Cell loaded hydrogel containing Ag-doped bioactive glass-ceramic nanoparticles as skin substitute: Antibacterial properties, immune response, and scarless cutaneous wound regeneration [0.03%]
一种皮肤替代品：含Ag掺杂生物活性玻璃陶瓷纳米颗粒的细胞载水凝胶的抗菌性能，免疫反应及无瘢痕创面修复作用
Esmaeel Sharifi,Seyede Athar Sadati,Satar Yousefiasl et al.
Esmaeel Sharifi et al.
An ideal tissue-engineered dermal substitute should possess angiogenesis potential to promote wound healing, antibacterial activity to relieve the bacterial burden on skin, as well as sufficient porosity for air and moisture exchange. In li...
Targeted brain delivery of RVG29-modified rifampicin-loaded nanoparticles for Alzheimer's disease treatment and diagnosis [0.03%]
一种用于阿尔茨海默病治疗和诊断的RVG29修饰的 Rifampicin 载药纳米颗粒的脑靶向递送方法研究
Ruiyi Zhou,Lihong Zhu,Zhaohao Zeng et al.
Ruiyi Zhou et al.
Alzheimer's disease (AD) is an aging-related neurodegenerative disease. The main pathological features of AD are β-amyloid protein (Aβ) deposition and tau protein hyperphosphorylation. Currently, there are no effective drugs for the etiol...
Fabrication of bone-derived decellularized extracellular matrix/ceramic-based biocomposites and their osteo/odontogenic differentiation ability for dentin regeneration [0.03%]
基于骨衍生脱细胞基质/陶瓷生物复合材料的牙本质再生修复能力研究
Dongyun Kim,Hyeongjin Lee,Geum-Hwa Lee et al.
Dongyun Kim et al.
The goal of this study was to fabricate bioactive cell-laden biocomposites supplemented with bone-derived decellularized extracellular matrix (dECM) with calcium phosphate ceramic, and to assess the effect of the biocomponents on the osteog...
Atomic force spectroscopy-based essay to evaluate oocyte postovulatory aging [0.03%]
基于原子力光谱技术评价卵母细胞老化的方法学研究
Alice Battistella,Laura Andolfi,Michele Zanetti et al.
Alice Battistella et al.
Postovulatory aging is a process occurring in the mature (MII) oocyte leading the unfertilized ones to apoptosis. The optimal time window of fertility for different mammalian species after oocytes maturation depends on its timeliness: the h...
Photoresponsive prodrug-dye nanoassembly for in-situ monitorable cancer therapy [0.03%]
用于原位监测的光响应型前药-荧光染料纳米复合物癌症治疗体系
Kaiqi Long,Yifan Wang,Wen Lv et al.
Kaiqi Long et al.
Photocleavable prodrugs enable controllable drug delivery to target sites modulated by light irradiation. However, the in vivo utility is usually hindered by their insolubility and inefficient delivery. In this study, we report a simple str...
Carboxymethyl chitosan prolongs adenovirus-mediated expression of IL-10 and ameliorates hepatic fibrosis in a mouse model [0.03%]
羧甲基壳聚糖延长腺病毒介导的IL-10表达并改善小鼠肝纤维化模型中的肝纤维化病情
Yannian Gou,Yaguang Weng,Qian Chen et al.
Yannian Gou et al.
Effective and safe liver-directed gene therapy has great promise in treating a broad range of liver diseases. While adenoviral (Ad) vectors have been widely used for efficacious in vivo gene delivery, their translational utilities are sever...
The effect of local non-thermal plasma therapy on the cancer-immunity cycle in a melanoma mouse model [0.03%]
局灶性非热等离子体治疗对黑色素瘤小鼠模型中抗癌免疫循环的影响
Abraham Lin,Joey De Backer,Delphine Quatannens et al.
Abraham Lin et al.
Melanoma remains a deadly cancer despite significant advances in immune checkpoint blockade and targeted therapies. The incidence of melanoma is also growing worldwide, which highlights the need for novel treatment options and strategic com...
Developing a new treatment for superficial fungal infection using antifungal Collagen-HSAF dressing [0.03%]
一种用于浅表真菌感染的抗真菌胶原-hsaf敷料的新疗法研究
Jing Zhong,Xiayi Yan,Xin Zuo et al.
Jing Zhong et al.
Fungal pathogens are common causes of superficial clinical infection. Their increasing drug resistance gradually makes existing antifungal drugs ineffective. Heat stable antifungal factor (HSAF) is a novel antifungal natural product with a ...
Biofabricated macrophage and fibroblast membranes synergistically promote skin wound healing [0.03%]
生物工程化的巨噬细胞和成纤维细胞膜协同促进皮肤伤口愈合
Dongqing Wang,Heying Chen,Li Lei et al.
Dongqing Wang et al.
Effective skin wound healing is a complex process involving anti-inflammation, fibrosis, matrix reconstruction, and angiogenesis. This work aimed to integrate the macrophage-mediated anti-inflammation and fibroblast-assisted matrix reconstr...
Transplantation of neuron-inducing grafts embedding positively charged gold nanoparticles for the treatment of spinal cord injury [0.03%]
负载带正电荷金纳米粒子的诱导神经移植物桥接修复脊髓损伤
Wan-Kyu Ko,Seong Jun Kim,Gong Ho Han et al.
Wan-Kyu Ko et al.
In this study, we aimed to investigate the recovery after traumatic spinal cord injury (SCI) by inducing cellular differentiation of transplanted neural stem cells (NSCs) into neurons. We dissociated NSCs from the spinal cords of Fisher 344...