Extracellular matrix stiffness controls cardiac valve myofibroblast activation through epigenetic remodeling [0.03%]
细胞外基质刚度通过表观遗传重编程控制心脏瓣膜肌成纤维细胞活化
Cierra J Walker,Dilara Batan,Carrie T Bishop et al.
Cierra J Walker et al.
Aortic valve stenosis (AVS) is a progressive fibrotic disease that is caused by thickening and stiffening of valve leaflets. At the cellular level, quiescent valve interstitial cells (qVICs) activate to myofibroblasts (aVICs) that persist w...
Evaluation of native and non-native biomaterials for engineering human skin tissue [0.03%]
用于工程化人类皮肤组织的本土和非本土生物材料的评估
Carolina Motter Catarino,Katharina Kaiser,Tânia Baltazar et al.
Carolina Motter Catarino et al.
A variety of human skin models have been developed for applications in regenerative medicine and efficacy studies. Typically, these employ matrix molecules that are derived from non-human sources along with human cells. Key limitations of s...
Simultaneous detection of sepsis host response biomarkers in whole blood using electrochemical biosensor [0.03%]
用于全血中脓毒症宿主反应生物标志物的同时电化学生物传感器检测方法
Ambalika S Tanak,Abha Sardesai,Sriram Muthukumar et al.
Ambalika S Tanak et al.
Sepsis is a silent killer, caused by a syndromic reaction of the body's immune system to an infection that is typically the ultimate pathway to mortality due to numerous infectious diseases, including COVID-19 across the world. In the Unite...
A bioprinted complex tissue model for myotendinous junction with biochemical and biophysical cues [0.03%]
具有生化和生物物理刺激的肌腱结合部生物打印复杂组织模型
Won Jin Kim,Geun Hyung Kim
Won Jin Kim
In the musculoskeletal system, the myotendinous junction (MTJ) is optimally designed from the aspect of force transmission generated from a muscle through a tendon onto the bone to induce movement. Although the MTJ is a key complex tissue i...
Ali Taghizadeh,Mohsen Taghizadeh,Mohsen Khodadadi Yazdi et al.
Ali Taghizadeh et al.
After several billions of years, nature still makes decisions on its own to identify, develop, and direct the most effective material for phenomena/challenges faced. Likewise, and inspired by the nature, we learned how to take steps in deve...
An updated review of SARS-CoV-2 detection methods in the context of a novel coronavirus pandemic [0.03%]
新型冠状病毒大流行背景下SARS-CoV-2检测方法研究进展更新
Yuxuan Zhang,Zhiwei Huang,Jiajie Zhu et al.
Yuxuan Zhang et al.
The World Health Organization has reported approximately 430 million confirmed cases of coronavirus disease 2019 (COVID-19), caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), worldwide, including nearly 6 million death...
Finger stick blood test to assess postvaccination SARS-CoV-2 neutralizing antibody response against variants [0.03%]
用于评估对变异株的疫苗接种后中和抗体反应的指尖血液检测
Sing Mei Lim,Hoi Lok Cheng,Huan Jia et al.
Sing Mei Lim et al.
There is clinical need for a quantifiable point-of-care (PoC) SARS-CoV-2 neutralizing antibody (nAb) test that is adaptable with the pandemic's changing landscape. Here, we present a rapid and semi-quantitative nAb test that uses finger sti...
Resolvin D1-loaded nanoliposomes promote M2 macrophage polarization and are effective in the treatment of osteoarthritis [0.03%]
载有 Resolve D1 的纳米脂质体促进 M2 巨噬细胞极化并有效治疗骨关节炎
Ameya A Dravid,Kaamini M Dhanabalan,Smriti Agarwal et al.
Ameya A Dravid et al.
Current treatments for osteoarthritis (OA) offer symptomatic relief but do not prevent or halt the disease progression. Chronic low-grade inflammation is considered a significant driver of OA. Specialized proresolution mediators are powerfu...
Long term therapeutic effects of icariin-loaded PLGA microspheres in an experimental model of optic nerve ischemia via modulation of CEBP-β/G-CSF/noncanonical NF-κB axis [0.03%]
通过调节CEBP-β/G-CSF/非经典NF-κB轴，载伊卡瑞林PLGA微球治疗性递送长期缓解视神经缺血的实验研究
Tushar Dnyaneshwar Desai,Yao-Tseng Wen,Jayasimha Rayalu Daddam et al.
Tushar Dnyaneshwar Desai et al.
An ischemic insult at optic nerve (ON) is followed by detrimental neuroinflammation that results in progressive and long-lasting retinal ganglion cell (RGC) death and vision loss. Icariin was reported to be a safe and effective natural anti...
Exosomes derived from olfactory ensheathing cells provided neuroprotection for spinal cord injury by switching the phenotype of macrophages/microglia [0.03%]
嗅鞘细胞来源的外泌体通过改变巨噬细胞/小胶质细胞表型治疗脊髓损伤
Hong Fan,Zhe Chen,Hai-Bin Tang et al.
Hong Fan et al.
Transplantation of olfactory ensheathing cells (OECs) has been demonstrated to be beneficial for spinal cord injury (SCI) by modulating neuroinflammation, supporting neuronal survival and promoting angiogenesis. Besides OECs, the conditione...