the symptoms that most women experience owing to hormone changes after menopause. Although hormone replacement therapy is a common treatment for menopausal syndrome, there are still many side effects and challen...
LINC00473-modified bone marrow mesenchymal stem cells incorporated thermosensitive PLGA hydrogel transplantation for steroid-induced osteonecrosis of femoral head: A detailed mechanistic study and validity evaluation [0.03%]
经LINC00473修饰的骨髓间充质干细胞载药热敏PLGA水凝胶移植治疗糖皮质激素致股骨头坏死：详细机制研究及有效性评估
Yingxing Xu,Yaping Jiang,Yingzhen Wang et al.
Yingxing Xu et al.
The pathogenesis of steroid-induced osteonecrosis of the femoral head (SONFH) involves a glucocorticoid-induced imbalance of osteogenic and adipogenic differentiation, and apoptosis of bone marrow mesenchymal stem cells (BMSCs). An increasi...
Tango of dual nanoparticles: Interplays between exosomes and nanomedicine [0.03%]
双纳米颗粒探戈：外泌体与纳米药物的相互作用
Yabin Wang,Wenzhen Wang,Fangong Kong et al.
Yabin Wang et al.
Exosomes are lipid bilayer vesicles released from cells as a mechanism of intracellular communication. Containing information molecules of their parental cells and inclining to fuse with targeted cells, exosomes are valuable in disease diag...
Multistage targeting and dual inhibiting strategies based on bioengineered tumor matrix microenvironment-mediated protein nanocages for enhancing cancer biotherapy [0.03%]
基于生物工程化肿瘤基质微环境介导的蛋白纳米笼的多级靶向和双重抑制策略，增强癌症生物治疗
Fabiao Hu,Changping Deng,Yiwen Zhou et al.
Fabiao Hu et al.
Regulation of the apoptotic pathway plays a critical role in inducing tumor cell death and circumventing drug resistance. Survivin protein is the strongest inhibitor of apoptosis found so far. It is highly expressed in several cancers and i...
Monocytes engineered with iSNAP inhibit human B-lymphoma progression [0.03%]
用iSNAP工程设计的单核细胞可抑制人类B淋巴瘤的发展
Haohsiang Wu,Siamak Amirfakhri,Hsin-Hung Lin et al.
Haohsiang Wu et al.
Monocytes are important regulators for the maintenance of homeostasis in innate and adaptive immune system and have been reported to play important role in cancer progression. CD47-SIRPα recognition is a coinhibitory immune signal to inhib...
The efficiency of MSC-based targeted AIE nanoparticles for gastric cancer diagnosis and treatment: An experimental study [0.03%]
基于MSC的靶向AIE纳米颗粒在胃癌诊疗中的效率：实验研究
Sushan Ouyang,Yi Zhang,Sheng Yao et al.
Sushan Ouyang et al.
Mesenchymal stem cells (MSCs), due to their tumor tropism, are strongly recruited by various solid tumors and mobilized by inflammatory signals in the tumor microenvironment. However, effective cellular uptake is critical for MSC-based drug...
Macrophage-targeted delivery of siRNA to silence Mecp2 gene expression attenuates pulmonary fibrosis [0.03%]
靶向巨噬细胞递送Mecp2基因siRNA沉默表达减轻肺纤维化
Yong Mou,Guo-Rao Wu,Qi Wang et al.
Yong Mou et al.
Idiopathic pulmonary fibrosis (IPF) is a progressive interstitial lung disease characterized by the infiltration of macrophages in the fibrotic region. Currently, no therapeutic strategies effectively control disease progression, and the 5-...