Jelena Ochs,Mariana P Hanga,Georgina Shaw et al.
Jelena Ochs et al.
Advanced therapeutic medicinal products (ATMPs) have emerged as novel therapies for untreatable diseases, generating the need for large volumes of high-quality, clinically-compliant GMP cells to replace costly, high-risk and limited scale m...
Shanghui Huang,Xiangqian Hong,Mingyi Zhao et al.
Shanghui Huang et al.
Nanomaterials' unique structures at the nanometer level determine their incredible functions, and based on this, they can be widely used in the field of nanomedicine. However, nanomaterials do possess disadvantages that cannot be ignored, s...
Adaptive multi-degree-of-freedom in situ bioprinting robot for hair-follicle-inclusive skin repair: A preliminary study conducted in mice [0.03%]
一种用于包括毛囊的皮肤修复的在体多自由度生物打印机器人：初步研究（以小鼠为模型）
Wenxiang Zhao,Haiyan Chen,Yi Zhang et al.
Wenxiang Zhao et al.
Skin acts as an essential barrier, protecting organisms from their environment. For skin trauma caused by accidental injuries, rapid healing, personalization, and functionality are vital requirements in clinical, which are the bottlenecks h...
Ex vivo anchored PD-L1 functionally prevent in vivo renal allograft rejection [0.03%]
体外锚定的PD-L1能功能性地预防同种异体肾移植排斥反应
Zihuan Luo,Tao Liao,Yannan Zhang et al.
Zihuan Luo et al.
Organ transplantation is the optimal treatment for patients with end-stage diseases. T cell activation is a major contributing factor toward the trigger of rejection. Induction therapy with T cell depleting agent is a common option but incr...
Hyperelastic, shape-memorable, and ultra-cell-adhesive degradable polycaprolactone-polyurethane copolymer for tissue regeneration [0.03%]
用于组织再生的超弹性、形状记忆和超细胞粘附可降解聚己内酯-聚氨酯共聚物
Suk-Min Hong,Ji-Young Yoon,Jae-Ryung Cha et al.
Suk-Min Hong et al.
Novel polycaprolactone-based polyurethane (PCL-PU) copolymers with hyperelasticity, shape-memory, and ultra-cell-adhesion properties are reported as clinically applicable tissue-regenerative biomaterials. New isosorbide derivatives (propoxy...
Vascularized lymph node transplantation successfully reverses lymphedema and maintains immunity in a rat lymphedema model [0.03%]
血管化淋巴结移植成功逆转淋巴水肿并维持免疫功能的实验研究
Ahmet Hamdi Sakarya,Chi-Wei Huang,Chin-Yu Yang et al.
Ahmet Hamdi Sakarya et al.
Vascularized lymph node transplantation (VLNT) has shown inspiring results for the treatment of lymphedema. Nevertheless, it remains unclear how VLNT restores lymphatic drainage and whether or not immunity recovers after surgery. Hindlimb l...
Anterior substitutional urethroplasty using a biomimetic poly-l-lactide nanofiber membrane: Preclinical and clinical outcomes [0.03%]
一种用于前尿道重建的仿生聚左旋乳酸纳米纤维补片的临床前及临床疗效研究
Lujie Song,Kunxue Deng,Wei Yuan et al.
Lujie Song et al.
The aim of this study is to investigate the feasibility and efficacy of a novel biomimetic poly-l-lactide (PLLA) nanofiber membrane in repairing anterior urethral strictures from both preclinic and clinic. Biomimetic PLLA membrane was fabri...
An EPO-loaded multifunctional hydrogel synergizing with adipose-derived stem cells restores neurogenic erectile function via enhancing nerve regeneration and penile rehabilitation [0.03%]
负载EPO多功能水凝胶通过促进神经再生和阴茎康复与脂肪基质干细胞协同作用恢复神经源性勃起功能
Jun Shao,Pan Nie,Wende Yang et al.
Jun Shao et al.
Neurogenic erectile dysfunction (nED) is one of the most common and intractable postoperative complications of rectal and prostate cancer surgery and sometimes accompanies patients lifelong. The transplantation of stem cells has been proved...
Advanced strategies to thwart foreign body response to implantable devices [0.03%]
植入式装置的抗异物反应的高级策略研究进展
Simone Capuani,Gulsah Malgir,Corrine Ying Xuan Chua et al.
Simone Capuani et al.
Mitigating the foreign body response (FBR) to implantable medical devices (IMDs) is critical for successful long-term clinical deployment. The FBR is an inevitable immunological reaction to IMDs, resulting in inflammation and subsequent fib...
Blood vessel remodeling in late stage of vascular network reconstruction is essential for peripheral nerve regeneration [0.03%]
血管网络重建晚期的血管重塑对周围神经再生至关重要
Gang Wang,Panjian Lu,Pingping Qiao et al.
Gang Wang et al.
One of the bottlenecks of advanced study on tissue engineering in regenerative medicine is rapid and functional vascularization. For a deeper comprehension of vascularization, the exhaustive, dynamic, and three-dimensional depiction of perf...