"Musical dish" efficiently induces osteogenic differentiation of mesenchymal stem cells through music derived microstretch with variable frequency [0.03%]
基于频率可变音乐提取微拉伸的“音乐培养皿”高效诱导间充质干细胞成骨分化
Qiulin He,Junxin Lin,Fanghao Zhou et al.
Qiulin He et al.
Nonuniform microstretching (NUMS) naturally occurs in real bone tissues in vivo, but its profound effects have not been identified yet. In order to explore the biological effects of NUMS and static stretch (uniform stretch [US]) on cells, a...
Design and clinical application of injectable hydrogels for musculoskeletal therapy [0.03%]
可注射型水凝胶的制备及其在骨科疾病治疗中的应用研究
Øystein Øvrebø,Giuseppe Perale,Jonathan P Wojciechowski et al.
Øystein Øvrebø et al.
Musculoskeletal defects are an enormous healthcare burden and source of pain and disability for individuals. With an aging population, the proportion of individuals living with these medical indications will increase. Simultaneously, there ...
Predicting T-cell quality during manufacturing through an artificial intelligence-based integrative multiomics analytical platform [0.03%]
基于人工智能的综合多组学分析平台在制造过程中预测T细胞质量
Valerie Y Odeh-Couvertier,Nathan J Dwarshuis,Maxwell B Colonna et al.
Valerie Y Odeh-Couvertier et al.
Large-scale, reproducible manufacturing of therapeutic cells with consistently high quality is vital for translation to clinically effective and widely accessible cell therapies. However, the biological and logistical complexity of manufact...
TIMP-1-expressing breast tumor spheroids for the evaluation of drug penetration and efficacy [0.03%]
表达TIMP-1的乳腺肿瘤类器官用于评估药物渗透及疗效
In Yeong Bae,Wooshik Choi,Seung Ja Oh et al.
In Yeong Bae et al.
Abundance of stromal cells and extracellular matrix (ECM) is observed in breast cancer, acting as a barrier for drug penetration and presenting a key issue for developing efficient therapeutics. In this study, we aimed to develop a three-di...
Development of a stem cell spheroid-laden patch with high retention at skin wound site [0.03%]
一种高保留在皮肤伤口处的干细胞球状体敷料的开发
Gun-Jae Jeong,Gwang-Bum Im,Tae-Jin Lee et al.
Gun-Jae Jeong et al.
Mesenchymal stem cells such as human adipose tissue-derived stem cells (hADSCs) have been used as a representative therapeutic agent for tissue regeneration because of their high proliferation and paracrine factor-secreting abilities. Howev...
Two diverse carriers are better than one: A case study in α-particle therapy for prostate specific membrane antigen-expressing prostate cancers [0.03%]
双重载荷优于单一载荷——以前列腺特异性膜抗原阳性前列腺癌α粒子治疗为例的一项研究
Dominick Salerno,Alaina Howe,Omkar Bhatavdekar et al.
Dominick Salerno et al.
Partial and/or heterogeneous irradiation of established (i.e., large, vascularized) tumors by α-particles that exhibit only a 4-5 cell-diameter range in tissue, limits the therapeutic effect, since regions not being hit by the high energy ...
Fibrin-specific poly(N-isopropylacrylamide) nanogels for targeted delivery of tissue-type plasminogen activator to treat thrombotic complications are well tolerated in vivo [0.03%]
组织型纤溶酶原激活物治疗血栓并发症的富纤维蛋白纳米凝胶在体内具有良好的耐受性
Emily P Mihalko,Kimberly Nellenbach,Manasi Krishnakumar et al.
Emily P Mihalko et al.
Targeted drug delivery for maintaining blood fluidity can reduce the risks associated with systemic anticoagulants that can lead to off-target bleeding. Recently, there has been much interest in targeted delivery of tissue-type plasminogen ...
A biomimetic hyaluronic acid-silk fibroin nanofiber scaffold promoting regeneration of transected urothelium [0.03%]
一种促进尿道上皮端-to-端缺损修复的仿生透明质酸-丝素蛋白纳米纤维支架
Yuqing Niu,Massimiliano Galluzzi,Fuming Deng et al.
Yuqing Niu et al.
This study was designed to investigate the regulatory effect of hyaluronic acid (HA)-coating silk fibroin (SF) nanofibers during epithelialization of urinary tract for urethral regeneration. The obtained electrospun biomimetic tubular HA-SF...
Ventilation-induced epithelial injury drives biological onset of lung trauma in vitro and is mitigated with prophylactic anti-inflammatory therapeutics [0.03%]
通风诱发的上皮损伤驱动体外肺损伤的生物学起始并可通过预防性抗炎药物缓解
Eliram Nof,Arbel Artzy-Schnirman,Saurabh Bhardwaj et al.
Eliram Nof et al.
Mortality rates among patients suffering from acute respiratory failure remain perplexingly high despite the maintenance of blood oxygen homeostasis during ventilatory support. The biotrauma hypothesis advocates that mechanical forces from ...
Graphene quantum dots-based targeted nanoprobes detecting drug delivery, imaging, and enhanced chemotherapy of nasopharyngeal carcinoma [0.03%]
石墨烯量子点靶向纳probe检测药物递送、成像及增强鼻咽癌化疗
Chaosheng Yu,Zhen Long,Qianhui Qiu et al.
Chaosheng Yu et al.
One of the main clinical treatments for advanced nasopharyngeal carcinoma is chemotherapy, but systemic administration can cause serious adverse reactions. New type of nanomaterial which can actively targeting, imaging, and treating nasopha...