Stable nebulization and muco-trapping properties of regdanvimab/IN-006 support its development as a potent, dose-saving inhaled therapy for COVID-19 [0.03%]
regdanvimab/IN-006稳定的雾化和黏液捕获特性支持其作为治疗COVID-19的有力且节省剂量的吸入型疗法进行开发
Morgan D McSweeney,Ian Stewart,Zach Richardson et al.
Morgan D McSweeney et al.
The respiratory tract represents the key target for antiviral delivery in early interventions to prevent severe COVID-19. While neutralizing monoclonal antibodies (mAb) possess considerable efficacy, their current reliance on parenteral dos...
A hand-targeted auxiliary personal protective equipment for intervention of fomite transmission of viruses [0.03%]
一种用于阻断接触传播的辅助型手部个人防护装置
Justin Kok Soon Tan,Shang Wei Song,Jialiu Zeng et al.
Justin Kok Soon Tan et al.
In COVID-19, fomite transmission has been shown to be a major route for the spreading of the SARS-CoV-2 virus due to its ability to remain on surfaces for extended durations. Although glove wearing can mitigate the risk of viral transmissio...
An anatomically correct 3D-printed mouse phantom for magnetic particle imaging studies [0.03%]
一种用于磁性粒子成像研究的解剖学上正确的3D打印鼠标体模
Nicole S Sarna,Leyda Marrero-Morales,Ryan DeGroff et al.
Nicole S Sarna et al.
We report anatomically correct 3D-printed mouse phantoms that can be used to plan experiments and evaluate analysis protocols for magnetic particle imaging (MPI) studies. The 3D-printed phantoms were based on the Digimouse 3D whole body mou...
Near-infrared-induced drug release from antibody-drug double conjugates exerts a cytotoxic photo-bystander effect [0.03%]
近红外光诱导的抗体-药物双联供体释放对癌细胞产生细胞毒光辐射效应
Kazuomi Takahashi,Hirotoshi Yasui,Shunichi Taki et al.
Kazuomi Takahashi et al.
Ideal cancer treatments specifically target and eradicate tumor cells without affecting healthy cells. Therefore, antibody-based therapies that specifically target cancer antigens can be considered ideal cancer therapies. Antibodies linked ...
Zahra Pazhouhnia,Nima Beheshtizadeh,Mojdeh Salehi Namini et al.
Zahra Pazhouhnia et al.
Three-dimensional bioprinting, as a novel technique of fabricating engineered tissues, is positively correlated with the ultimate goal of regenerative medicine, which is the restoration, reconstruction, and repair of lost and/or damaged tis...
Bioprinted hASC-laden collagen/HA constructs with meringue-like macro/micropores [0.03%]
具有蛋白松饼状大/微孔的生物打印的hASC-载明胶/HA结构件
YoungWon Koo,Geun Hyung Kim
YoungWon Koo
Extrusion-based bioprinting is one of the most effective methods for fabricating cell-laden mesh structures. However, insufficient cellular activities within the printed cylindrical cell-matrix blocks, inducing low cell-to-cell interactions...
User-demand fast-curable ocular glues enforced by multilength tunable networks [0.03%]
用户需求的快速固结眼球胶水增强多长度可调网络
Hyeseon Lee,Ajeesh Chandrasekharan,Keum-Yong Seong et al.
Hyeseon Lee et al.
Achieving fast and secure wound closure without ocular foreign body sensation is highly desired in ophthalmologic surgery. Sutureless approaches using tissue adhesives are gaining popularity, but their practical use is limited by the diffic...
Integrated bioactive scaffold with aptamer-targeted stem cell recruitment and growth factor-induced pro-differentiation effects for anisotropic meniscal regeneration [0.03%]
一种集因子诱导促分化作用的各向异性半月板再生一体化生物活性支架及适配体靶向干细胞招募
Hao Li,Tianyuan Zhao,Fuyang Cao et al.
Hao Li et al.
Reconstruction of the knee meniscus remains a significant clinical challenge owing to its complex anisotropic tissue organization, complex functions, and limited healing capacity in the inner region. The development of in situ tissue-engine...
Design and validation of a tunable inertial microfluidic system for the efficient enrichment of circulating tumor cells in blood [0.03%]
一种用于高效捕获血液中循环肿瘤细胞的可调式惯性微流控系统的设计与验证
Alejandro Rodríguez-Pena,Estibaliz Armendariz,Alvaro Oyarbide et al.
Alejandro Rodríguez-Pena et al.
The analysis of circulating tumor cells (CTCs) in blood is a powerful noninvasive alternative to conventional tumor biopsy. Inertial-based separation is a promising high-throughput, marker-free sorting strategy for the enrichment and isolat...
Engineering hypertrophic cartilage grafts from lipoaspirate for critical-sized calvarial bone defect reconstruction: An adipose tissue-based developmental engineering approach [0.03%]
基于脂肪组织的发育工程方法构建肥大软骨移植物修复颅骨缺损的研究
Ru-Lin Huang,Rao Fu,Yuxin Yan et al.
Ru-Lin Huang et al.
Developmental engineering of living implants from different cell sources capable of stimulating bone regeneration by recapitulating endochondral ossification (ECO) is a promising strategy for large bone defect reconstruction. However, the c...